The impact of diabetes mellitus on tendon pathology: a review DOI Creative Commons
Jian Xu, Jinbo Wang,

Yuncong Ji

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 5, 2024

Diabetes is one of the most common metabolic diseases worldwide, leading to complications, mortality, and significant healthcare expenditures, which impose a substantial social financial burden globally. A diabetic environment can induce changes, negatively affecting tendon homeostasis, alterations in biomechanical properties histopathology. Numerous studies have investigated mechanisms through diabetes exerts pathological effects on tendons, including increased free radical production, oxidative stress, inflammatory responses, deposition advanced glycation end products (AGEs), microvascular changes. These changes damages structure, biomechanics, repair processes. The proliferation stem cells decreases, apoptosis increases, abnormal differentiation, along with expression myofibroblasts, ultimately lead insufficient repair, fibrosis, remodeling. Although researches unveiling tendinopathy, fibrosis or contracture, injury healing are growing, systematic understanding still lacking. Therefore, this review summarizes current research status provides comprehensive overview, offering theoretical guidance for future in-depth exploration impact tendons development treatments diabetes-related diseases.

Язык: Английский

Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis DOI
Paschalis Karakasis, Dimitrios Patoulias,

Nikolaos Fragakis

и другие.

Metabolism, Год журнала: 2024, Номер unknown, С. 156113 - 156113

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

8
Glucagon‐like peptide‐1 receptor agonist‐based agents and weight loss composition: Filling the gaps DOI
Robert L. Dubin, Steven B. Heymsfield, Éric Ravussin

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Abstract Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as first‐line treatments for T2D based on significant weight loss results. The composition using most diets consists <25% fat‐free mass (FFM) loss, with remainder from fat stores. Higher amounts (achieved metabolic bariatric surgery) result in greater reductions FFM. Our aim was to assess impact that GLP‐1RA‐based We analysed studies reported changes FFM following agents: exenatide, liraglutide, semaglutide, and dual incretin agonist tirzepatide. performed an analysis various interventions provide a reference expected evaluated dual‐energy X‐ray absorptiometry (DXA) measuring (a crude surrogate skeletal muscle). In evaluating percentage lost (%FFML) equal ΔFFM/total change. %FFML agents between 20% 40%. 28 clinical trials evaluated, proportion highly variable, but majority exceeding 25%. review limited small substudies use DXA, which does not measure muscle directly. Since contains variable amount (approximately 55%), this indirect may explain heterogeneity data. Assessing quantity quality advanced imaging (magnetic resonance imaging) functional testing will help fill gaps our current understanding.

Язык: Английский

Процитировано

5
Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application DOI Creative Commons
Qiqi Zhang,

Shiwan Hu,

Zishan Jin

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 6, 2024

Affected by aging, the elderly diabetes patients have many pathological characteristics different from young people, including more complications, vascular cognitive impairment, osteoporosis, and sarcopenia. This article will explore their pathogenesis mechanism of Traditional Chinese medicine (TCM) intervention, use method systematic review to evaluate clinical application TCM in diabetes.

Язык: Английский

Процитировано

4
Phase angle as an independent predictor of sarcopenia and glycemic control in older adults with type 2 diabetes: a cross-sectional observational study DOI
Go Owari,

Kenichi Kono,

Takahiro Nonaka

и другие.

Journal of Diabetes & Metabolic Disorders, Год журнала: 2025, Номер 24(1)

Опубликована: Март 15, 2025

Язык: Английский

Процитировано

0
Predictive Diagnostics of Risk Factors for the Development of Sarcopenia in Early Patients with Type 2 Diabetes DOI Creative Commons
Ю. Г. Самойлова, М.В. Матвеева, Ekaterina A. Khoroshunova

и другие.

The Russian Archives of Internal Medicine, Год журнала: 2024, Номер 14(1), С. 52 - 62

Опубликована: Фев. 13, 2024

Objective. Materials and methods: 82 patients with type 2 diabetes mellitus participated, which were divided into groups: probable sarcopenia comparison groups. Conducted: questionnaire surveys (Health Status Survey (SF-36)), Sarcopenia quality life assessment (SarQoL)), strength, assistance walking, getting up from a chair, climbing stairs falling — Strength, Assisted Climbing Falls (SARC-F)), of walking speed physical activity, carpal dynamometry, bioimpedancemetry, analysis laboratory parameters. Results: the difference between conducted questionnaires is statistically insignificant. According to bioimpedansometry, obesity 1st degree was recorded in lesions. In group presarcopenia, main decrease body composition parameters decreases. addition, group, rate intake reduced, decompensation carbohydrate lipid metabolism occurs. Differences considered significant at p < 0.05. Conclusion. Dynamometry bioimpedance can be used for primary screening diabetes. Maintaining indicators glycemia, correction dyslipidemia, compensation D hypocalcemia muscle mass mass.

Язык: Английский

Процитировано

3
Insulin resistance, type 2 diabetes mellitus and sarcopenia DOI Creative Commons

Д. П. Курмаев,

С. В. Булгакова, E. V. Treneva

и другие.

Experimental and Clinical Gastroenterology, Год журнала: 2024, Номер 2, С. 141 - 148

Опубликована: Март 26, 2024

Sarcopenia is a chronic age-associated disease, the prevalence of which increases with aging. The primary form associated aging, when no other causes have been identified, cause secondary sarcopenia may be various diseases, including type 2 diabetes mellitus (DM2). One common links in pathogenesis DM2 and insulin resistance. A combination obesity often observed. interrelation these pathological processes, etiology are presented this literature review.

Язык: Английский

Процитировано

3
Characterizing body composition modifying effects of a glucagon‐like peptide 1 receptor‐based agonist: A meta‐analysis DOI

Ruoyang Jiao,

Chu Lin, Xiaoling Cai

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Abstract Aim Diabetes is an independent risk factor for muscle mass loss, with possible mechanisms including impaired insulin signalling and chronic inflammation. The use of a glucagon‐like peptide 1 (GLP‐1) receptor‐based agonist could lead to weight reduction, which might result from the loss both fat skeletal muscle. However, body composition‐modifying effects GLP‐1 agonists have not been systematically characterized. Methods PubMed, EMBASE, Cochrane Center Register Controlled Trials Studies Clinicaltrial.gov were searched inception October 2023. Randomized controlled trials receptor or glucose‐dependent insulinotropic polypeptide/GLP‐1 dual agonist, reported changes composition, included. results computed as weighted mean differences (WMDs) 95% confidence intervals (CIs) in random‐effects model. Results In all, 19 randomized When compared controls, substantial reductions observed patients using treatment (WMD = −2.25 kg, CI −3.40 −1.10 kg), decrease areas subcutaneous −38.35 cm 2 , CI, −54.75 −21.95 ) visceral −14.61 −23.77 −5.44 ). Moreover, greater lean also users non‐users −1.02 −1.46 −0.57 while percentage comparable between non‐users. Conclusion Compared experienced mass, shaping terms mass. Although users,

Язык: Английский

Процитировано

3
Andaliman (Zanthoxylum acanthopodium DC.) fruit ethanolic extract exerts attenuative effect on hyperglycemia, sensory and motoric function’s disorders in alloxan-induced diabetic mice DOI Creative Commons
Putra Santoso,

Arin Saparima Simatupang,

Annisha Fajria

и другие.

Journal of Advanced Veterinary and Animal Research, Год журнала: 2024, Номер 0, С. 1 - 1

Опубликована: Янв. 1, 2024

Objective: Andaliman (Zanthoxylum acanthopodium) is a potent medicinal plant in Asia. This present study aimed to reveal the effectivity of fruit extract alleviating hyperglycemia, sensory and motoric balance disorders, histopathology cerebellum, tissue oxidative stress diabetic mice induced by alloxan. Materials Methods: Diabetes induction was performed intraperitoneally injecting alloxan monohydrate [200 mg/kg body weight (BW)]. Subsequently, were treated daily with an ethanolic (0, 150, 300, 450 BW per oral) for 28 days, followed measurements blood glucose, paw sensitivity, balance, malondialdehyde (MDA) levels. Moreover, phytochemical constituents elucidated liquid chromatography. Results: Higher doses could significantly attenuate elevation random fasting glucose (p < 0.05) improve sensitivity responses balances mice. degeneration cerebellar Purkinje cells suppress MDA levels while blunting brain 0.05). Phytochemical screening revealed 39 compounds belonging groups alkaloids (26 compounds), flavonoids (12 terpenoids (1 compound). Conclusion: The capable ameliorating neuropathy, motor cell also reducing peripheral system. Hence, promising candidate formulation as herbal remedy against detrimental outcomes diabetes mellitus.

Язык: Английский

Процитировано

1
Relationship of endogenous plasma concentrations of β-hydroxy β-methyl butyrate (HMB) with frailty in community dwelling older adults with type-2 diabetes mellitus DOI Creative Commons
Alejandro Álvarez‐Bustos,

José Antonio Carranza Carnicero,

Ricardo Rueda

и другие.

The journal of nutrition health & aging, Год журнала: 2024, Номер 28(6), С. 100229 - 100229

Опубликована: Апрель 9, 2024

Supplementation with β-hydroxy β-methyl butyrate (HMB) appears to be effective in preserving muscle older adults. However, the association between endogenously produced HMB frailty has not been studied people chronic disease. The purpose of this study is explore whether an exists endogenous levels and status adults type-2 diabetes mellitus (T2DM). Data were taken from Toledo Study Healthy Ageing, a community-dwelling aged (65 years+) cohort. Frailty was assessed at baseline 2.99 median years according Phenotype (FP) standardized our population Trait Scale 12 (FTS12). associations using three nested multivariate logistic regressions segmented by sex. Glucose, glucose interaction, age body composition used as covariables. 255 participants (mean 75.3 years, 52.94% men) included. showed inverse cross-sectional frailty, which modified when interaction term HMB*glucose included, remaining significant only for FTS12 [OR (95% CI): 0.436 (0.253, 0.751), p-value 0.003]. independent sex, maintained after adjusting covariates. there threshold points levels, above protective effect lost: 145.4 mg/dl adjusted gender whole sample 149.6 138.9 men women, respectively. Endogenous found associated incident frailty. Cross-sectional analysis revealed that inversely T2DM. This dependent on circulating fasted levels.

Язык: Английский

Процитировано

0
Changes in skeletal muscle in diabetes mellitus DOI Creative Commons

О. A. Shatskaya,

I. Z. Bondarenko, Svetlana V. Kushnarenko

и другие.

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 16, С. 148 - 153

Опубликована: Окт. 31, 2024

Diabetes mellitus is a group of metabolic (chemical processes) diseases characterized by chronic hyperglycemia. Globally, the number patients with diabetes follows an upward trend annual increase. As disease progresses, frequency micro and macrovascular complications gradually increases. In recent years, much attention has been paid to effect on skeletal muscle status. Structural functional abnormalities, disorders in muscles that develop ageing are also specifically attributed diabetes, but they manifest themselves at earlier age. Chronic hyperglycemia can accelerate process play crucial role development diabetic myopathy, which decreased mass, weakness atrophy, pain, impaired sensation even quadriplegia severe cases. A reduction rate protein synthesis rise its degradation pathophysiological sign atrophy. Research into molecular mechanisms myopathy will aid effective methods prevention treatment, however, achievement maintenance glycaemic targets plays critical ensuring health muscles, make it possible achieve disability improve patients’ quality life. Advanced glucometer models fitted range additional functions allow for structured self-monitoring blood glucose (SMBG), analysis obtained data timely correction therapy, active involvement management, significantly increase effectiveness management reduce risk diabetes.

Язык: Английский

Процитировано

0