Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in Polycystic Ovary Syndrome

Nutrients, Год журнала: 2024, Номер 16(17), С. 2961 - 2961

Опубликована: Сен. 3, 2024

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that impacts women of reproductive age. In addition to and psychological complications, with PCOS are also at higher risk developing metabolic diseases such as obesity, type 2 diabetes cardiovascular disease. While weight reduction can help manage these complications in overweight or obese women, many loss interventions have been ineffective due stigma its impact on PCOS. Therefore, exploring alternative dietary strategies which do not focus per se importance. this regard, omega-3 polyunsaturated fatty acids marine origin (n-3 PUFAs), known for their hypotriglyceridemic, cardioprotective anti-inflammatory effects, emerged potential therapy prevention reversal Several clinical trials showed n-3 PUFAs improve components review, we first summarize the available evidence different patterns improving complications. Next, alleviating Finally, explore mechanisms by disorders depth.

Язык: Английский

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The nonlinear association between body roundness index and infertility in married women

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 18, 2025

Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and but its implications for infertility risks diagnostic value are yet be fully determined. This study analyzed data from 1,305 married women aged 20-45 years, drawn the National Health Nutrition Examination Survey (NHANES). Logistic regression was utilized examine relationship between BRI infertility, incorporating univariate multivariate analyses, smooth curve fittings, subgroup analyses. Additionally, Receiver Operating Characteristic (ROC) analysis assessed predictive capability infertility. An increase in one unit correlated with 13% higher prevalence after adjusting covariates (OR = 1.13; 95% CI: 1.05, 1.21). Women exhibited greater odds compared reference group (OR: 2.20, 1.42, 3.42). Smooth fitting revealed positive, nonlinear relationship, an inflection point observed at 7.95. Subgroup analyses upheld robustness this association across varied demographic segments. ROC curves indicated significant potential younger women, whereas relevance diminished those over 35, akin other obesity markers. first rigorously affirm strong link increased among 20-45. To optimize fertility, maintaining healthy weight waist circumference recommended. integration into clinical practice could assist early intervention risk However, further research required identify effective markers 36-45.

Язык: Английский

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Adropin-Driven Browning: Targeting M2 Macrophages to Combat PCOS

International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114273 - 114273

Опубликована: Фев. 10, 2025

Язык: Английский

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Assessment of Serum Sestrin 2 Levels in Women With Polycystic Ovary Syndrome: A Single-Center Cross-Sectional Case-Control Study

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Objective Sestrin 2 (SESN2) is a stress-responsive protein implicated in metabolic regulation and oxidative stress. This study aims to assess serum SESN2 levels treatment-naive subjects with polycystic ovary syndrome (PCOS) compare them healthy controls. Methods The single-center cross-sectional case-control was conducted from February 2020 2021 at multispecialty center Bengaluru, India. included 37 newly diagnosed, drug-naive women PCOS 46 healthy, age-matched body mass index (BMI)-matched levels, along anthropometric parameters, were measured for both groups. Ethical approval obtained, all participants provided informed consent. Results involved 83 participants, divided into two groups: patients Significant differences observed between the groups terms of weight, hip circumference, levels. group had higher weight (P=0.024) larger circumference (P=0.037), while control exhibited waist-to-hip ratio (WHR) (P=0.007). Although no statistically significant difference found (BMI), showed elevated (P=0.024). Correlation analysis revealed negative correlation follicle-stimulating hormone (FSH) group. Receiver operating characteristic (ROC) curve determined cutoff 1.484 ng/mL, which demonstrated moderate sensitivity specificity distinguishing Conclusion significantly patients, correlations parameters. may play role hormonal disturbances PCOS, highlighting its potential as biomarker diagnosis management.

Язык: Английский

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Evaluation of body composition in body mass index matched PCOS and eumenorrheic non-PCOS college women

International Journal of Community Medicine and Public Health, Год журнала: 2025, Номер 12(4), С. 1682 - 1688

Опубликована: Март 28, 2025

Background: Poly cystic ovarian syndrome (PCOS) is a genetic, hormonal and metabolic disorder that affects the women of reproductive age. PCOS considered as one leading causes infertility in women. Body composition evaluation predictive factors risk assessment. The present study was undertaken with an objective to assess body distribution mass index (BMI) matched non-PCOS Methods: A comparative case control conducted BMI-matched, (n=55) college aged between 18-25 years. subjects were selected based on Rotterdam criteria. Prior study, ethical clearance certificate obtained. Based BMI cohort, healthy BMI. including anthropometry analysed through bioelectrical impedance standard protocols. Results: Non-PCOS groups showed non-significant differences most their anthropometric parameters except weight, neck size, height. However, total per cent fat visceral levels found be significantly high p value <0.001** p=0.005 respectively. Additionally, skeletal muscle index, mass, protein content significant low at 99% CI. Conclusions: Visceral deposition percent generally associated disturbance changes it highly prominent compared eumenorrheic controls.

Язык: Английский

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Is Measuring BMI and Waist Circumference as Good in Assessing Insulin Resistance as Using Bioelectrical Impedance to Measure Total Body Fat and Visceral Fat?

Diabetology, Год журнала: 2025, Номер 6(4), С. 32 - 32

Опубликована: Апрель 17, 2025

Background: Insulin resistance (IR) is a metabolic disorder linked to type 2 diabetes and cardiovascular diseases. Visceral fat better predictor of IR than BMI waist circumference due its inflammatory impact. Methods such as DEXA bioimpedance (BIA) estimate body fat, while scales METS-IR, SPISE, TyG assess risk. This study analyzes the utility visceral measured by BIA compared other indicators. Methods: A cross-sectional was conducted on 8590 workers in Balearic Islands, analyzing anthropometric, clinical, analytical variables. Body were bioimpedance, insulin assessed using TyG. ROC curves used evaluate predictive value BMI, WC, fat. Results: The areas under curve (AUCs) highest for high particularly women (>0.97), indicating excellent performance. showed lowest AUC, especially men. AUC all scales. Youden’s indices with good capacity, low values, limiting predicting resistance. Conclusions: Measuring superior or WC estimating

Язык: Английский

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Neck circumference as a metabolic health marker among women with polycystic ovary syndrome (PCOS): a systematic review and meta-analysis

International Journal of Obesity, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Язык: Английский

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Association of FTO protein with hyperandrogenism metabolic disturbances in women with polycystic ovary syndrome

Endocrine Regulations, Год журнала: 2025, Номер 59(1), С. 33 - 41

Опубликована: Янв. 1, 2025

Abstract Objective. Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies in women characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance affecting 5–20% reproductive-aged worldwide. Recent studies have emphasized role fat mass obesity-associated (FTO) gene development PCOS, specifically rs9939609 A/T polymorphism, which linked to an increased risk PCOS. The study aimed investigate levels FTO protein its association with luteinizing hormone (LH), follicle-stimulating (FSH) anthropometric parameters patients PCOS compared healthy controls. Materials. A total 298 women, comprising 149 controls, enrolled study. Anthropometric (body index, BMI; waist circumference, WC; hip HC; waist-to-hip ratio, WHR), hormonal assays (LH, FSH, LH/FSH ratio) were performed. measured ELISA kit their these was analyzed. receiver operator characteristic (ROC) curve analysis performed evaluate discriminatory power distinguishing cases value p<0.05 considered statistically significant. Results. significantly elevated BMI, WC, HC, WHR (p=<0.05). mean BMI showed a positive correlation both WC (r=0.367, p<0.001) HC (r=0.395, p<0.001). strongly correlated (r=0.780, (r=0.465, LH FSH (r=0.543, p<.001), (r=0.553, p<.001). (r=0.364, p<0.001), (r=0.166, Additionally, negative (r=–0.190, p<0.05), (r=–0.277, (r=–0.408 observed. higher Significant correlations also found between or parameters. AUC for 0.624 (p=0.550), indicating moderate power, but lacking statistical significance. Conclusion. that are correlating (increased LH, decreased FSH). This highlights potential involvement metabolic disturbances characteristics biomarker character condition.

Язык: Английский

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Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8098 - 8098

Опубликована: Июль 25, 2024

In recent years, the incidence of metabolic syndrome (MS) has increased due to lifestyle-related factors in developed countries. MS represents a group conditions that increase risk diabetes, cardiovascular diseases, and other severe health problems. Low-grade chronic inflammation is now considered one key aspects could be defined as new factor. Indeed, an visceral adipose tissue, typical obesity, contributes development inflammatory state, which, turn, induces production several proinflammatory cytokines responsible for insulin resistance. Psoriasis relapsing skin disease characterized by release pro-inflammatory cytokines, which can contribute different pathological within spectrum MS. A link between disorders emerged from evidence indicating weight loss obtained through healthy diets exercise was able improve clinical course therapeutic response patients with obesity or overweight even prevent its occurrence. factor this balance gut microbiota; it extremely dynamic system, makes manipulation diet possible via probiotic, prebiotic, symbiotic compounds. Given this, microbiota additional target metabolism conditions.

Язык: Английский

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Association of body roundness index with female infertility: 2013–2018 NHANES

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Окт. 30, 2024

This study aims to understand the association between body roundness index (BRI) and female infertility prevalence. Infertility is a public health concern with significant implications for individuals' well-being rights.

Язык: Английский

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