The Relationship Between Lycopene and Metabolic Diseases

Nutrients, Год журнала: 2024, Номер 16(21), С. 3708 - 3708

Опубликована: Окт. 30, 2024

Metabolic syndrome, obesity, and type 2 diabetes are closely related. They characterized by chronic inflammation oxidative stress. Obesity is the most important risk factor for metabolic syndrome diabetes. insulin resistance elevated blood glucose levels, among other conditions. These disorders contribute to development of diabetes, which can exacerbate problems.

Язык: Английский

---

Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 27, 2025

ABSTRACT Lycopene (LYC) is an extremely powerful antioxidant with the potential to treat a range of diseases and inhibit ferroptosis. This research aims elucidate how LYC impacts polycystic ovarian syndrome (PCOS) action mechanisms. A PCOS rat model was constructed by injecting DHEA. Different doses were injected intraperitoneally in rats, estrous cycle recorded. The histopathological damage ovary rats observed HE staining, testosterone (T), estradiol (E2), luteinizing hormone (LH) follicle stimulating (FSH) levels examined ELISA kits. Transmission electron microscopy, prussian blue biochemical kits determine Immunohistochemistry Western blot assess ferroptosis‐related AMPK/Nrf2 pathway‐related proteins explore whether affects ferroptosis through this pathway. had significantly higher body weights, weights indices, disorganized cycles, which dose‐dependently ameliorated LYC. In addition, restored normal secretion T, E2, LH, FSH. attenuates iron deposition tissues, reduces ROS levels, inhibits Notably, activated pathway, AMPK inhibitor intervention attenuated therapeutic effect suggesting that acts disruption, ameliorates pathological impairments, modulating

Язык: Английский

---

Ecuadorian roots flours: bioactive compounds and processing properties

Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101740 - 101740

Опубликована: Фев. 1, 2025

Язык: Английский

---

Lycopene: A potent antioxidant to alleviate kidney disease

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114363 - 114363

Опубликована: Март 1, 2025

Язык: Английский

---

Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 14, 2025

Introduction Although previous researches have suggested that certain dietary nutrients, such as carotenoids, an effect on depression, epidemiological evidence the relationship between lycopene and depression remains limited. This study aimed to investigate association intake risk in American adults. Methods Data from 18,664 participants National Health Nutrition Examination Survey (NHANES, 2007–2016) were analyzed, with defined by a nine-item Patient Questionnaire (PHQ-9) score ≥ 10. Dietary was estimated mean of two 24-h recalls. Binary logistic regression restricted cubic spline (RCS) models employed assess relationship. Results Depression prevalence 8.98%, adjusted analyses indicated higher significantly associated reduced compared lowest quartile (ORs for second, third, fourth quartiles: 0.851 [95% CI, 0.737–0.982], 0.829 0.716–0.960], 0.807 0.695–0.938], respectively). Additionally, U-shaped observed, reduction ranging 0 10,072 μg/d ( P -non-linear = 0.017). Discussion may confer protective against

Язык: Английский

---

Lycopene Supplemented Mediterranean Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) in Mice and Changes Intestinal Microbiome

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Май 5, 2025

Abstract This study aimed to determine the effects of Mediterranean diet (MD) and lycopene on development EAE inflammatory markers. In 43-day study, 72 female C57BL/6 mice were randomly divided into eight groups according whether they or naive (control) mice, fed a Western MD, received lycopene. During ad libitum, given 10 mg/kg/day per mouse every other day for 28 days in oral gavage. The scored EAE, sacrificed their spleen, lymph nodes, spinal cords removed. We observed slightly delayed onset MD-Lyc group compared others, clinical scores also lower than groups. T-cell counts spleen nodes significantly production IFN-γ IL-22 was higher IL-17 A cytokine produced addition, highest myelination score seen group. had unique microbiome profile with remaining summary, MD administration positively impacted myelination. However, more comprehensive studies at vitro vivo levels are needed reveal effect this intervention cell numbers CNS. Graphical

Язык: Английский

---

Developing carotenoids-enhanced tomato fruit with multi-transgene stacking strategies

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 210, С. 108575 - 108575

Опубликована: Март 28, 2024

Язык: Английский

---

Investigation of cyclodextrin as potential carrier for lycopene

Arhiv za farmaciju, Год журнала: 2024, Номер 74(3), С. 178 - 205

Опубликована: Янв. 1, 2024

Lycopene is a carotenoid with high antioxidant activity. Numerous studies show its positive effects in the prevention and amelioration of many diseases. However, due to lack water solubility, use very limited. Developing formulation lycopene favorable therapeutic parameters will allow for more effective this ingredient. The aim study was therefore supercritical phase extraction obtain lycopene-containing preparations, complexes extract cyclodextrins improve solubility increase potential. Lycopene-containing extracts were obtained by ultrasound-assisted acetone extraction. combined g-cyclodextrin, b-cyclodextrin 2-hydroxypropyl-b-cyclodextrin. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) X-ray diffraction (XRD) analyses performed systems extracts. A paddle apparatus used evaluate vitro dissolution, samples collected analysed HPLC. activity assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical method. results that dissolution into an acidic environment enhance potential compound. We conclude development containing combination cyclodextrin wider

Язык: Английский

---

Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells

Nutrients, Год журнала: 2024, Номер 16(10), С. 1443 - 1443

Опубликована: Май 10, 2024

Recent interest in preventing the development of osteoporosis has focused on regulation redox homeostasis. However, action lycopene (LYC), a strong natural antioxidant compound, osteoporotic bone loss remains largely unknown. Here, we show that oral administration LYC to OVX rats for 12 weeks reduced body weight gain, improved lipid metabolism, and preserved quality. In addition, treatment inhibited ROS overgeneration serum marrow rats, BMSCs upon H2O2 stimulation, leading inhibiting adipogenesis promoting osteogenesis during remodeling. At molecular level, quality via an increase expressions FoxO1 Runx2 decrease PPARγ C/EBPα BMSCs. Collectively, these findings suggest attenuates through FoxO1/PPARγ pathway driven by oxidative stress, presenting novel strategy management.

Язык: Английский

---

Molecular mechanisms and potential targets of lycopene for alleviating renal ischemia-reperfusion injury revealed by network pharmacology and animal experiments

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113421 - 113421

Опубликована: Окт. 22, 2024

Язык: Английский

---