Recent
interest
in
preventing
the
development
of
osteoporosis
has
focused
on
regulation
redox
homeostasis.
However,
action
lycopene
(LYC),
a
strong
natural
antioxidant
com-pound,
osteoporotic
bone
loss
remains
largely
unknown.
Here,
we
show
that
administra-tion
LYC
to
OVX
rats
reduces
body
weight
gain,
improves
lipid
metabolism
and
preserves
quality.
In
addition,
treatment
inhibits
ROS
overgeneration
serum
marrow
rats,
BMSCs
upon
H2O2
stimulation,
leading
inhibiting
adipogenesis
pro-moting
osteogenesis
during
remodeling.
Mechanically,
may
improve
quality
via
an
increase
expressions
FoxO1
Runx2,
decrease
PPARγ
C/EBPα
BMSCs.
Collectively,
these
findings
suggest
attenuates
through
promoting
regula-tion
FoxO1/PPARγ
pathway
driven
by
oxidative
stress,
presenting
novel
strategy
for
os-teoporosis
management.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: April 14, 2025
Introduction
Although
previous
researches
have
suggested
that
certain
dietary
nutrients,
such
as
carotenoids,
an
effect
on
depression,
epidemiological
evidence
the
relationship
between
lycopene
and
depression
remains
limited.
This
study
aimed
to
investigate
association
intake
risk
in
American
adults.
Methods
Data
from
18,664
participants
National
Health
Nutrition
Examination
Survey
(NHANES,
2007–2016)
were
analyzed,
with
defined
by
a
nine-item
Patient
Questionnaire
(PHQ-9)
score
≥
10.
Dietary
was
estimated
mean
of
two
24-h
recalls.
Binary
logistic
regression
restricted
cubic
spline
(RCS)
models
employed
assess
relationship.
Results
Depression
prevalence
8.98%,
adjusted
analyses
indicated
higher
significantly
associated
reduced
compared
lowest
quartile
(ORs
for
second,
third,
fourth
quartiles:
0.851
[95%
CI,
0.737–0.982],
0.829
0.716–0.960],
0.807
0.695–0.938],
respectively).
Additionally,
U-shaped
observed,
reduction
ranging
0
10,072
μg/d
(
P
-non-linear
=
0.017).
Discussion
may
confer
protective
against
Journal of Neuroimmune Pharmacology,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: May 5, 2025
Abstract
This
study
aimed
to
determine
the
effects
of
Mediterranean
diet
(MD)
and
lycopene
on
development
EAE
inflammatory
markers.
In
43-day
study,
72
female
C57BL/6
mice
were
randomly
divided
into
eight
groups
according
whether
they
or
naive
(control)
mice,
fed
a
Western
MD,
received
lycopene.
During
ad
libitum,
given
10
mg/kg/day
per
mouse
every
other
day
for
28
days
in
oral
gavage.
The
scored
EAE,
sacrificed
their
spleen,
lymph
nodes,
spinal
cords
removed.
We
observed
slightly
delayed
onset
MD-Lyc
group
compared
others,
clinical
scores
also
lower
than
groups.
T-cell
counts
spleen
nodes
significantly
production
IFN-γ
IL-22
was
higher
IL-17
A
cytokine
produced
addition,
highest
myelination
score
seen
group.
had
unique
microbiome
profile
with
remaining
summary,
MD
administration
positively
impacted
myelination.
However,
more
comprehensive
studies
at
vitro
vivo
levels
are
needed
reveal
effect
this
intervention
cell
numbers
CNS.
Graphical
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 25, 2024
The
ability
of
Deinococcus
bacteria
to
survive
in
harsh
environments,
such
as
high
radiation,
extreme
temperature,
and
dryness,
is
mainly
attributed
the
generation
unique
pigments,
especially
carotenoids.
Although
limited
number
natural
pigments
produced
by
these
restricts
their
industrial
potential,
metabolic
engineering
synthetic
biology
can
significantly
increase
pigment
yield
expand
application
prospects.
In
this
study,
we
review
properties,
biosynthetic
pathways,
functions
key
enzymes
genes
related
explore
strategies
for
improving
production
through
gene
editing
optimization
culture
conditions.
Additionally,
studies
have
highlighted
role
antioxidant
activity
radiation
resistance,
particularly
emphasizing
critical
deinoxanthin
D.
radiodurans
.
future,
bacterial
will
broad
prospects
food
industry,
drug
production,
space
exploration,
where
they
serve
indicators
antioxidants
protect
astronauts’
health
during
long-term
flights.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3708 - 3708
Published: Oct. 30, 2024
Metabolic
syndrome,
obesity,
and
type
2
diabetes
are
closely
related.
They
characterized
by
chronic
inflammation
oxidative
stress.
Obesity
is
the
most
important
risk
factor
for
metabolic
syndrome
diabetes.
insulin
resistance
elevated
blood
glucose
levels,
among
other
conditions.
These
disorders
contribute
to
development
of
diabetes,
which
can
exacerbate
problems.
Arhiv za farmaciju,
Journal Year:
2024,
Volume and Issue:
74(3), P. 178 - 205
Published: Jan. 1, 2024
Lycopene
is
a
carotenoid
with
high
antioxidant
activity.
Numerous
studies
show
its
positive
effects
in
the
prevention
and
amelioration
of
many
diseases.
However,
due
to
lack
water
solubility,
use
very
limited.
Developing
formulation
lycopene
favorable
therapeutic
parameters
will
allow
for
more
effective
this
ingredient.
The
aim
study
was
therefore
supercritical
phase
extraction
obtain
lycopene-containing
preparations,
complexes
extract
cyclodextrins
improve
solubility
increase
potential.
Lycopene-containing
extracts
were
obtained
by
ultrasound-assisted
acetone
extraction.
combined
g-cyclodextrin,
b-cyclodextrin
2-hydroxypropyl-b-cyclodextrin.
Attenuated
total
reflectance
Fourier
transform
infrared
spectroscopy
(ATR-FTIR)
X-ray
diffraction
(XRD)
analyses
performed
systems
extracts.
A
paddle
apparatus
used
evaluate
vitro
dissolution,
samples
collected
analysed
HPLC.
activity
assessed
using
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radical
method.
results
that
dissolution
into
an
acidic
environment
enhance
potential
compound.
We
conclude
development
containing
combination
cyclodextrin
wider
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1443 - 1443
Published: May 10, 2024
Recent
interest
in
preventing
the
development
of
osteoporosis
has
focused
on
regulation
redox
homeostasis.
However,
action
lycopene
(LYC),
a
strong
natural
antioxidant
compound,
osteoporotic
bone
loss
remains
largely
unknown.
Here,
we
show
that
oral
administration
LYC
to
OVX
rats
for
12
weeks
reduced
body
weight
gain,
improved
lipid
metabolism,
and
preserved
quality.
In
addition,
treatment
inhibited
ROS
overgeneration
serum
marrow
rats,
BMSCs
upon
H2O2
stimulation,
leading
inhibiting
adipogenesis
promoting
osteogenesis
during
remodeling.
At
molecular
level,
quality
via
an
increase
expressions
FoxO1
Runx2
decrease
PPARγ
C/EBPα
BMSCs.
Collectively,
these
findings
suggest
attenuates
through
FoxO1/PPARγ
pathway
driven
by
oxidative
stress,
presenting
novel
strategy
management.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(7), P. 445 - 445
Published: June 21, 2024
Imidacloprid
(IMI)
is
a
commonly
used
new-generation
pesticide
that
has
numerous
harmful
effects
on
non-targeted
organisms,
including
animals.
This
study
analysed
both
the
adverse
pancreas
following
oral
consumption
of
imidacloprid
neonicotinoids
(45
mg/kg
daily
for
30
days)
and
potential
protective
lycopene
(LYC)
administration
(10
mg/kg/day
with
IMI
exposure
in
male
Sprague-Dawley
rats.
The
apoptotic,
pyroptotic,
inflammatory,
oxidative
stress,
endoplasmic
reticulum
stress
biomarkers
were
evaluated,
along
histopathological
alterations.
Upon
administration,
noticeable
changes
observed
pancreatic
histopathology.
Additionally,
elevated
oxidative/endoplasmic
reticulum-associated
biomarkers,
apoptotic
also
administration.
LYC
effectively
reversed
these
alterations
by
reducing
markers
(e.g.,
MDA)
enhancing
antioxidant
enzymes
(SOD,
CAT).
It
downregulated
ER
(IRE1α,
XBP1,
CHOP),
decreased
pro-inflammatory
cytokines
(TNF-α,
IL-1β),
suppressed
pyroptotic
(NLRP3,
caspase-1)
(Bax,
cleaved
caspase-3).
improved
ultrastructure
brought
toxicity.
