Amelioration of Serum Aβ Levels and Cognitive Impairment in APPPS1 Transgenic Mice Following Symbiotic Administration
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2381 - 2381
Опубликована: Июль 23, 2024
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
process
responsible
for
almost
70%
of
all
cases
dementia.
The
clinical
signs
consist
in
progressive
and
irreversible
loss
memory,
cognitive,
behavioral
functions.
main
histopathological
hallmark
the
accumulation
amyloid-ß
(Aß)
peptide
fibrils
brain.
To
date,
origin
Aß
has
not
been
determined.
Recent
studies
have
shown
that
gut
microbiota
produces
Aß,
dysbiotic
states
identified
AD
patients
animal
models
AD.
Starting
from
hypothesis
maintaining
or
restoring
microbiota’s
eubiosis
essential
to
control
Aß’s
production
deposition
brain,
we
used
mixture
probiotics
prebiotics
(symbiotic)
treat
APPPS1
male
female
mice,
an
model
AD,
2
8
months
age
evaluated
their
cognitive
performances,
mucus
secretion,
Aβ
serum
concentration,
composition.
results
showed
treatment
was
able
prevent
memory
deficits,
reduced
increased
blood
levels,
imbalance
found
mice.
present
study
demonstrates
gut–brain
axis
plays
critical
role
genesis
impairment,
modulation
can
ameliorate
AD’s
symptomatology.
Язык: Английский
Psychobiotics and the gut-brain axis: advances in metabolite quantification and their implications for mental health
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 20
Опубликована: Фев. 5, 2025
Psychobiotics
are
live
microorganisms
that,
when
administered
in
adequate
amounts,
confer
mental
health
benefits
to
the
host.
Several
clinical
studies
have
demonstrated
significant
from
psychobiotic
administration,
making
them
an
emerging
topic
food
science.
Certain
strains
of
Lactobacillus,
Bifidobacterium,
Streptococcus,
Escherichia,
and
Enterococcus
species
known
for
their
ability
modulate
gut-brain
axis
provide
benefits.
Proposed
action
mechanisms
include
production
neuroactive
compounds
or
precursors,
which
may
cross
blood-brain
barrier,
transported
by
extracellular
vesicles.
However,
there
is
a
lack
vivo
evidence
directly
confirming
these
mechanisms,
although
indirect
recent
suggest
potential
pathways
further
investigation.
To
advance
our
understanding,
it
crucial
study
within
host,
with
accurate
quantification
and/or
precursors
being
key
such
studies.
Current
methods,
however,
face
challenges,
as
low
sensitivity
detecting
trace
metabolites
limited
specificity
due
interference
other
compounds,
impacting
reliability
measurements.
This
review
discusses
field
psychobiotics,
compound
estimation
techniques,
perspectives
improvement
quantifying
Язык: Английский
Prophylactic effects of supplementation of a combination of Lactobacillus lactis WHH2078 and saffron on depressive‐like behaviors in mice exposed to chronic stress
Journal of Food Science,
Год журнала:
2024,
Номер
89(9), С. 5912 - 5927
Опубликована: Авг. 10, 2024
Abstract
Depression
is
one
of
the
most
common
psychiatric
conditions
worldwide,
with
an
annual
escalation
in
prevalence.
The
serotonin
(5‐Hydroxytryptamine
[5‐HT])
metabolism
through
gut–brain
axis
has
been
revealed
to
be
related
development
depression.
Our
previous
study
demonstrated
that
Lactococcus
lactis
WHH2078
alleviated
depression
mice
by
shaping
gut
microbiome
composition
and
5‐HT
metabolism.
However,
little
research
explored
synergistic
effects
probiotics
natural
mental
health‐improving
products.
In
this
study,
three
products
(saffron,
l
‐theanine,
phosphatidylserine),
either
individually
or
combination,
were
orally
administrated
for
4
weeks
chronic
restraint
stress
(CRS)‐induced
mice,
their
depressive
behaviors,
hippocampal
5‐HT,
serum
corticosterone
assessed.
Saffron
improvement
depressive‐like
behaviors
via
multiple
behavioral
tests
reversed
declined
concentration
increased
corticosterone.
Following
initial
screening,
saffron
was
chosen
combined
WHH2078,
referred
as
WHHMOOD™.
Furthermore,
WHHMOOD
evaluated
behaviors.
reduced
immobility
time
forced
swimming
test
tail
suspension
test,
spent
central
area
open
field
level.
Besides,
improved
CRS‐induced
microbial
dysbiosis
reversing
diversity
abundances
Ligilactobacillus,
Candidatus
Arthromitus
,
Erysipelatoclostridium
.
Compared
treatment
significantly
travel
distance
level
mice.
conclusion,
exhibited
prophylactic
on
CRS
which
may
act
a
promising
agent
improving
symptoms
Язык: Английский
Ascorbic acid improves cognitive levels in middle-aged mice and increases CD8 + T cells by binding Myh9 protein and enriches gut microbiota Akkermansia muciniphila
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 15, 2024
Abstract
Background:
Immunosenescence
accelerates
systemic
aging
and
influences
cognitive
function,
with
antioxidants
potentially
mitigating
these
effects.
The
significance
of
ascorbic
acid
(vitamin
C)
as
a
crucial
antioxidant
in
anti-aging
cognition,
well
the
potential
impact
gut
microbiome
on
this
process,
has
yet
to
be
investigated.
Results:
In
study,
we
systematically
assessed
immunosenescence
function
middle-aged
aged
mice.
findings
demonstrated
notable
rise
peripheral
blood
lymphocytes,
decline
myeloid
immune
cells,
enhanced
performance.
In
vitro
studies
indicated
that
facilitated
differentiation
mouse
hematopoietic
stem
cells
(HSCs)
spleen
monocytes
into
CD8
+
T
its
efficacy
primarily
mediated
by
interaction
protein
Myh9
protein.
A
positive
correlation
was
observed
between
function.
Furthermore,
distinction
exists
oral
intravenous
administration
enhancing
attributable
modulation
Akkermansia
muciniphila.
Intravenous
delivery
notably
enhances
A.
muciniphila
abundance
significantly
performance
elderly
mice,
whereas
supplementation
increases
cell
count
demographic
only
when
co-administered
Conclusion:
This
study
can
mitigate
and,
conjunction
muciniphila,
improves
These
offer
mechanistic
rationale
for
utilizing
nutritional
interventions
enhance
underscores
importance
selecting
optimal
route
achieving
intended
Язык: Английский
Lactococcus strains with psychobiotic properties improve cognitive and mood alterations in aged mice
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 1, 2024
Aging
often
accompanies
cognitive
and
mood
disturbances.
Emerging
evidence
indicates
that
specific
probiotics
mitigate
dysfunctions.
Strains
within
Язык: Английский