Psychobiotics and the gut-brain axis: advances in metabolite quantification and their implications for mental health

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 5, 2025

Psychobiotics are live microorganisms that, when administered in adequate amounts, confer mental health benefits to the host. Several clinical studies have demonstrated significant from psychobiotic administration, making them an emerging topic food science. Certain strains of Lactobacillus, Bifidobacterium, Streptococcus, Escherichia, and Enterococcus species known for their ability modulate gut-brain axis provide benefits. Proposed action mechanisms include production neuroactive compounds or precursors, which may cross blood-brain barrier, transported by extracellular vesicles. However, there is a lack vivo evidence directly confirming these mechanisms, although indirect recent suggest potential pathways further investigation. To advance our understanding, it crucial study within host, with accurate quantification and/or precursors being key such studies. Current methods, however, face challenges, as low sensitivity detecting trace metabolites limited specificity due interference other compounds, impacting reliability measurements. This review discusses field psychobiotics, compound estimation techniques, perspectives improvement quantifying

Language: Английский

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Amelioration of Serum Aβ Levels and Cognitive Impairment in APPPS1 Transgenic Mice Following Symbiotic Administration

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2381 - 2381

Published: July 23, 2024

Alzheimer’s disease (AD) is a neurodegenerative process responsible for almost 70% of all cases dementia. The clinical signs consist in progressive and irreversible loss memory, cognitive, behavioral functions. main histopathological hallmark the accumulation amyloid-ß (Aß) peptide fibrils brain. To date, origin Aß has not been determined. Recent studies have shown that gut microbiota produces Aß, dysbiotic states identified AD patients animal models AD. Starting from hypothesis maintaining or restoring microbiota’s eubiosis essential to control Aß’s production deposition brain, we used mixture probiotics prebiotics (symbiotic) treat APPPS1 male female mice, an model AD, 2 8 months age evaluated their cognitive performances, mucus secretion, Aβ serum concentration, composition. results showed treatment was able prevent memory deficits, reduced increased blood levels, imbalance found mice. present study demonstrates gut–brain axis plays critical role genesis impairment, modulation can ameliorate AD’s symptomatology.

Language: Английский

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Prophylactic effects of supplementation of a combination of Lactobacillus lactis WHH2078 and saffron on depressive‐like behaviors in mice exposed to chronic stress

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(9), P. 5912 - 5927

Published: Aug. 10, 2024

Abstract Depression is one of the most common psychiatric conditions worldwide, with an annual escalation in prevalence. The serotonin (5‐Hydroxytryptamine [5‐HT]) metabolism through gut–brain axis has been revealed to be related development depression. Our previous study demonstrated that Lactococcus lactis WHH2078 alleviated depression mice by shaping gut microbiome composition and 5‐HT metabolism. However, little research explored synergistic effects probiotics natural mental health‐improving products. In this study, three products (saffron, l ‐theanine, phosphatidylserine), either individually or combination, were orally administrated for 4 weeks chronic restraint stress (CRS)‐induced mice, their depressive behaviors, hippocampal 5‐HT, serum corticosterone assessed. Saffron improvement depressive‐like behaviors via multiple behavioral tests reversed declined concentration increased corticosterone. Following initial screening, saffron was chosen combined WHH2078, referred as WHHMOOD™. Furthermore, WHHMOOD evaluated behaviors. reduced immobility time forced swimming test tail suspension test, spent central area open field level. Besides, improved CRS‐induced microbial dysbiosis reversing diversity abundances Ligilactobacillus, Candidatus Arthromitus , Erysipelatoclostridium . Compared treatment significantly travel distance level mice. conclusion, exhibited prophylactic on CRS which may act a promising agent improving symptoms

Language: Английский

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Ascorbic acid improves cognitive levels in middle-aged mice and increases CD8 + T cells by binding Myh9 protein and enriches gut microbiota Akkermansia muciniphila

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Background: Immunosenescence accelerates systemic aging and influences cognitive function, with antioxidants potentially mitigating these effects. The significance of ascorbic acid (vitamin C) as a crucial antioxidant in anti-aging cognition, well the potential impact gut microbiome on this process, has yet to be investigated. Results: In study, we systematically assessed immunosenescence function middle-aged aged mice. findings demonstrated notable rise peripheral blood lymphocytes, decline myeloid immune cells, enhanced performance. In vitro studies indicated that facilitated differentiation mouse hematopoietic stem cells (HSCs) spleen monocytes into CD8⁺ T its efficacy primarily mediated by interaction protein Myh9 protein. A positive correlation was observed between function. Furthermore, distinction exists oral intravenous administration enhancing attributable modulation Akkermansia muciniphila. Intravenous delivery notably enhances A. muciniphila abundance significantly performance elderly mice, whereas supplementation increases cell count demographic only when co-administered Conclusion: This study can mitigate and, conjunction muciniphila, improves These offer mechanistic rationale for utilizing nutritional interventions enhance underscores importance selecting optimal route achieving intended

Language: Английский

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Lactococcus strains with psychobiotic properties improve cognitive and mood alterations in aged mice

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 1, 2024

Aging often accompanies cognitive and mood disturbances. Emerging evidence indicates that specific probiotics mitigate dysfunctions. Strains within

Language: Английский

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