Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 3 - 35
Опубликована: Ноя. 1, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер 203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Язык: Английский
Процитировано
15
Antibiotics, Год журнала: 2024, Номер 13(7), С. 603 - 603
Опубликована: Июнь 28, 2024
Nowadays, infectious diseases of bacterial and viral origins represent a serious medical problem worldwide. In fact, the development antibiotic resistance is responsible for emergence strains that are refractory even to new classes antibiotics. Furthermore, recent COVID-19 pandemic suggests viruses can emerge spread all over world. The increase in depends on multiple factors, including malnutrition, massive migration population from developing industrialized areas, alteration human microbiota. Alternative treatments conventional antibiotics antiviral drugs have intensively been explored. this regard, plants marine organisms an immense source products, such as polyphenols, alkaloids, lanthipeptides, terpenoids, which possess antibacterial activities. Their main mechanisms action involve modifications cell membranes, with formation pores, release cellular content, inhibition adherence host cells, well efflux pump. Natural antivirals interfere replication spreading, protecting enhanced production interferon. Of note, these not free side effects, their administration humans needs more research terms safety. Preclinical natural compounds confirms effects against bacteria viruses, but there still only few clinical trials. Therefore, full exploitation intensive studies next steps be pursued area medicine.
Язык: Английский
Процитировано
5
Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have wide range employment, from food production to medical usages. Among beneficial applications polyphenols, their antiviral activity is gaining importance due increased prevalence drug‐resistant viruses such as herpes hepatitis B viruses. In present review, we provide an overview most promising or commonly used polyphenols mechanisms action focusing on effects enveloped clinical (double‐stranded linear partially double‐stranded circular DNA viruses, negative sense single‐stranded RNA with nonsegmented segmented genomes, positive viruses). The work emphasizes relevance in particular epigallocatechin‐3‐gallate resveratrol, alternative supportive antivirals. could interfere virtually all steps viral infection, adsorption release particles. against especially relevant given risk widespread outbreaks associated remarked recent COVID‐19 pandemic.
Язык: Английский
Процитировано
0
Molecular Biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 29, 2025
Язык: Английский
Процитировано
0
Biology, Год журнала: 2023, Номер 12(11), С. 1437 - 1437
Опубликована: Ноя. 16, 2023
Polyphenols have gained increasing attention for their therapeutic potential, particularly in conditions like cancer, due to established antioxidant and anti-inflammatory properties. Recent research highlights ability bind transition metals, such as copper. This is noteworthy given the key role of copper both initiation progression cancer. Copper can modulate activity kinases required epithelial-mesenchymal (EMT), a process fundamental tumor cell dissemination. We previously demonstrated copper-binding capacity oleuropein, secoiridoid found Olea europaea. In present study, we investigated effect hydroxytyrosol, primary oleuropein metabolite, on metastatic potential three triple-negative breast cancer lines (MDA-MB-231, MDA-MB-468, SUM159). that hydroxytyrosol modulated intracellular levels, influencing epithelial mesenchymal markers, by downregulating copper-dependent AKT phosphorylation, member EMT signaling cascade, through Western blot, RT-qPCR, immunofluorescence. Indeed, optical spectra, EPR, silico approaches, formed complex with copper, acting chelating agent, thus regulating its homeostasis affecting cascades. While our results bring light copper-chelating properties capable countering progression, they also provide further confirmation promoting aggressiveness cells.
Язык: Английский
Процитировано
8
Aquaculture, Год журнала: 2024, Номер 589, С. 740967 - 740967
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
1
NFS Journal, Год журнала: 2024, Номер 37, С. 100194 - 100194
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
1
Nutrients, Год журнала: 2023, Номер 15(22), С. 4719 - 4719
Опубликована: Ноя. 8, 2023
Although the COVID-19 pandemic appears to be diminishing, emergence of SARS-CoV-2 variants represents a threat humans due their inherent transmissibility, immunological evasion, virulence, and invulnerability existing therapies. The affected more than 500 million people caused over 6 deaths. Vaccines are essential, but in circumstances which vaccination is not accessible or individuals with compromised immune systems, drugs can provide additional protection. Targeting host signaling pathways recommended genomic stability resistance barriers. Moreover, targeting factors allows us develop compounds that effective against different viral as well newly emerging virus strains. In recent years, globe has experienced climate change, may contribute spread infectious diseases through variety factors. Warmer temperatures changing precipitation patterns increase geographic range disease-carrying vectors, increasing risk spreading new areas. Climate change also affect vector behavior, leading longer breeding season sites for disease vectors. disrupt ecosystems, bringing closer wildlife transmits zoonotic diseases. All above accelerate epidemics. Plant-derived products, have been used traditional medicine treating pathological conditions, offer structurally novel therapeutic compounds, including those anti-viral activity. addition, plant-derived bioactive substances might serve ideal basis developing sustainable/efficient/cost-effective alternatives. Interest herbal antiviral products increased. More 50% approved originate from sources. diverse structures molecules candidates drug development. Combining these therapies conventional could improve patient outcomes. Epigenetics modifications genome gene expression without altering DNA sequences. Host cells use epigenetic regulation mechanism silence incoming molecules, while viruses recruit cellular epitranscriptomic (covalent RNAs) modifiers translational efficiency transcript transcripts enhance replication. manipulate cells' machinery ensure productive infections. Environmental factors, such natural influence modifications. this review, we explore potential broad-spectrum activity, reviewing modulation processes effects on RNA viruses, addressing future research objectives rapidly field.
Язык: Английский
Процитировано
2
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 3 - 35
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0