Black Barley Grain and Its Processing By-Product as a Potential Raw Material for Functional Food

Food and Bioprocess Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Flavonoids and the gut microbiome: a powerful duo for brain health

Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Дек. 4, 2024

Flavonoids, a class of polyphenolic compounds, are widely distributed in plant-based foods and have been recognized for their potential to promote overall health well-being. Flavonoids fruits vegetables offer various beneficial effects such as anti-aging, anticancer, anti-inflammatory properties. extensively studied neuroprotective properties, which attributed ability cross the blood-brain barrier interact with neural cells. Factors like gut microbiota composition, age, genetics, diet can impact how well flavonoids absorbed gut. The enhance absorption through enzymatic processes, making composition key factor influenced by diet. modulate prebiotic antimicrobial effects, affecting production microbial metabolites short-chain fatty acids (SCFAs) butyrate, play role brain function health. microbiome also modulates immune system, is critical preventing neuroinflammation. Additionally, benefit mental psychological influencing signaling pathways cells increasing tyrosine tryptophan, precursors neurotransmitters serotonin, dopamine, norepinephrine, adrenaline, gamma-aminobutyric acid (GABA). flavonoid-gut axis complex multifaceted relationship that has significant implications neurological This review will explore genetic environmental factors flavonoid positive on network.

Язык: Английский

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Nutrition and Huntington’s Disease– A Review of Current Practice and Theory

Current Nutrition Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Янв. 16, 2025

Nutition has long been of importance in the care Huntington's disease (HD). The purpose this review is to summarize recent research relevant HD nutrition, and describe some emerging theoretical approaches area. Clinical studies have identified swallowing problems fear choking as major impediments maintaining nutritional status with HD. Tube feeding associated co-morbidities, provides limited benefits. Non-human models utilized study diets supplements. Application findings from these humans not shown be comparable benefit. While factors non-human promising results, trials found little efficacy for or complexity human metabolic pathways may require a more sophisticated omics approach identify beneficial interventions.

Язык: Английский

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Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends?

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Association of whole blood multi-micronutrients with mild cognitive impairment in Chinese older adults: a matched case–control study

European Journal of Nutrition, Год журнала: 2025, Номер 64(3)

Опубликована: Март 6, 2025

Adequate micronutrients play a crucial role in cognitive health. Identifying relevant and constructing risk prediction models can guide the prevention of mild impairment (MCI) older adults. This study aimed to assess associations MCI with whole blood micronutrient levels develop nomogram for personalized In matched case-control study, 100 patients controls by age, sex education from Baodi District, Tianjin, China were recruited. was determined modified version Petersen criteria. Whole 9 vitamins 5 minerals measured using dried spot technique. Weighted quantile sum regression employed identify most significant associated function. Receiver operating characteristic (ROC) curves constructed, predicting developed. High (vitamin A, vitamin B2, B6, B9) (magnesium, selenium) significantly lower prevalence, which B9 selenium ranked as contributors The ROC B2 (area under curve = 0.855) have superior diagnostic accuracy compared individual assessments (p < 0.05). Based on these findings, developed two predict risk. based be effectively used detect early preventive strategies

Язык: Английский

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Risk Factors of Optic Neuropathy in Ethambutol Users: Interaction with Isoniazid and Other Associated Conditions of Toxic Optic Neuropathy

Toxics, Год журнала: 2024, Номер 12(8), С. 549 - 549

Опубликована: Июль 30, 2024

(1) Background: To investigate the risk factors associated with optic neuropathy (ON) and validate hypothesis that concomitant isoniazid use other causes of toxic ON affect development in ethambutol users. (2) Methods: This cohort study identified users who initiated therapy between January 2015 December 2021 had no prior to therapy. incidence up 31 2022 was evaluated. The were grouped on basis presence ON. Demographic clinical characteristics investigated for factor analyses Odds ratios (ORs) calculated using multivariate logistic regression analyses. (3) Results: Among 204,598 users, 5277 (2.6%) patients developed over period. Patients included a higher percentage women mean age than without In analyses, visual impairment sex, age, cumulative dose, extrapulmonary indications use, systemic conditions such as diabetes, hypertension, hyperlipidemia, kidney disease, liver disease. Malnutrition or nutritional disorders significantly increased (OR = 1.27, 95% confidence interval [CI] 1.19-1.34), whereas decreased 0.78, CI 0.72-0.86). (4) Conclusion: An diseases deficiency identified, these should be carefully monitored minimize vision-threatening

Язык: Английский

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Beneficial Effects of Manilkara zapota-Derived Bioactive Compounds in the Epigenetic Program of Neurodevelopment

Nutrients, Год журнала: 2024, Номер 16(14), С. 2225 - 2225

Опубликована: Июль 11, 2024

Gestational diet has a long-dated effect not only on the disease risk in offspring but also occurrence of future neurological diseases. During ontogeny, changes epigenetic state that shape morphological and functional differentiation several brain areas can affect embryonic fetal development. Many mechanisms such as DNA methylation hydroxymethylation, histone modifications, chromatin remodeling, non-coding RNAs control gene expression, both course neurodevelopment adult cognitive functions. Epigenetic alterations have been linked to neuro-evolutionary disorders with intellectual disability, plasticity, memory synaptic learning disorders. processes act specifically, affecting different regions based accessibility cell-specific states, facilitating establishment lost balance. Recent insights underscored interplay between enzymes active during development presence bioactive compounds, vitamins polyphenols. The fruit

Язык: Английский

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Vitamin D and Cognitive Performance in Older Adults: A Cross-Sectional and Mendelian Randomization Study

ALPHA PSYCHIATRY, Год журнала: 2024, Номер 25(3), С. 323 - 328

Опубликована: Авг. 2, 2024

Cognitive decline is a prevalent health problem in older adults, and effective treatments remain to be produced. Serum vitamin D, commonly used biochemical marker, widely recognized as an indicator of various diseases. Existing research has not fully elucidated the relationship between D cognitive function. The aim this study investigate real function identify indicators that have strong predictive effect on decline. At first, we dataset genome-wide association studies studying performance conduct Mendelian randomization analysis. Subsequently, employed linear regression smooth curve fitting methods assess using National Health Nutrition Examination Survey data. Finally, investigated other features utilizing machine learning model. We found 1-unit increase associated with 6.51% reduction (P < .001) risk correlation nonlinear, inflection point at 79.9 nmol/L (left: β = 0.043, P .001; right: -0.007, .420). In learning, top 5 predictors are weight, height, age, body mass index. There causal performance. could optimal dose for supplementation elderly. Further consideration factors interventions necessary.

Язык: Английский

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Diet and Nutrients in Rare Neurological Disorders: Biological, Biochemical, and Pathophysiological Evidence

Nutrients, Год журнала: 2024, Номер 16(18), С. 3114 - 3114

Опубликована: Сен. 15, 2024

Background/Objectives: Rare diseases are a wide and heterogeneous group of multisystem life-threatening or chronically debilitating clinical conditions with reduced life expectancy relevant mortality rate in childhood. Some these disorders have typical neurological symptoms, presenting from birth to adulthood. Dietary patterns nutritional compounds play key roles the onset progression disorders, impact alimentary needs must be enlightened especially rare diseases. This work aims collect vitro, vivo, evidence on effects diet nutrient intake some including genetic diseases, brain tumors. Herein, those aspects critically linked genetic, biological, biochemical, pathophysiological hallmarks each disorder. Methods: By searching major web-based databases (PubMed, Web Science Core Collection, DynaMed, Clinicaltrials.gov), we try sum up improve our understanding emerging role nutrition as both first-line therapy risk factors Results: In line increasing number consensus opinions suggesting that nutrients should receive same attention pharmacological treatments, results this pointed out standard dietary recommendation specific disease is often limited by heterogeneity occurrent mutations variability manifestation. Conclusions: conclusion, hope knowledge gaps identified here may inspire further research for better evaluation molecular mechanisms long-term effects.

Язык: Английский

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Causal effects of dietary antioxidant vitamin intake and oxidative stress on the risk of pre-eclampsia and gestational hypertension: a mendelian randomization study.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 2, 2024

Background: Oxidative stress plays a critical role in the progression of pre-eclampsia and gestational hypertension. The body's own antioxidant system (including GST, CAT, GPX, SOD) dietary intake antioxidants such as vitamin A (retinol), carotene, C, E have been proven to counter oxidative stress-related damage. However, no comprehensive studies explored correlation between these factors risk [5] Methods: Instrumental variables (IVs) for four mentioned were obtained from largest GWAS dataset based on UK Biobank data, followed by two-sample Mendelian randomization study. IVs, F-statistics, Cochran’s Q tests, sensitivity analysis used examine causal relationship intake, stress, statistics quantify heterogeneity instrumental variable estimates. [7] Results: IVW method indicated an approximate 5.0% decreased hypertension per standard deviation (SD) increase SOD (OR = 0.95; 95% CI 0.90-1.00, p 0.048). For other biomarkers vitamins, significant effects observed (Retinol: 0.79 (0.56–1.11), 0.18; Carotene: 1.03 (0.78–1.36), 0.81; Vitamin C: (0.57–1.10), 0.16; E: 1.16 (0.86–1.56), 0.32; GST: 1.00 (0.96–1.05), 0.93; CAT: 0.88; GPX: 1.01 (0.96–1.06), 0.74). Similar results found pre-eclampsia. [9] Conclusion: This study suggests that is closely related supplements A, E, carotenoids did not show improvement or [11]

Язык: Английский

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