The Ongoing Impact of COVID-19 on Pediatric Obesity

Pediatric Reports, Год журнала: 2024, Номер 16(1), С. 135 - 150

Опубликована: Фев. 2, 2024

In the developed world, pediatric obesity (PO) has been a major health concern since last century, and this condition may lead to detrimental life-long physical mental comorbidities. Currently, its prevalence increased in low- middle-income countries many high-income countries. Thus, provision of effective tailored care for children their families become vital. The social consequences COVID-19 pandemic are known everywhere, among these, it argued that had impact on PO. Overall, growth PO over decade enhanced by pandemic. During pandemic, children, adolescents young adults gained weight as population dealt with sedentary lifestyles changes food habits. review, we want highlight

Язык: Английский

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Gut microbiota and inflammatory factor characteristics in major depressive disorder patients with anorexia

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Май 2, 2024

Abstract Background This study aimed to explore the gut microbiota and inflammatory factor characteristics in major depressive disorder (MDD) patients with anorexia analyze correlation between factors, anorexia, HAMD scores. Methods 46 MDD healthy controls (HC) were included study. The divided into two groups according whether they had anorexia:20 without (MDA0 group) 26 (MDA1 group). We used Hamilton Depression Scale-24 (HAMD-24) evaluate depression status of all participants 16 S ribosomal RNA (16 rRNA)sequencing composition microbiota. Inflammatory factors peripheral blood such as C-reactive protein (CRP) detected using enzyme-linked immunosorbent assay (ELISA). Spearman’s analysis was scores, anorexia. Results 1). CRP significantly higher MDA0, MDA1, than HC. 2). An α-diversity shows: Simpson Pielou indices HC group are MDA1 ( P < 0.05). 3). β-diversity shows differences microbial communities group. 4). A showed that Blautia positively correlated level, whereas Faecalibacterium, Bacteroides, Roseburia, Parabacteroides negatively level. 5). receiver operating characteristic (ROC) curve drawn differential bacterial genera or biomarkers identify accompanied its area under (AUC) 0.85. ROC diagnose AUC 0.97. Conclusion suggested a distinct compared individuals, level CRP. more abundant CRP, might have influenced through

Язык: Английский

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Endocrine gastroenterological aspects of metabolic dysfunction

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 9, С. 36 - 43

Опубликована: Март 6, 2025

This review article examines the endocrine gastroenterological aspects of metabolic dysfunction, which is a complex pathological condition that affects metabolism and accompanied by disturbances in functioning system. The introduction focuses on key hormones such as insulin leptin their roles regulating digestive processes. consequences secretion these hormones, including development type 2 diabetes mellitus obesity, are discussed. offers comprehensive analysis relationship between disruption problems irritable bowel syndrome, highlighting importance further research to understand mechanisms underlying diseases. results this can serve basis for new approaches diagnosis treatment disorders, well formation strategies prevention associated

Язык: Английский

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Virtual reality versus 2D biofeedback for children and adolescents with stress related disorders: a randomized controlled trial

Virtual Reality, Год журнала: 2025, Номер 29(2)

Опубликована: Март 8, 2025

Язык: Английский

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Different action of glucocorticoid receptor in adipose tissue remodelling to modulate energy homeostasis by chronic restraint stress

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Март 27, 2025

Abstract Background Chronic stress in daily life is a well-known trigger for various health issues. Despite advancements obesity research, the mechanisms governing lipid metabolism adipose tissue during cachexia remain poorly understood. Methods A chronic restraint (CRS) model was used to induce significant physiological and psychological mice. Mice were subjected 6 h of 50 mL plastic tubes seven consecutive days. fasting control group included comparison. Post-stress assessments behavioural tests, glucose insulin tolerance tests indirect calorimetry. Blood samples collected mRNA protein analyses. Results CRS induced changes mice, including depression-like behaviours, weight loss reduced sensitivity. Notably, caused extensive remodelling. White (WAT) underwent ‘browning’ accompanied by an increase expression thermogenic proteins. This counteracted stress-induced ‘whitening’ brown (BAT), which exhibited impaired thermogenesis functionality, thereby maintaining energy balance systematically. The glucocorticoid receptor (GR) plays crucial role regulation these changes. GR levels inversely correlated BAT WAT, but aligned with patterns proteins across tissues. These findings suggest that under metabolic stress, mediates tissue-specific responses tissues, driving functional phenotypic transitions WAT maintain homeostasis. Conclusions study provides novel insights into contrasting phenotypes emaciation highlights critical GRs remodelling its potential as therapeutic target. Addressing GR-mediated tissues may help alleviate dysfunction promote browning, enhancing resistance.

Язык: Английский

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Obesity-Related Complications Including Dysglycemia Based on 1-h Post-Load Plasma Glucose in Children and Adolescents Screened before and after COVID-19 Pandemic

Nutrients, Год журнала: 2024, Номер 16(15), С. 2568 - 2568

Опубликована: Авг. 5, 2024

Childhood obesity, with its metabolic complications, is a problem of public health. The International Diabetes Federation (IDF) has recommended glucose levels 1 h post oral load (1h-PG) > 155–209 mg/dL as diagnostic for intermediate hyperglycemia (IH), while >209 type 2 diabetes (T2D). aim the study was to assess occurrence prediabetes, IH, and T2D in children adolescents simple obesity according criteria American Association (ADA) IDF, effect COVID-19 pandemic on these disorders. Analysis included 263 screened either prepandemic (PRE—113 cases) or post-pandemic period (POST—150 cases). All underwent OGTT measurements insulin every 0.5 h, lipid profile, other tests; indices if resistance (IR): HOMA, QUICKI, Matsuda index, AUC (glu/ins) were calculated. incidence T2D, IH higher POST respect PRE, significant differences IR, except HOMA. Significant observed assessed parameters metabolism among groups normal tolerance (NGT), some similarities between (based 1h-PG) prediabetes. Increased frequency dysglycemia after pandemic. Metabolic profile patients at 1h-PG “intermediate” NGT

Язык: Английский

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Research trends between childhood obesity and gut microbiota: a bibliometric analysis (2002–2023)

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Сен. 27, 2024

Background In recent years, the prevalence of childhood obesity has escalated alarmingly, posing significant threats to physical and mental well-being children, with an elevated likelihood persisting into adulthood. Notably, investigations have uncovered a profound association between intestinal microbiota, crucial component internal milieu, obesity. Disturbances in microbiota their by-products are now understood be profoundly intertwined evolutionary pathway Bibliometric analysis offers deep understanding current research landscape, so we apply it review emerging trends patterns gut microbiota. Materials methods We conducted rigorous extensive search Web Science (WoS) Core Collection database, spanning years from 1900 2023, analyze scholarly articles pertaining Utilizing VOSviewer, CiteSpace, R package “bibliometrix,” online bibliometric platform ( https://bibliometric.com/ ), delved intricate details hotspots, academic collaborations, within this domain. Results The exhaustive encompassed globe, uncovering cumulative total 1,384 pertinent studies originating 429 nations. results were compelling, revealing influence exerted by United States China specific field research. Furthermore, was observed that volume works is steadily growing year on year. hot topics include “abuse,” “maltreatment,” “adverse experiences,” “students,” “food addiction”. Conclusion This comprehensive meticulous exploration evolving agendas over past two decades. It strives equip researchers thorough key nations, institutions, journals, potential collaborators these specialized fields. Additionally, sheds light frontiers strategic avenues for further exploration, thus serving as invaluable resource scholars delving deeper intricacies microbiome.

Язык: Английский

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Body Weight and Food/Eating-Related Behaviors During the COVID-19 Pandemic or Other Traumatic or Stressful Life Events

Nutrients, Год журнала: 2024, Номер 16(21), С. 3701 - 3701

Опубликована: Окт. 30, 2024

The COVID-19 pandemic has been a pivotal event, reshaping many aspects of daily life and public health across the globe [...].

Язык: Английский

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Associations between Changes in Body Weight Status and High Blood Pressure among Lithuanian Children and Adolescents during the COVID-19 Pandemic: A Retrospective Cohort Study

Nutrients, Год журнала: 2024, Номер 16(19), С. 3256 - 3256

Опубликована: Сен. 26, 2024

(1) Background: High blood pressure (HBP), overweight, and obesity are common, growing public health problems worldwide. The aim of this study was to evaluate associations between changes in body weight status HBP among Lithuanian children adolescents during the COVID-19 pandemic. (2) Methods: In study, we analysed data on anthropometric measurements 2430 aged 8–18 years, who participated both baseline conducted before pandemic (from November 2019 March 2020) follow-up 2021 April 2022). Multivariate logistic regression analysis used estimate categories HBP. (3) Results: At baseline, 17.1% subjects had 5.9% obesity, 5.6% abdominal 23.7% HBP, whereas at follow-up, these percentages increased 20.1%, 8.2%, 6.8%, 27.4%, respectively. Compared schoolchildren maintained normal from period, newly developed overweight/obesity those remained with persistent odds adjusted ratios (aORs) 1.95 (p < 0.001) 2.58 0.001), transitioned weight, were slightly increased, an aOR 1.14 = 0.598), but change not statistically significant > 0.05). (4) Conclusions: This observed increase prevalence also suggested that especially overweight/obesity, associated higher

Язык: Английский

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The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12409 - 12409

Опубликована: Ноя. 19, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted need multi-target DMT approach in PD that recognizes various risk factors and their intricate interplay contributing to PD-related neurodegeneration. Widespread factors, such as emotional stress metabolic have increasingly become focal points of exploration. Our review aims summarize interactions between selected key players metabolism, insulin, potential mechanisms underlying neurodegeneration PD.

Язык: Английский

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