Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review
Applied Biosciences,
Год журнала:
2024,
Номер
3(3), С. 392 - 425
Опубликована: Сен. 22, 2024
The
olive
tree
is
currently
cultivated
worldwide,
with
higher
incidence
in
Mediterranean
Basin.
Its
climate
highly
favorable
to
the
synthesis
of
phenolic
compounds,
stored
leaves;
their
consumption
has
been
linked
a
lower
cancer
and
cardiovascular
disorders
for
which
research
interest
upon
this
feature
increased
last
decade.
This
study
aimed
(i)
review
evidence
about
importance
leaf
extract
(OLE)
on
human
health
physiological
effect
its
major
compounds;
(ii)
update
state
art
studies
conducted
technological
usage
extract;
(iii)
report
potential
uses
OLE
pharmaceuticals,
food
production,
cosmetics;
(iv)
prospect
future
clinical
applications
from
diverse
cultivars,
especially
metabolic
inflammatory
conditions
such
as
polycystic
ovary
syndrome
(PCOS).
Overall,
cultivars
richer
TPC,
including
TFC,
αT,
omega-3
omega-9,
present
main
target
supplementation
alone
or
conjunction
vitaminic
due
nutraceutical
value
disorders,
chronic
diseases,
anti-aging
treatments,
whereas
less
water
content
might
be
useful
substrates
preservation.
With
regard
prospects,
it
would
great
clarify
specific
mechanisms
underlying
beneficial
effects
neuro-immune
design
safer
healthier
nature-based
medicine
wide
array
costly
prevalent
metabolic-related
syndromes,
namely,
PCOS.
Язык: Английский
Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1307 - 1307
Опубликована: Апрель 9, 2025
Hericium
erinaceus,
commonly
known
as
lion’s
mane
mushroom,
has
gained
increasing
scientific
interest
due
to
its
rich
composition
of
bioactive
compounds
and
diverse
health-promoting
properties.
This
narrative
review
provides
a
comprehensive
overview
the
nutritional
therapeutic
potential
H.
with
particular
focus
on
anti-inflammatory,
antioxidant,
antimicrobial
activities.
A
structured
literature
search
was
performed
using
databases
such
PubMed,
Scopus,
Science
Direct,
Web
Science,
Google
Scholar.
Studies
published
in
last
two
decades
focusing
erinaceus’
were
included.
The
chemical
erinaceus
includes
polysaccharides,
terpenoids
(hericenones
erinacines),
phenolic
compounds,
which
exhibit
potent
antioxidant
effects
by
scavenging
reactive
oxygen
species
(ROS)
inducing
endogenous
enzymes.
Additionally,
shows
promising
activity
against
bacterial
fungal
pathogens,
applications
combating
antibiotic-resistant
infections.
mushroom’s
capacity
stimulate
nerve
growth
factor
(NGF)
synthesis
highlighted
preventing
managing
neurodegenerative
diseases,
Alzheimer’s
Parkinson’s.
Advances
biotechnological
methods,
including
optimized
cultivation
techniques
novel
extraction
may
further
enhance
bioavailability
pharmacological
erinaceus.
Despite
findings,
clinical
validation
remains
limited.
Future
research
should
prioritize
large-scale
trials,
standardization
elucidation
pharmacokinetics
facilitate
integration
into
evidence-based
medicine.
functional
food,
nutraceutical,
adjunct
agent
highlights
need
for
interdisciplinary
collaboration
between
researchers,
clinicians,
regulatory
bodies.
Язык: Английский
The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Язык: Английский
Mechanistic Insights of Neuroprotective Efficacy of Verapamil-Loaded Carbon Quantum Dots against LPS-Induced Neurotoxicity in Rats
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7790 - 7790
Опубликована: Июль 16, 2024
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
that
badly
impacts
patients
and
their
caregivers.
AD
characterized
by
deposition
of
amyloid
beta
(Aβ)
phosphorylated
tau
protein
(pTau)
in
the
brain
with
underlying
neuroinflammation.
We
aimed
to
develop
neuroprotective
paradigm
loading
verapamil
(VRH)
into
hyaluronic
acid-modified
carbon
quantum
dots
(CQDs)
comparing
its
effectiveness
free
form
an
AD-like
model
rats
induced
lipopolysaccharide
(LPS).
The
experimental
were
divided
seven
groups:
control,
LPS,
CQDs,
early
VRH
(FVRH),
late
FVRH,
(VCQDs),
VCQDs.
Characterizations
VCQDs,
behavioral
performance
rats,
histopathological
immunohistochemical
changes,
some
hallmarks,
oxidative
stress
biomarkers,
neuro-affecting
genes,
DNA
fragmentation
determined.
was
successfully
loaded
which
confirmed
measured
parameters.
showed
enhancement
cognitive
functions,
disruption
architecture
brain,
decreased
Aβ
pTau,
increased
antioxidant
capacity,
modifiable
expression
decline
fragmentation.
therapy
superior
drug.
Moreover,
intervention
better
than
late,
confirming
implication
detected
molecular
targets
development
AD.
multifaceted
mechanisms
combating
LPS-induced
neurotoxicity
through
anti-inflammatory
properties,
thereby
mitigating
hallmarks
Additionally,
synthesized
nanosystem
approach
exhibited
neuroprotection
owing
advantages
offered
CQDs.
However,
finding
new
actionable
biomarkers
decisive
importance
improve
outcomes
for
Язык: Английский
Exploring the molecular mechanisms of curcumin in modulating memory impairment in neurodegenerative disorders
Molecular Biology Reports,
Год журнала:
2024,
Номер
52(1)
Опубликована: Дек. 9, 2024
Язык: Английский
Carob (Ceratonia siliqua) leaves: A comprehensive analysis of bioactive profile and health-promoting potential of an untapped resource
Food Chemistry,
Год журнала:
2024,
Номер
468, С. 142392 - 142392
Опубликована: Дек. 9, 2024
Carob
is
a
resilient
plant
with
ecological
and
nutritional
significance.
A
comprehensive
study
of
Ceratonia
siliqua
leaves
(CSL)
was
conducted
to
explore
its
chemical
composition
health-promoting
potential,
aiming
at
improving
the
carob-crop
sustainability
through
valorization
this
untapped
co-product.
UHPLC-DAD-HRMS/MS
quali-quantitative
profiling
CSL
revealed
high
levels
n-galloylated
glucoses
(129-196
mg
g
Язык: Английский
The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13338 - 13338
Опубликована: Дек. 12, 2024
Resveratrol,
a
naturally
occurring
polyphenolic
compound
found
in
various
plants,
has
been
extensively
studied
for
its
broad
spectrum
of
beneficial
biological
effects.
These
encompass
potent
antioxidant
properties,
anti-inflammatory
activities,
anti-aging
capabilities,
cardioprotective
functions,
and
neuroprotective
potential.
The
diverse
actions
resveratrol
extend
beyond
these
well-established
properties.
It
also
exerts
significant
impact
on
metabolic
processes
bioavailability,
critically,
it
demonstrates
the
ability
to
effectively
traverse
blood–brain
barrier.
This
capacity
penetrate
central
nervous
system
renders
promising
therapeutic
agent
management
malignancies,
as
shown
inhibit
tumor
cell
proliferation,
induce
apoptosis,
modulate
key
signaling
cascades,
such
PI3K/Akt,
JAK/STAT,
NF-kB.
multifaceted
nature
resveratrol’s
effects,
including
influence
physiological
processes,
underscores
potential
valuable
option
treatment
tumors.
Язык: Английский
Enzyme ChE, cholinergic therapy and molecular docking: Significant considerations and future perspectives
International Journal of Immunopathology and Pharmacology,
Год журнала:
2024,
Номер
38
Опубликована: Янв. 1, 2024
Enzyme
Che
plays
an
essential
role
in
cholinergic
and
non-cholinergic
functions.
It
is
present
the
fertilized/unfertilized
eggs
sperm
of
different
species.
Inclusion
criteria
for
data
collection
from
electronic
databases
NCBI
Google
Scholar
are
enzyme
AChE/BChE,
therapy,
genomic
organization
gene
transcription,
structure,
biogenesis,
transport,
processing
localization,
molecular
signaling
biological
function,
polymorphism
influencing
factors.
acts
as
a
receptor
during
hematopoiesis,
protein
adhesion,
amyloid
fiber
formation,
neurite
outgrowth,
bone
development,
maturation,
explaining
activity
out
synaptic
neurotransmission.
Polymorphism
genes
correlates
to
various
diseases
diverse
drug
responses.
In
particular,
change
accompanies
cancer,
neurodegenerative,
cardiovascular
disease.
Literature
knowledge
indicates
importance
inhibitors
that
influence
biochemical
pathways
disease
treatment,
organization,
processing,
localization
enzyme.
changes
indicate
possibility
efficient
new
inhibitor
target
mechanisms
research
areas.
Язык: Английский
Targeting protein aggregation using a cocoa-bean shell extract to reduce α-synuclein toxicity in models of Parkinson’s disease
Current Research in Food Science,
Год журнала:
2024,
Номер
9, С. 100888 - 100888
Опубликована: Янв. 1, 2024
Neurodegenerative
diseases
are
among
the
major
challenges
in
modern
medicine,
due
to
progressive
aging
of
world
population.
Among
these,
Parkinson's
disease
(PD)
affects
10
million
people
worldwide
and
is
associated
with
aggregation
presynaptic
protein
α-synuclein
(α-syn).
Here
we
use
two
different
PD
models,
yeast
cells
neuroblastoma
overexpressing
α-syn,
investigate
protective
effect
an
extract
from
cocoa
shell,
which
a
by-product
roasting
process
beans.
The
LC-ESI-qTOF-MS
NMR
analyses
allow
identification
amino
acids
(including
essential
ones),
organic
acids,
lactate
glycerol,
confirming
also
presence
methylxanthines,
namely
caffeine
theobromine.
present
study
demonstrates
that
supplementation
bean
shell
(CBSE)
strongly
improves
longevity
expressing
reducing
level
reactive
oxygen
species,
activating
autophagy
intracellular
aggresomes.
These
anti-aggregation
properties
confirmed
cells,
where
CBSE
treatment
leads
activation
AMPK
kinase
significant
reduction
toxic
α-syn
oligomers.
Results
obtained
by
surface
plasmon
resonance
(SPR)
assay
highlights
binds
concentration-dependent
manner,
supporting
its
inhibitory
role
on
amyloid
α-syn.
findings
suggest
form
nutraceuticals
may
represent
promising
way
prevent
neurodegenerative
aggregation.
Язык: Английский
Neurotropic and immunomodulatory properties of a novel bioflavonoid composition
Reviews on Clinical Pharmacology and Drug Therapy,
Год журнала:
2024,
Номер
22(4), С. 361 - 376
Опубликована: Дек. 15, 2024
BACKGROUND:
Flavonoids,
a
class
of
plant
polyphenols,
exhibit
wide
range
biological
(neuro-
and
immunotropic,
antioxidant,
anti-inflammatory,
epigenome-modulating)
properties
involved
in
the
mechanisms
management
various
pathological
processes,
including
nervous
system
diseases.
Alcoholism
is
pervasive
social,
medical,
economic
issue
modern
society.
Prolonged
exposure
to
ethanol
has
direct
mediated
toxic
effect
on
human
body
through
its
metabolites
negatively
affecting
immune
systems
that
play
major
role
adaptation.
The
ability
bioflavonoids
manage
disorders
chronic
diseases
with
neuroimmune
pathogenesis
by
interacting
specific
cell
surface
receptors
can
provide
therapeutic
benefits
alcoholism.
AIM:
To
assess
neurotropic
immunomodulatory
novel
curcumin-based
bioflavonoid
composition
during
prolonged
consumption.
MATERIALS
AND
METHODS:
content
was
measured
aqueous-organic
extracts
using
high-performance
liquid
chromatography
(HPLC).
Chronically
alcoholized
male
(CBA×C57Bl/6)F1
mice
who
received
10%
solution
as
sole
source
fluid
six
months
were
administered
30
days.
Subsequent
studies
assessed
alcohol
motivation
consumption
free
choice
water,
well
behavioral
parameters
open
field
test,
cytokine
brain
structures
(prefrontal
cortex,
hypothalamus,
hippocampus,
striatum)
enzyme
immunoassay.
intensity
cellular
humoral
response
determined
severity
delayed-type
hypersensitivity
relative
number
splenic
antibody-forming
cells,
respectively.
RESULTS:
quantitative
consisting
curcumin,
piperine,
soybean
isoflavonoids,
epigallocatechin-3-gallate,
triterpene
saponins,
β-carotene.
Taking
this
context
shown
have
positive
expressed
correcting
alcoholism-related
phenotype
(reduced
motivation,
stimulation
locomotor
exploratory
activity),
accompanied
decreased
levels
certain
proinflammatory
cytokines
(most
pronounced
hippocampus).
Stimulation
also
demonstrated
after
course
treatment
described
composition.
CONCLUSIONS:
data
support
use
an
additional
agent
Язык: Английский