Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1307 - 1307

Published: April 9, 2025

Hericium erinaceus, commonly known as lion’s mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview the nutritional therapeutic potential H. with particular focus on anti-inflammatory, antioxidant, antimicrobial activities. A structured literature search was performed using databases such PubMed, Scopus, Science Direct, Web Science, Google Scholar. Studies published in last two decades focusing erinaceus’ were included. The chemical erinaceus includes polysaccharides, terpenoids (hericenones erinacines), phenolic compounds, which exhibit potent antioxidant effects by scavenging reactive oxygen species (ROS) inducing endogenous enzymes. Additionally, shows promising activity against bacterial fungal pathogens, applications combating antibiotic-resistant infections. mushroom’s capacity stimulate nerve growth factor (NGF) synthesis highlighted preventing managing neurodegenerative diseases, Alzheimer’s Parkinson’s. Advances biotechnological methods, including optimized cultivation techniques novel extraction may further enhance bioavailability pharmacological erinaceus. Despite findings, clinical validation remains limited. Future research should prioritize large-scale trials, standardization elucidation pharmacokinetics facilitate integration into evidence-based medicine. functional food, nutraceutical, adjunct agent highlights need for interdisciplinary collaboration between researchers, clinicians, regulatory bodies.

Language: Английский

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Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review

Applied Biosciences, Journal Year: 2024, Volume and Issue: 3(3), P. 392 - 425

Published: Sept. 22, 2024

The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate highly favorable to the synthesis of phenolic compounds, stored leaves; their consumption has been linked a lower cancer and cardiovascular disorders for which research interest upon this feature increased last decade. This study aimed (i) review evidence about importance leaf extract (OLE) on human health physiological effect its major compounds; (ii) update state art studies conducted technological usage extract; (iii) report potential uses OLE pharmaceuticals, food production, cosmetics; (iv) prospect future clinical applications from diverse cultivars, especially metabolic inflammatory conditions such as polycystic ovary syndrome (PCOS). Overall, cultivars richer TPC, including TFC, αT, omega-3 omega-9, present main target supplementation alone or conjunction vitaminic due nutraceutical value disorders, chronic diseases, anti-aging treatments, whereas less water content might be useful substrates preservation. With regard prospects, it would great clarify specific mechanisms underlying beneficial effects neuro-immune design safer healthier nature-based medicine wide array costly prevalent metabolic-related syndromes, namely, PCOS.

Language: Английский

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Supporting Neurologic Health with Mushroom Nutrition

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1568 - 1568

Published: May 2, 2025

Due to the extensive types of etiologies and risks causing over 600 mental health issues, convene adequate recommendations in primary care is a difficult assignment. The starting point for preventive interventions on neurologic disorders involves scrutinizing risk factors while targeting multiple hazards order increase success an early precautionary mediation plan action. factor most neurodegenerative diseases increasing worldwide median age, although one seven youngsters also experience disability, namely depression, representing decline well-being conferring considerable global public challenge. brain operates optimally when supported by holistic approach engaging several aspects, diet becoming integral part strategies. Treatment presently dominated pharmacotherapy, but additional strategies are needed prevent treat disorders. Dietary modification can prove be cost-effective strategy prevention and, certain conditions, treatment neurological Molecules dietary ingredients, micronutrients, phytonutrients, additives may modulate depression associated biomarkers. Nutritional exposure during developmental stages maternal impact, lifestyles, modulation gut microbiota through as novel therapies various neuropsychiatric conditions gaining interest maintaining health. Bioactive substances present different mushroom species have been ascribed both direct indirect mechanisms influence neurobehavior, here we support recognition nutrition influential element management some concerns. Scientific evidence demonstrating unequivocal link between nutritional mushrooms cognitive only beginning emerge, medicine should considered care.

Language: Английский

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The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

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Novel insights into dietary bioactive compounds and major depressive disorders: evidence from animal studies and future perspectives

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Enzyme ChE, cholinergic therapy and molecular docking: Significant considerations and future perspectives

International Journal of Immunopathology and Pharmacology, Journal Year: 2024, Volume and Issue: 38

Published: Jan. 1, 2024

Enzyme Che plays an essential role in cholinergic and non-cholinergic functions. It is present the fertilized/unfertilized eggs sperm of different species. Inclusion criteria for data collection from electronic databases NCBI Google Scholar are enzyme AChE/BChE, therapy, genomic organization gene transcription, structure, biogenesis, transport, processing localization, molecular signaling biological function, polymorphism influencing factors. acts as a receptor during hematopoiesis, protein adhesion, amyloid fiber formation, neurite outgrowth, bone development, maturation, explaining activity out synaptic neurotransmission. Polymorphism genes correlates to various diseases diverse drug responses. In particular, change accompanies cancer, neurodegenerative, cardiovascular disease. Literature knowledge indicates importance inhibitors that influence biochemical pathways disease treatment, organization, processing, localization enzyme. changes indicate possibility efficient new inhibitor target mechanisms research areas.

Language: Английский

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Carob (Ceratonia siliqua) leaves: A comprehensive analysis of bioactive profile and health-promoting potential of an untapped resource

Food Chemistry, Journal Year: 2024, Volume and Issue: 468, P. 142392 - 142392

Published: Dec. 9, 2024

Carob is a resilient plant with ecological and nutritional significance. A comprehensive study of Ceratonia siliqua leaves (CSL) was conducted to explore its chemical composition health-promoting potential, aiming at improving the carob-crop sustainability through valorization this untapped co-product. UHPLC-DAD-HRMS/MS quali-quantitative profiling CSL revealed high levels n-galloylated glucoses (129-196 mg g

Language: Английский

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Mechanistic Insights of Neuroprotective Efficacy of Verapamil-Loaded Carbon Quantum Dots against LPS-Induced Neurotoxicity in Rats

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7790 - 7790

Published: July 16, 2024

Alzheimer’s disease (AD) is a neurodegenerative that badly impacts patients and their caregivers. AD characterized by deposition of amyloid beta (Aβ) phosphorylated tau protein (pTau) in the brain with underlying neuroinflammation. We aimed to develop neuroprotective paradigm loading verapamil (VRH) into hyaluronic acid-modified carbon quantum dots (CQDs) comparing its effectiveness free form an AD-like model rats induced lipopolysaccharide (LPS). The experimental were divided seven groups: control, LPS, CQDs, early VRH (FVRH), late FVRH, (VCQDs), VCQDs. Characterizations VCQDs, behavioral performance rats, histopathological immunohistochemical changes, some hallmarks, oxidative stress biomarkers, neuro-affecting genes, DNA fragmentation determined. was successfully loaded which confirmed measured parameters. showed enhancement cognitive functions, disruption architecture brain, decreased Aβ pTau, increased antioxidant capacity, modifiable expression decline fragmentation. therapy superior drug. Moreover, intervention better than late, confirming implication detected molecular targets development AD. multifaceted mechanisms combating LPS-induced neurotoxicity through anti-inflammatory properties, thereby mitigating hallmarks Additionally, synthesized nanosystem approach exhibited neuroprotection owing advantages offered CQDs. However, finding new actionable biomarkers decisive importance improve outcomes for

Language: Английский

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Exploring the molecular mechanisms of curcumin in modulating memory impairment in neurodegenerative disorders

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)

Published: Dec. 9, 2024

Language: Английский

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The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13338 - 13338

Published: Dec. 12, 2024

Resveratrol, a naturally occurring polyphenolic compound found in various plants, has been extensively studied for its broad spectrum of beneficial biological effects. These encompass potent antioxidant properties, anti-inflammatory activities, anti-aging capabilities, cardioprotective functions, and neuroprotective potential. The diverse actions resveratrol extend beyond these well-established properties. It also exerts significant impact on metabolic processes bioavailability, critically, it demonstrates the ability to effectively traverse blood–brain barrier. This capacity penetrate central nervous system renders promising therapeutic agent management malignancies, as shown inhibit tumor cell proliferation, induce apoptosis, modulate key signaling cascades, such PI3K/Akt, JAK/STAT, NF-kB. multifaceted nature resveratrol’s effects, including influence physiological processes, underscores potential valuable option treatment tumors.

Language: Английский

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