Difference in the Intestinal Microbiota between Breastfeed Infants and Infants Fed with Artificial Milk: A Systematic Review

Pathogens, Год журнала: 2024, Номер 13(7), С. 533 - 533

Опубликована: Июнь 24, 2024

The gut microbiota (GM) plays a crucial role in human health, particularly during the first years of life. Differences GM between breastfed and formula (F)-fed infants may influence long-term health outcomes. This systematic review aims to compare with that F-fed evaluate clinical implications these differences. We searched databases on Scopus, Web Science, Pubmed following keywords: “gut microbiota”, microbiome”, “neonatal milk”. inclusion criteria were articles relating analysis intestinal microbiome newborns relation type nutrition, studies or case series, excluding reviews, meta-analyses, animal models, vitro studies. screening phase ended selection 13 publications for this work. Breastfed showed higher levels beneficial bacteria such as Bifidobacterium Lactobacillus, while had prevalence potentially pathogenic bacteria, including Clostridium difficile Enterobacteriaceae. Infant feeding influences composition oral significantly. Breastfeeding promotes healthier more diverse microbial ecosystem, which offer protective benefits. Future research should explore strategies improve understand implications.

Язык: Английский

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Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications

World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(2)

Опубликована: Янв. 18, 2025

Mammalian milk contains a variety of complex bioactive and nutritional components microorganisms. These microorganisms have diverse compositions functional roles that impact host health disease pathophysiology, especially mastitis. The advent use high throughput omics technologies, including metagenomics, metatranscriptomics, metaproteomics, metametabolomics, as well culturomics in microbiome studies suggest strong relationships between phenotype signatures While single undoubtedly contributed to our current understanding mastitis, they often provide limited information, targeting only biological viewpoint which is insufficient system-wide information necessary for elucidating the footprints molecular mechanisms driving mastitis dysbiosis. Therefore, integrating multi-omics approach research could generate new knowledge, improve structural ecosystem, insights sustainable control management.

Язык: Английский

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Breastfeeding and Health Benefits for the Mother-Infant Dyad: A Perspective on Human Milk Microbiota

Annals of Nutrition and Metabolism, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Фев. 6, 2025

Background:: Current scientific research on breastfeeding provides substantial evidence of its numerous positive impacts, not only for children in both the short and long term but also mothers who engage breastfeeding. Summary:: In addition to gold standard effect human milk infant nutrition, is associated with a lower incidence infections, reduced infant/childhood mortality, necrotizing enterocolitis, obesity during childhood later life, better cognitive performance, higher IQ score. For mothers, prolongs lactational amenorrhea, may facilitate postpartum weight loss, reduce breast ovarian cancers cardiovascular diseases. Breastfeeding can play beneficial role preventing antibiotic resistance, which global concern across all age groups. Implementing exclusive infants has potential enhance child development decrease healthcare expenses, leading economic savings individual families society. Human biologically active food that functions as prebiotic probiotic because oligosaccharides composition microbiota, act synergistic synbiotics.

Язык: Английский

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A comprehensive review of the characterization, host interactions, and stabilization advancements on probiotics: Addressing the challenges in functional food diversification

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(5)

Опубликована: Авг. 13, 2024

The demand for functional food is rising in tandem with the prevalence of chronic diseases. Probiotics play a crucial role development, yet their ability to confer health benefits host remains topic debate according Food and Agriculture Organization/World Health Organization requirements. application culturomics, innovative isolation techniques, within realm probiotics increasingly deemed essential fully harnessing latent potential microbial reservoirs. Nevertheless, its confined predominantly human fecal sources. Following integration probiogenomics, significant advancements have been made safety assessment probiotics. However, adoption novel probiotic microorganisms has match requisite pace. Progress research concerning host-probiotic interactions by employing omics technologies, particularly animal models, notable. Nonetheless, comprehensive elucidation mechanisms action trial studies are lagging behind. Additionally, viability probiotics, spanning from production as foods transit colon, markedly improved through encapsulation techniques. opportunities exploration persist regarding alternative coating materials diverse methodologies. Furthermore, there discernible transition domain probiotic-based foods, shifting away primarily dairy-centric focus toward inclusion broader array categories. This review addresses critical issues ranging sources techniques final developments. while doing so, it explores probiogenomics applications characterization, investigations into interactions, strategies stabilization under harsh environmental conditions.

Язык: Английский

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Genomic characteristics and phylogenetic relationships of Cutibacterium acnes breast milk isolates

BMC Microbiology, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 6, 2025

Cutibacterium acnes is one of the most commonly found microbes in breast milk. However, little known about genomic characteristics C. isolated from In this study, sequencing and assembly results 10 isolates milk were compared with data 454 strains downloaded NCBI, various perspectives, including phylogeny, characteristics, virulence genes, drug resistance carbohydrate utilization, elucidated. The findings study revealed no differences between other terms features, phylogenetic relationships, virulence, resistance-related genes. milk-derived exhibited significantly lower copies metabolic enzyme genes GT5 GT51 (P < 0.05) a higher copy number GH31 gene than others. primarily consists three genetic branches (A, B, C), which correspond to subspecies (C. subsp. elongatum, defendens, acnes). B C smaller that branch A. Branches A carry enzymes, CE1, CE10, GH3, CBM32 possess enzymes PL8 GH23, are absent Core core intergenic regions, concatenated sequences regions construct tree, it was could be used describe relationships. It therefore speculated originates nipple or surface. This provides novel basis for differentiation Breast had GT51, GH31. corresponding subspecies. more can relationships acnes.

Язык: Английский

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Human Milk Archaea Associated with Neonatal Gut Colonization and Its Co-Occurrence with Bacteria

Microorganisms, Год журнала: 2025, Номер 13(1), С. 85 - 85

Опубликована: Янв. 4, 2025

Archaea have been identified as early colonizers of the human intestine, appearing from first days life. It is hypothesized that origin many these archaea through vertical transmission during breastfeeding. In this study, we aimed to characterize archaeal composition in samples mother-neonate pairs observe potential transmission. We performed a cross-sectional study characterizing diversity 40 colostrum-neonatal stool by next-generation sequencing V5-V6 16S rDNA libraries. Intra- and inter-sample analyses were carried out describe Archaeal each sample type. Human colostrum neonatal stools presented similar core microbiota, mainly composed methanogens Methanoculleus Methanosarcina. Beta metabolic prediction results suggest homogeneity between types. Further, co-occurrence network analysis showed associations Bacteria, which might be relevant for organisms' presence milk ecosystems. According relative abundance proportions, beta diversity, analyses, similarities found imply there Nonetheless, differential abundances types other sources colonizing gut.

Язык: Английский

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Mammalian Lactation as a Framework for Teaching Development, Physiology, and Cell Biology for Social Change

Developmental Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Cervicovaginal Microbiome: Physiology, Age-Related Changes, and Protective Role Against Human Papillomavirus Infection

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(5), С. 1521 - 1521

Опубликована: Фев. 24, 2025

Background/Objectives: Persistent high-risk human papillomavirus (HPV) infections are the leading cause of cervical cancer. Developing evidence suggests that cervicovaginal microbiome plays a significant role in modulating HPV persistence and progression to neoplasia. This review synthesizes current knowledge on interplay between local immunity infections, emphasizing microbial diversity, immune responses, potential therapeutic implications. Methods: A thorough literature was performed using Embase, PubMed, Scopus, Google Scholar, encompassing studies published 2000 2024. Studies examining composition microbiome, HPV-related outcomes were evaluated synthesized into comprehensive review. Results: Lactobacillus-dominant particularly with L. crispatus, creates protective environment through lactic acid production, maintenance low pH, anti-inflammatory modulation, facilitating clearance. Dysbiosis, often characterized by dominance iners overgrowth anaerobic bacteria, fosters chronic inflammation, cytokine imbalance, microenvironment conducive progression. Hormonal changes menopause exacerbate these shifts, increasing risk lesions. suggest profiles antimicrobial peptides significantly influence further infection outcomes. Conclusions: The is critical determinant outcomes, for enhance responses prevent Personalized microbiome-targeted therapies may offer novel avenue managing reducing cancer incidence.

Язык: Английский

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The Role of Microbiome in Nervous and Immune System Development

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Dificultades técnicas en la lactancia materna

Опубликована: Март 29, 2025

El pediatra debe estar capacitado para detectar y poner medidas de apoyo a la lactancia natural evitar un destete no deseado. La leche materna es el alimento óptimo forma exclusiva durante los seis primeros meses vida. Debería mantenerse hasta dos años edad, complementándose con otros alimentos. Como objetivo este trabajo, se analizan las dificultades más comunes realizan propuestas abordaje dolor, grietas, ingurgitación, alteraciones del pezón, obstrucción conducto lácteo, mastitis absceso mamario. Los problemas técnicos que presentan en tienen origen común: vaciado incompleto pecho por diversas causas. Para intervenir adecuada, imprescindible realizar una anamnesis exploración madre, niño toma. agarre puede ser causa inicial comunes. Las recomendaciones seguir basan unas prevención esenciales desde nacimiento.

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