Caveolin and NOS in the Development of Muscular Dystrophy DOI Open Access

Moeka Nakashima,

Naoko Suga,

Sayuri Yoshikawa

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8771 - 8771

Опубликована: Авг. 12, 2024

Caveolin is a structural protein within caveolae that may be involved in transmembrane molecular transport and/or various intercellular interactions cells. Specific mutations of caveolin-3 muscle fibers are well known to cause limb–girdle muscular dystrophy. Altered expression has also been detected Duchenne dystrophy, which part the pathological process leading weakness. Interestingly, it shown renovation nitric oxide synthase (NOS) sarcolemma with dystrophy could improve health, suggesting NOS pathology Here, we summarize notable function caveolin skeletal and discuss their involvement as possible tactics for innovative treatment dystrophies.

Язык: Английский

Tea (Camellia sinensis) Seed Saponins Act as Sebosuppression Agents via the AMPK/mTOR Pathway DOI Creative Commons
Jian Li,

Y. S. Huang,

Jiagang Deng

и другие.

Journal of Cosmetic Dermatology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 1, 2025

ABSTRACT Background Excessive lipogenesis of the skin triggers some dermatological concerns, such as enlarged pores, acne, and blackheads. Although topical drug treatments can offer temporary relief, their prolonged usage may lead to side effects dryness, irritation, or allergic reactions. Consequently, development safer efficacious ingredients in cosmetics for managing sebum overproduction represents a significant yet challenging endeavor. Aim Saponins were extracted from tea ( Camellia sinensis ) seed meal purified by macroporous resin order investigate impact saponins (TSS) on lipid production human immortalized sebaceous cells. Moreover, we attempted reveal underlying mechanism TSS sebosuppression effect SZ95 sebocytes stimulated linoleic acid (LA). Methods The compositions chemical structures determined using UV–vis absorption spectrum, Fourier transform‐infrared (FTIR) ultra‐high‐performance liquid chromatography‐mass spectrometry analysis. An vitro model cellular accumulation induced LA was established. Total synthesis intracellular assessed through Nile Red staining, while triglyceride, cholesterol, fatty acids quantified commercially assay kits. Western blot quantitative real‐time polymerase chain reaction employed analyze protein expression levels involved AMP‐activated kinase (AMPK)/mammalian target rapamycin (mTOR) pathway well downstream mRNA expressions sterol regulatory element‐binding protein‐1 (SREBP‐1), peroxisome proliferator‐activated receptor γ (PPARγ), synthase (FAS). localizations SREBP‐1 within cytoplasm nucleus characterized immunofluorescence staining. Results Five identified TSS, all which oleanic acid‐type pentacyclic triterpenes. treatment significantly alleviated LA‐induced sebocytes. In addition, activated AMPK/mTOR downregulated transcription factors enzymes, including SREBP‐1, PPARγ, FAS. blocked nuclear transfer nucleus. Conclusion sebocytes, exhibited sebosuppressive revealed inhibited total lipids acids. anti‐lipogenesis activation enzymes Additionally, translocation. These results justify potent new candidate modulating

Язык: Английский

Процитировано

1
Saponin components exhibit antiviral properties against porcine epidemic diarrhea virus in vitro DOI

Yiyi Hu,

Yunchuan Li, Haodan Zhu

и другие.

RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Four saponins could efficiently modulate the immune response against PEDV and hold promise for utilization in antiviral treatments.

Язык: Английский

Процитировано

0
Phytochemical Composition of Ziziphus lotus (L.) Lam and Its Impact on the Metabolic Syndrome: A Review DOI Creative Commons
Chaimae Alla, Amanat Ali, Afaf Mehiou

и другие.

Advances in Pharmacological and Pharmaceutical Sciences, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

The long‐term pathological state known as metabolic syndrome is characterized by hypertension, insulin resistance diabetes, abdominal obesity, and hyperlipidemia. Seeking healthcare strategies with fewer side effects, such herbal remedies, preferable in terms of mitigating the negative consequences synthetic medications. Ziziphus lotus (L.) (Rhamnaceae) or wild jujube, commonly “Sedra,” one best choices it contains a variety phytochemicals biologically active compounds. Several flavonoids stilbenes have been recognized primary bioactive components including rutin, hyperin, isoquercitrin, resveratrol. These polyphenols are pharmacologically broad‐spectrum beneficial effects for reducing risk factors associated syndrome. They exhibit antioxidant anti‐inflammatory properties, regulate lipid metabolism, possess antiobesity, antihypertensive, antidiabetic characteristics. However, there certain limitations to their therapeutic application, low bioavailability. Various proposed enhance pharmacokinetic profile potential future use. main goal this review explore underlying mechanisms related jujube its compounds treatment prevention

Язык: Английский

Процитировано

0
Probiotics for the treatment of hyperlipidemia: Focus on gut-liver axis and lipid metabolism DOI Creative Commons
Min You, Liping Zhou, Fan Wu

и другие.

Pharmacological Research, Год журнала: 2025, Номер 214, С. 107694 - 107694

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0
Caveolin and NOS in the Development of Muscular Dystrophy DOI Open Access

Moeka Nakashima,

Naoko Suga,

Sayuri Yoshikawa

и другие.

Опубликована: Июль 2, 2024

Caveolin is a structural protein within caveolae, which may be involved in transmembrane molecular transport and/or various intercellular interactions cells. Specific mutations of caveolin-3 muscle cells are well-known to cause limb-girdle muscular dystrophy. Altered expression the has been also detected Duchenne's dystrophy, part pathological process leading weakness. Interestingly, it shown that renovation nitric oxide synthase (NOS) sarcolemma with dystrophy could improve health, suggesting NOS pathology Here, we summarize notable function caveolin skeletal cells, and would like discuss about their involvement as well possible tactics for innovative treatment dystrophies.

Язык: Английский

Процитировано

3
Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers DOI Creative Commons

Uchechukwu Edna Obianwuna,

Xinyu Chang,

V. U. Oleforuh-Okoleh

и другие.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 9, 2024

Язык: Английский

Процитировано

2
Caveolin and NOS in the Development of Muscular Dystrophy DOI Open Access

Moeka Nakashima,

Naoko Suga,

Sayuri Yoshikawa

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8771 - 8771

Опубликована: Авг. 12, 2024

Caveolin is a structural protein within caveolae that may be involved in transmembrane molecular transport and/or various intercellular interactions cells. Specific mutations of caveolin-3 muscle fibers are well known to cause limb–girdle muscular dystrophy. Altered expression has also been detected Duchenne dystrophy, which part the pathological process leading weakness. Interestingly, it shown renovation nitric oxide synthase (NOS) sarcolemma with dystrophy could improve health, suggesting NOS pathology Here, we summarize notable function caveolin skeletal and discuss their involvement as possible tactics for innovative treatment dystrophies.

Язык: Английский

Процитировано

1