Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.
Phytomedicine Plus,
Год журнала:
2025,
Номер
unknown, С. 100754 - 100754
Опубликована: Янв. 1, 2025
Язык: Английский
Ashwagandha’s Multifaceted Effects on Human Health: Impact on Vascular Endothelium, Inflammation, Lipid Metabolism, and Cardiovascular Outcomes—A Review
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2481 - 2481
Опубликована: Июль 31, 2024
,
commonly
known
as
Ashwagandha,
has
been
popular
for
many
years.
Numerous
studies
have
shown
that
the
extract
of
this
plant,
due
to
its
wealth
active
substances,
can
induce
anti-inflammatory,
neuroprotective,
immunomodulatory,
hepatoprotective,
cardioprotective,
anti-diabetic,
adaptogenic,
anti-arthritic,
anti-stress,
and
antimicrobial
effects.
This
review
examines
impact
Ashwagandha
on
vascular
endothelium,
inflammation,
lipid
metabolism,
cardiovascular
outcomes.
Studies
extracts
exhibit
an
anti-angiogenic
effect
by
inhibiting
endothelial
growth
factor
(VEGF)-induced
capillary
sprouting
formation
lowering
mean
density
microvessels.
Furthermore,
results
numerous
highlight
anti-inflammatory
role
extract,
action
plant
causes
a
decrease
in
expression
pro-inflammatory
cytokines.
Interestingly,
withanolides,
present
root,
ability
inhibit
differentiation
preadipocytes
into
adipocytes.
Research
also
proved
Язык: Английский
Exploring Withanolides from Withania somnifera: A Promising Avenue for Alzheimer’s Disease Treatment
Current Pharmacology Reports,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 7, 2025
Язык: Английский
Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes
European Journal of Sport Science,
Год журнала:
2025,
Номер
25(3)
Опубликована: Фев. 15, 2025
ABSTRACT
Ashwagandha
is
a
supplement
with
the
potential
to
improve
exercise
performance.
However,
research
on
its
impact
female
athletes
remains
limited.
This
study
investigates
effects
of
ashwagandha
recovery
and
muscle
strength
in
professional
athletes,
addressing
gap
understanding
role
this
underrepresented
population.
Female
footballers
were
randomly
assigned
600
mg/day
root
extract
group
(ASH,
n
=
15;
age:
26.0
±
4.9
years,
height:
1.66
0.1
m,
body
mass:
61.5
7.5
kg,
career:
15.2
7.4
years)
or
placebo
(PLA,
23.5
5.5
6.0
13.1
years).
Recovery
was
assessed
total
quality
(TQR),
Hooper
Index
(HI)
rate
perceived
exertion
(RPE).
Strength
by
hand
grip,
medicine
ball
throw
(MBT),
countermovement
jump
(CMJ)
peak
power.
Dietary
intake
recorded
prior
baseline
measurements.
Repeated
measures
ANOVA,
Bonferroni
test,
independent
t
‐tests
ANCOVA
used
analysis.
A
significant
×
time
interaction
effect
found
for
TQR
(
p
0.026),
post‐hoc
analysis
revealing
difference
between
ASH
PLA
at
28
days
0.039).
Perceived
sleep
from
HI
improved
significantly
compared
0.038),
change
14
days.
The
highlighted
influence
carbohydrate
grip
0.005),
MBT
<
0.001)
mass
0.001).
dosage
mg
may
enhance
footballers.
Future
should
investigate
optimal
test
across
broader
range
athletic
populations.
Trials
Registration:
trial
registered
ClinicalTrials.gov
ID
NCT06264986
Язык: Английский
Effects of Supplementation with a Microalgae Extract from Phaeodactylum tricornutum Containing Fucoxanthin on Cognition and Markers of Health in Older Individuals with Perceptions of Cognitive Decline
Nutrients,
Год журнала:
2024,
Номер
16(17), С. 2999 - 2999
Опубликована: Сен. 5, 2024
Phaeodactylum
tricornutum
(PT)
is
a
microalgae
extract
that
contains
fucoxanthin
and
has
been
shown
to
enhance
cognitive
function
in
younger
populations.
The
present
study
assessed
if
PT
supplementation
affects
cognition
healthy,
young-old,
physically
active
adults
with
self-perceptions
of
memory
decline.
Methods:
Forty-three
males
females
(64.3
±
6.0
years,
79.8
16.0
kg,
27.0
4.0
kg/m2)
perceptions
decline
completed
the
double-blind,
randomized,
parallel-arm,
placebo-controlled
intervention
clinical
trial.
Participants
were
counterbalanced
by
sex
BMI
randomly
allocated
their
respective
12-week
interventions,
which
either
placebo
(PL)
or
1100
mg/day
containing
8.8
mg
(FX).
Fasting
blood
samples
collected,
assessments
performed
during
testing
session
at
0,
4,
12
weeks
intervention.
data
analyzed
multivariate
univariate
general
linear
model
(GLM)
analyses
repeated
measures,
pairwise
comparisons,
mean
changes
from
baseline
analysis
95%
confidence
intervals
(CIs)
assess
significance
findings.
Results:
FX
significantly
affected
(p
<
0.05)
exhibited
tendencies
toward
>
0.05
p
0.10
effect
sizes
ranging
medium
large)
for
word
recall,
picture
recognition
reaction
time,
Stroop
color–word
test,
choice
digit
vigilance
test
variables.
Additionally,
promoted
more
consistent
improvement
values
when
examining
CIs,
although
most
differences
seen
over
time
rather
than
between
groups.
Conclusions:
results
demonstrate
some
evidence
can
improve
working
secondary
memory,
vigilance,
attention,
accuracy,
executive
function.
There
was
also
positive
effects
on
insulin
sensitivity
about
sleep
quality
no
negative
panels
perceived
side
effects.
Additional
research
should
investigate
how
may
affect
individuals
perceiving
Registered
trial
#NCT05759910.
Язык: Английский
Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3836 - 3836
Опубликована: Ноя. 8, 2024
Withania
somnifera
(common
name:
ashwagandha;
WS)
is
an
Ayurvedic
botanical
that
has
become
popular
for
its
reputed
effects
on
stress
and
insomnia.
Research
into
the
bioactive
compounds
responsible
biological
of
WS
largely
focused
withanolides,
a
group
steroidal
lactones
commonly
found
in
Solanaceae
family.
Until
recently,
however,
it
was
unclear
which,
if
any,
withanolides
were
present
plasma
after
ingestion
products.
The
aim
this
review
to
summarize
current
knowledge
regarding
pharmacokinetics
analytical
methods
developed
detect
them
plasma.
Twenty
studies
(sixteen
animal,
four
human)
identified
which
isolated
or
withanolide-containing
products
administered
animals
humans
quantified
Withanolides
analyzed
using
reversed-phase
liquid
chromatography
coupled
mass
spectrometry.
Plasma
concentrations
varied
significantly
depending
substance
administered,
withanolide
dose,
route
administration.
withaferin
A,
B,
withanoside
IV,
12-deoxywithastramonolide,
withanone
have
been
reported
rodents
(Cmax
range:
5.6–8410
ng/mL),
while
IV
pharmacokinetic
parameters
described
0.1–49.5
ng/mL).
Язык: Английский
Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
Journal of Psychoactive Drugs,
Год журнала:
2024,
Номер
unknown, С. 1 - 13
Опубликована: Ноя. 5, 2024
This
prospective,
randomized,
placebo-controlled
study
assessed
the
effects
of
Ashwagandha
root
extract
(ARE)
on
cognition,
energy,
and
mood
in
adults
with
self-reported
cognitive
energy
problems.
Healthy
subjects
aged
30–75
years
were
randomized
to
receive
ashwagandha
(Withania
somnifera)
600
mg/day
(n
=
60)/identical
placebo
60)
orally
for
8
weeks.
Cognitive
function
was
at
baseline
week
using
a
Computerized
Mental
Performance
Assessment
System
(COMPASS).
Secondary
outcomes
Profile
Mood
States
Abbreviated
Version
(POMS-A),
Fatigue
Scale
(MFS)
Behavior
Rating
Inventory
Executive
Function-Adult
(BRIEF-A)
mood,
mental
fatigue
executive
function,
respectively,
baseline,
4
8.
Greater
improvement
(p
<
.05)
from
scores
seen
ARE
as
against
COMPASS
items
episodic
memory,
working
memory
accuracy
attention.
also
improved
POMS-A,
MFS
BRIEF-A
suggesting
an
vigor,
increase
functioning
respectively
ARE.
The
herb
well
tolerated
had
good
patient
compliance
no
serious
adverse
events
reported
either
groups.
suggests
that
dose
mg
day
can
improve
Язык: Английский
Health-related Messages about Herbs, Spices and Other Botanicals Appearing in Print Issues and Websites of Legacy Media: Content Analysis and Evaluation (Preprint)
JMIR Formative Research,
Год журнала:
2024,
Номер
8, С. e63281 - e63281
Опубликована: Ноя. 5, 2024
Background
Legacy
media
are
publications
that
existed
before
the
internet.
Many
of
these
have
migrated
to
a
web
format,
either
replacing
or
in
parallel
their
print
issues.
Readers
place
an
economic
value
on
access
information
presented
as
they
pay
for
subscriptions
and
higher
degree
trust
content.
Much
has
been
written
about
inaccurate
misleading
health
social
media;
however,
content
accuracy
contained
legacy
not
examined
detail.
Discussion
herbs,
spices,
other
botanicals
absent
from
this
context.
Objective
The
objectives
study
were
(1)
identify
associations
botanical
products
mentioned
targeted
range
demographic
groups
(2)
evaluate
against
published
scientific
studies.
Methods
In
total,
10
popular
magazines
targeting
gender,
race/ethnicity,
sexual
orientation
selected
analysis.
Relevant
was
extracted
coded
over
1
year.
Associations
between
specific
factors
identified.
For
most
frequent
botanical–health
application
associations,
PubMed
search
conducted
reviews
corresponding
each
item’s
indicated
applications.
Where
no
systematic
available,
single
research
studies
sought.
Results
A
total
237
unique
There
128
mentions
issues
1215
websites.
18
applications
identified
used
categorize
uses
various
individually
general
categories.
frequently
skin
care,
with
913
mentions,
immunity
enhancement,
705
gastrointestinal
probiotics,
184
cognitive
function
(stress
mental
health),
106
mentions.
Comparison
literature
evaluating
efficacy
functions
positive
support
aloe
vera,
argan
oil,
chamomile,
jojoba
lavender,
rosemary,
tea
tree
oil
care.
Berries,
ginger,
turmeric,
green
had
strongest
evidence
role
enhancement.
Ginger
oats
supported
having
health.
Finally,
berries,
ashwagandha,
cannabidiol
managing
stress.
Other
items
such
mushrooms
less
strongly
supported.
Conclusions
prevalent
indicates
that,
overall,
consistent
current
reports
products.
While
some
greater
than
others,
truly
egregious
falsehoods
absent.
Therefore,
may
be
considered
credible
source
readers
topics.
Язык: Английский
Editorial: The Effect of Nutrients on Neurological Disorders
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4016 - 4016
Опубликована: Ноя. 23, 2024
The
prevalence
of
neurological
disorders
(NDs)
is
increasing,
with
great
cost
to
public
health
[...].
Язык: Английский
Impact of a Withania somnifera and Bacopa monnieri Formulation on SH-SY5Y Human Neuroblastoma Cells Metabolism Through NMR Metabolomic
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4096 - 4096
Опубликована: Ноя. 28, 2024
Objectives:
This
study
investigates
the
effectiveness
of
an
herbal
formulation,
STRESSLESS
(ST-65),
which
combines
ashwagandha
(Withania
somnifera)
and
bacopa
(Bacopa
monnieri),
on
SH-SY5Y
human
neuroblastoma
cells.
Given
rising
interest
in
natural
compounds
for
neuroprotection
stress
alleviation,
we
aimed
to
explore
cellular
molecular
effects
this
formulation.
Methods:
Utilizing
a
nuclear
magnetic
resonance
(NMR)
metabolomic
approach
ultra-high-performance
liquid
chromatography-high-resolution
mass
spectrometry
(UHPLC-HRMS),
identified
key
bioactive
ST-65,
including
withanolides
from
bacosides
bacopa.
Results:
Our
findings
indicate
that
ST-65
treatment
significantly
alters
metabolic
profile
Key
changes
included
increased
levels
metabolites
linked
neuroprotection,
energy
metabolism,
antioxidant
defense.
Notable
enhancements
were
observed
specific
amino
acids
neuroprotective
compounds,
suggesting
activation
mechanisms
mitigation
stress-induced
damage.
Conclusions:
The
reveals
complex
phyto-chemical
underscores
its
potential
as
active
agent
addressing
stress-related
neurodegenerative
conditions.
These
insights
into
neuronal
provide
foundation
further
exploration
formulations
neuroprotection.
Язык: Английский