The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model DOI Creative Commons
Baoe Liu,

Chengya Huang,

Xin Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Chronic migraine is one of the most common pain disorders, characterized by significant disability and a lack safe, long‐term, effective treatment options. Recent studies highlight interaction between lung microbiota central nervous system. In this study, nitroglycerin (NTG)‐induced chronic model constructed in male C57BL/6 mice to explore these interactions. Notable alterations are observed migraine‐afflicted mice. Notably, there marked decrease Proteobacteria group, associated with short‐chain fatty acids 5‐hydroxytryptamine (5‐HT). After intratracheal injection neomycin, diversity altered, resulting relief migraines. This effect also that receive neomycin‐treated bronchoalveolar lavage fluid (BALF) transplantation, further demonstrating role process. The altered activate pulmonary vagus nerve via Brain‐derived neurotrophic factor‐tropomyosin receptor kinase B (BDNF‐TrkB) pathway lung, which projects nucleus solitary tract (NTS) dorsal raphe (DRN). activation, turn, stimulates 5‐HT neurons DRN, increased serotonin levels contribute model.

Language: Английский

Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon by Activating the BDNF-TrkB-PLC/IP3 Pathway to Reconstruct the Intestinal Nerve and Barrier DOI
Shengnan Zhu,

Qiangqing Yu,

Yifan Xue

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cathartic colon (CC) is a type of slow-transit constipation caused by patient's long-term use irritating laxatives. Probiotics play crucial role in managing constipation.

Language: Английский

Citations

0
The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model DOI Creative Commons
Baoe Liu,

Chengya Huang,

Xin Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Chronic migraine is one of the most common pain disorders, characterized by significant disability and a lack safe, long‐term, effective treatment options. Recent studies highlight interaction between lung microbiota central nervous system. In this study, nitroglycerin (NTG)‐induced chronic model constructed in male C57BL/6 mice to explore these interactions. Notable alterations are observed migraine‐afflicted mice. Notably, there marked decrease Proteobacteria group, associated with short‐chain fatty acids 5‐hydroxytryptamine (5‐HT). After intratracheal injection neomycin, diversity altered, resulting relief migraines. This effect also that receive neomycin‐treated bronchoalveolar lavage fluid (BALF) transplantation, further demonstrating role process. The altered activate pulmonary vagus nerve via Brain‐derived neurotrophic factor‐tropomyosin receptor kinase B (BDNF‐TrkB) pathway lung, which projects nucleus solitary tract (NTS) dorsal raphe (DRN). activation, turn, stimulates 5‐HT neurons DRN, increased serotonin levels contribute model.

Language: Английский

Citations

0