How follow-up period in prospective cohort studies affects the relationship between baseline fish consumption and risk of Alzheimer's disease and dementia
Journal of Alzheimer s Disease Reports,
Год журнала:
2025,
Номер
9
Опубликована: Янв. 1, 2025
Background
Diet
plays
an
important
role
in
the
risk
of
Alzheimer's
disease
(AD)
and
dementia.
Adherence
to
Mediterranean
diet
is
regarded
as
one
way
reduce
risk.
Fish
a
component
diet.
Participant
variables
change
with
time,
resulting
“regression
dilution”.
Objective
The
objective
investigate
follow-up
period
after
measurement
dietary
fish
intake
AD
Methods
A
recent
meta-analysis
prospective
cohort
studies
used
examine
this
effect
for
incidence
dementia
AD.
Results
For
seven
mean
periods
from
ten
years,
regression
fit
data
relative
(RR)
=
0.19
+
(0.087
×
Follow
up
[years],
r
0.84,
adjusted
2
0.66,
p
0.009).
However,
when
age
participants
was
added
analysis,
became
non-significant.
five
3.9
9.8
RR
0.11
(0.095
follow
[years]),
0.93,
0.87,
0.02).
shortest
are
40%
greater
than
standard
suggests
70%
Conclusions
Prospective
health
outcomes
should
reassess
every
few
years.
Meta-analyses
consider
during
up.
Язык: Английский
How Follow-Up Period in Prospective Cohort Studies Affects Relationship Between Baseline Serum 25(OH)D Concentration and Risk of Stroke and Major Cardiovascular Events
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3759 - 3759
Опубликована: Ноя. 1, 2024
Prospective
cohort
studies
are
useful
for
studying
how
biomolecular
status
affects
risk
of
adverse
health
outcomes.
Less
well
known
is
that
the
longer
follow-up
time,
lower
association
(or
"apparent
effect")
due
to
"regression
dilution".
Here,
we
evaluate
interval
from
baseline
"event"
relationship
between
serum
25-hydroxyvitamin
D
[25(OH)D]
concentration
and
later
incidence
stroke
major
cardiovascular
events
(MACEs).
Язык: Английский