bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Дек. 25, 2022
SUMMARY
The
reduced
pathogenicity
of
the
omicron
BA.1
sub-lineage
compared
to
earlier
variants
is
well
described,
although
whether
such
attenuation
retained
for
later
like
BA.5
and
XBB
remains
controversial.
We
show
that
isolates
were
significantly
more
pathogenic
in
K18-hACE2
mice
than
a
isolate,
showing
increased
neuroinvasiveness,
resulting
fulminant
brain
infection
mortality,
similar
seen
original
ancestral
isolates.
also
infected
human
cortical
organoids
greater
extent
In
brains
mice,
neurons
main
target
infection,
neuronal
progenitor
cells
immature
infected.
Although
not
feature
COVID-19,
evidence
damage
some
COVID-19
patients
with
severe
disease
becoming
compelling,
results
herein
suggesting
evolving
may
have
increasing
intrinsic
neuropathogenic
potential.
ACS Chemical Neuroscience,
Год журнала:
2022,
Номер
13(23), С. 3213 - 3229
Опубликована: Ноя. 14, 2022
Necroptosis
is
a
type
of
precisely
regulated
necrotic
cell
death
activated
in
caspase-deficient
conditions.
Multiple
factors
initiate
the
necroptotic
signaling
pathway,
including
toll-like
receptor
3/4,
tumor
necrosis
factor
(TNF),
dsRNA
viruses,
and
T
receptors.
Presently,
TNF-induced
necroptosis
via
phosphorylation
three
key
proteins,
receptor-interacting
protein
kinase
1,
3,
mixed
lineage
domain-like
protein,
best-characterized
process.
induced
by
Z-DNA-binding
1
(ZBP-1)
toll/interleukin-1
(TIR)-domain-containing
adapter-inducing
interferon
(TRIF)
plays
significant
role
infectious
diseases,
such
as
influenza
A
virus,
Zika
herpesvirus
infection.
An
increasing
number
studies
have
demonstrated
close
association
with
multiple
disrupting
has
been
confirmed
to
be
effective
for
treating
(or
managing)
these
diseases.
The
central
nervous
system
(CNS)
exhibits
unique
physiological
structures
immune
characteristics.
may
occur
without
sequential
activation
signal
supporting
cells
more
important
implications
disease
development.
Additionally,
signals
can
absence
necroptosis.
Here,
we
summarize
its
proteins
CNS
diseases
characterize
typical
regulators
provide
basis
further
development
therapeutic
strategies
In
present
review,
relevant
information
consolidated
from
recent
(from
2010
until
present),
excluding
patents
this
field.
ImmunoHorizons,
Год журнала:
2022,
Номер
6(10), С. 716 - 721
Опубликована: Окт. 1, 2022
Abstract
Multiple
organ
damage
is
common
in
patients
with
severe
COVID-19,
even
though
the
underlying
pathogenic
mechanisms
remain
unclear.
Acute
viral
infection
typically
activates
type
I
IFN
(IFN-I)
signaling.
The
antiviral
role
of
IFN-I
well
characterized
vitro.
However,
our
understanding
how
regulates
host
immune
response
to
SARS-CoV-2
vivo
incomplete.
Using
a
human
ACE2-transgenic
mouse
model,
we
show
present
study
that
receptor
signaling
essential
for
protection
against
acute
lethality
mice.
Interestingly,
although
limits
replication
lung,
primary
site,
it
dispensable
efficient
clearance
at
adaptive
phase
infection.
Conversely,
found
absence
signaling,
extreme
animal
consistent
heightened
infectious
virus
and
prominent
pathological
manifestations
brain.
Taken
together,
results
this
demonstrate
required
restricting
neuroinvasion,
thereby
mitigating
COVID-19
severity.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 31, 2023
Abstract
The
reduced
pathogenicity
of
the
omicron
BA.1
sub-lineage
compared
to
earlier
variants
is
well
described,
although
whether
such
attenuation
retained
for
later
like
BA.5
remains
controversial.
We
show
that
a
isolate
was
significantly
more
pathogenic
in
K18-hACE2
mice
than
isolate,
with
infections
showing
increased
neuroinvasiveness,
resulting
brain
infection
and
mortality,
similar
seen
original
ancestral
isolates.
also
infected
human
cortical
organoids
greater
extent
In
brains
neurons
were
main
target
infection,
neuronal
progenitor
cells
immature
infected.
Evidence
damage
certain
COVID-19
patients
becoming
compelling,
results
herein
illustrating
increasing
intrinsic
neuropathogenic
potential
evolving
variants.
Pathogens,
Год журнала:
2022,
Номер
11(11), С. 1256 - 1256
Опубликована: Окт. 29, 2022
SARS-CoV-2
is
a
new
coronavirus
that
has
affected
the
world
since
2019.
Interstitial
pneumonia
most
common
clinical
presentation,
but
additional
symptoms
have
been
reported,
including
neurological
manifestations.
Severe
forms
of
infection,
especially
in
elderly
patients,
present
as
an
excessive
inflammatory
response
called
"cytokine
storm",
which
can
lead
to
acute
respiratory
distress
syndrome
(ARDS),
multiorgan
failure
and
death.
Little
known
about
relationship
between
outcomes
or
characteristics
virus-host
interactions.
The
aim
this
narrative
review
highlight
possible
links
involvement
damage
mediated
by
pathological
pathways
infection.
We
will
focus
on
neuro-immune
interactions
age-related
immunity
decline
discuss
some
mechanisms
contribute
negative
COVID-19
patients.
Furthermore,
we
describe
available
therapeutic
strategies
their
effects
symptoms.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Дек. 25, 2022
SUMMARY
The
reduced
pathogenicity
of
the
omicron
BA.1
sub-lineage
compared
to
earlier
variants
is
well
described,
although
whether
such
attenuation
retained
for
later
like
BA.5
and
XBB
remains
controversial.
We
show
that
isolates
were
significantly
more
pathogenic
in
K18-hACE2
mice
than
a
isolate,
showing
increased
neuroinvasiveness,
resulting
fulminant
brain
infection
mortality,
similar
seen
original
ancestral
isolates.
also
infected
human
cortical
organoids
greater
extent
In
brains
mice,
neurons
main
target
infection,
neuronal
progenitor
cells
immature
infected.
Although
not
feature
COVID-19,
evidence
damage
some
COVID-19
patients
with
severe
disease
becoming
compelling,
results
herein
suggesting
evolving
may
have
increasing
intrinsic
neuropathogenic
potential.
