Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders
Nutrients,
Год журнала:
2023,
Номер
15(21), С. 4631 - 4631
Опубликована: Окт. 31, 2023
The
gut–brain
axis
(GBA)
is
a
complex
bidirectional
communication
network
connecting
the
gut
and
brain.
It
involves
neural,
immune,
endocrine
pathways
between
gastrointestinal
(GI)
tract
central
nervous
system
(CNS).
Perturbations
of
GBA
have
been
reported
in
many
neurodegenerative
disorders
(NDDs),
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS),
among
others,
suggesting
possible
role
pathogenesis.
microbiota
pivotal
component
GBA,
alterations
its
composition,
known
dysbiosis,
associated
with
dysfunction
neurodegeneration.
might
influence
homeostasis
CNS
by
modulating
immune
and,
more
directly,
regulating
production
molecules
metabolites
that
systems,
making
it
potential
therapeutic
target.
Preclinical
trials
manipulating
microbial
composition
through
dietary
intervention,
probiotic
prebiotic
supplementation,
fecal
transplantation
(FMT)
provided
promising
outcomes.
However,
clear
mechanism
not
well
understood,
results
are
always
consistent.
Here,
we
provide
an
overview
major
components
approaches
targeting
to
ameliorate
NDDs.
Язык: Английский
Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(18)
Опубликована: Сен. 1, 2024
Abstract
Along
with
mounting
evidence
that
gut
microbiota
and
their
metabolites
migrate
endogenously
to
distal
organs,
the
‘gut–lung
axis,’
‘gut–brain
‘gut–liver
axis’
‘gut–renal
have
been
established.
Multiple
animal
recent
studies
demonstrated
may
also
be
a
key
susceptibility
factor
for
neurological
disorders
such
as
Alzheimer's
disease,
Parkinson's
disease
autism.
The
gastrointestinal
tract
is
innervated
by
extrinsic
sympathetic
vagal
nerves
intrinsic
enteric
nervous
system,
interacts
system
maintain
homeostatic
balance
in
host
gut.
A
total
of
1507
publications
on
interactions
between
microbiota,
gut–brain
axis
are
retrieved
from
Web
Science
investigate
underlying
mechanisms
involved
normal
states.
We
provide
comprehensive
overview
effects
its
function
neurotransmitter
secretion,
well
alterations
disorders,
basis
possibility
targeting
therapeutic
agent
disorders.
Язык: Английский
The Gut–Kidney Axis in Chronic Kidney Diseases
Diagnostics,
Год журнала:
2024,
Номер
15(1), С. 21 - 21
Опубликована: Дек. 25, 2024
The
gut–kidney
axis
represents
the
complex
interactions
between
gut
microbiota
and
kidney,
which
significantly
impact
progression
of
chronic
kidney
disease
(CKD)
overall
patient
health.
In
CKD
patients,
imbalances
in
promote
production
uremic
toxins,
such
as
indoxyl
sulfate
p-cresyl
sulfate,
impair
renal
function
contribute
to
systemic
inflammation.
Mechanisms
like
endotoxemia,
immune
activation
oxidative
stress
worsen
damage
by
activating
pro-inflammatory
pathways.
Insights
into
these
mechanisms
highlight
gut-derived
metabolites,
bacterial
translocation,
response
changes
on
health,
suggesting
new
potential
approaches
for
treatment.
Clinical
applications,
dietary
interventions,
prebiotics,
probiotics
fecal
transplantation,
are
promising
adjusting
alleviate
symptoms
slow
progression.
Current
research
highlights
clinical
relevance
axis,
but
further
study
is
essential
clarify
mechanisms’
diagnostic
biomarkers
optimize
therapeutic
interventions.
This
review
emphasizes
importance
an
integrated
approach
management,
focusing
a
target
limit
injury.
Язык: Английский
Unlocking the therapeutic potential of gut microbiota for preventing and treating aging-related neurological disorders
Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Radiation-Induced Brain Injury: Mechanistic Insights and the Promise of Gut–Brain Axis Therapies
Brain Sciences,
Год журнала:
2024,
Номер
14(12), С. 1295 - 1295
Опубликована: Дек. 23, 2024
Radiation
therapy
is
widely
recognized
as
an
efficacious
modality
for
treating
neoplasms
located
within
the
craniofacial
region.
Nevertheless,
this
approach
not
devoid
of
risks,
predominantly
concerning
potential
harm
to
neural
structures.
Adverse
effects
may
encompass
focal
cerebral
necrosis,
cognitive
function
compromise,
cerebrovascular
pathology,
spinal
cord
injury,
and
detriment
fibers
constituting
brachial
plexus.
With
increasing
survival
rates
among
oncology
patients,
evaluating
post-treatment
quality
life
has
become
crucial
in
assessing
benefits
radiation
therapy.
Consequently,
it
imperative
investigate
therapeutic
strategies
mitigate
complications
from
exposure.
Current
management
radiation-induced
damage
involves
corticosteroids
bevacizumab,
with
preclinical
research
on
antioxidants
thalidomide.
Despite
these
efforts,
optimal
treatment
remains
elusive.
Recent
studies
suggest
gut
microbiota’s
involvement
neurologic
pathologies.
This
review
aims
discuss
causes
existing
treatments
injury
explore
microbiota
modulation
a
strategy.
Язык: Английский
Importance of Fecal Microbiota Transplantation and Molecular Regulation as Therapeutic Strategies in Inflammatory Bowel Diseases
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4411 - 4411
Опубликована: Дек. 23, 2024
Noncoding
RNAs,
particularly
microRNAs
(miRNAs)
and
small
interfering
RNAs
(siRNAs),
have
emerged
as
key
players
in
the
pathogenesis
therapeutic
strategies
for
inflammatory
bowel
disease
(IBD).
MiRNAs,
endogenous
RNA
molecules
that
silence
target
mRNAs
to
regulate
gene
expression,
are
closely
linked
immune
responses
pathways
IBD.
Notably,
miR-21,
miR-146a,
miR-155
consistently
upregulated
IBD,
influencing
cell
modulation,
cytokine
production,
intestinal
epithelial
barrier.
These
miRNAs
serve
biomarkers
progression
severity,
well
targets
controlling
inflammation.
This
comprehensive
review
highlights
intricate
interplay
between
gut
microbiota,
fecal
microbiota
transplantation
(FMT),
miRNA
regulation.
It
concludes
FMT
influence
activity,
presenting
a
promising
avenue
personalized
IBD
treatment.
Язык: Английский