Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 364 - 364
Опубликована: Март 4, 2025
The
rising
burden
of
fungal
infections
presents
a
significant
challenge
to
global
healthcare,
particularly
with
increasing
antifungal
resistance
limiting
treatment
efficacy.
Early
detection
and
timely
intervention
remain
critical,
yet
pathogens
employ
diverse
mechanisms
evade
host
immunity
develop
resistance,
undermining
existing
therapeutic
options.
Limited
options
necessitate
novel
strategies.
This
review
provides
comprehensive
overview
conventional
agents,
their
action,
emerging
pathways.
Furthermore,
it
highlights
recently
approved
investigational
compounds
while
evaluating
innovative
approaches
such
as
nanotechnology,
drug
repurposing,
immunotherapy.
Addressing
requires
multifaceted
strategy
that
integrates
therapeutics,
enhanced
diagnostic
tools,
future
research
efforts
sustainable
effective
solutions.
Язык: Английский
Novel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application
Wallace Cordeiro de Morais,
G. Costa,
Vinícius Leal Pitcella
и другие.
Journal of Fungi,
Год журнала:
2025,
Номер
11(1), С. 69 - 69
Опубликована: Янв. 16, 2025
Fungal
infections
have
become
a
growing
concern
in
healthcare,
particularly
immunocompromised
individuals,
with
species
like
Candida,
Cryptococcus,
and
Sporothrix
posing
significant
challenges
due
to
rising
resistance
limited
treatment
options.
In
response,
novel
antifungal
agents
are
being
explored,
including
thiazolyl
hydrazones.
This
study
focuses
on
the
development
of
thiazolylhydrazone
derivative,
RW3.
RW3
was
synthesized
improve
its
water
solubility
pharmacokinetic
properties.
The
compound
demonstrated
broad
spectrum,
effective
against
Cryptococcus
neoformans
Candida
auris,
minimal
irritant
potential
low
cytotoxicity.
showed
favorable
high
intestinal
permeability,
indicating
for
oral
administration.
results
suggest
as
promising
lead
further
therapeutic
agent
systemic
fungal
infections.
These
findings
underscore
importance
optimizing
drug
properties
enhance
efficacy
safety
profiles,
opening
path
innovative
treatments.
Язык: Английский
Rutin attenuates oxidative damage-induced renal injury in rats experimentally infected with Cryptococcus neoformans by improving antioxidant capacity and reducing fungal burden
Microbial Pathogenesis,
Год журнала:
2025,
Номер
unknown, С. 107540 - 107540
Опубликована: Апрель 1, 2025
Язык: Английский
Mycobiota and Antifungal Antibodies as Emerging Targets for the Diagnosis and Prognosis of Human Diseases
Journal of Fungi,
Год журнала:
2025,
Номер
11(4), С. 296 - 296
Опубликована: Апрель 9, 2025
The
human
body
is
colonized
by
diverse
microorganisms,
with
bacteria
being
the
most
extensively
studied.
However,
fungi,
collectively
known
as
"the
mycobiota,"
are
increasingly
recognized
integral
components
of
microbiota,
inhabiting
nearly
all
mucosal
surfaces.
Commensal
fungi
influence
host
immunity
similarly
to
and
contribute
other
essential
functions,
including
metabolism.
This
emerging
understanding
positions
potential
biomarkers
for
diagnosis
prognosis
various
diseases.
In
this
review,
we
explore
dual
roles
both
commensals
pathogens,
antifungal
antibodies
serve
diagnostic
prognostic
tools,
especially
in
chronic
immune-inflammatory
non-communicable
diseases,
inflammatory
bowel
disease,
rheumatoid
arthritis,
multiple
sclerosis,
neurodegenerative
disorders.
Finally,
address
current
challenges
outline
future
perspectives
leveraging
fungal
clinical
practice.
Язык: Английский
Uncovering the role of mitochondrial genome in pathogenicity and drug resistance in pathogenic fungi
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 16, 2025
Fungal
infections
are
becoming
more
prevalent
globally,
particularly
affecting
immunocompromised
populations,
such
as
people
living
with
HIV,
organ
transplant
recipients
and
those
on
immunomodulatory
therapy.
Globally,
approximately
6.55
million
affected
by
invasive
fungal
annually,
leading
to
serious
health
consequences
death.
Mitochondria
membrane-bound
organelles
found
in
almost
all
eukaryotic
cells
play
an
important
role
cellular
metabolism
energy
production,
including
pathogenic
fungi.
These
possess
their
own
genome,
the
mitochondrial
which
is
usually
circular
encodes
proteins
essential
for
production.
Variation
evolutionary
adaptation
within
between
species'
genomes
can
affect
function,
consequently
production
metabolic
activity,
may
contribute
pathogenicity
drug
resistance
certain
species.
This
review
explores
link
genome
mechanisms
of
resistance,
a
particular
focus
Cryptococcus
neoformans
Candida
albicans.
insights
deepen
our
understanding
biology
provide
new
avenues
developing
innovative
therapeutic
strategies.
Язык: Английский
Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review
Children,
Год журнала:
2024,
Номер
11(7), С. 871 - 871
Опубликована: Июль 18, 2024
Antibiotic,
analgesic
sedative,
and
antiseizure
medications
are
among
the
most
commonly
used
in
preterm/sick
neonates,
who
at
high
risk
of
nosocomial
infections,
central
nervous
system
complications,
exposed
to
numerous
painful/stressful
procedures.
These
severe
potentially
life-threatening
complications
may
have
serious
short-
long-term
consequences
should
be
prevented
and/or
promptly
treated.
The
reported
variability
neonates
indicates
lack
adequate
neonatal
studies
regarding
their
effectiveness
safety.
Important
obstacles
contributing
inadequate
infants
include
difficulties
obtaining
parental
consent,
physicians’
unwillingness
recruit
preterm
infants,
off-label
use
many
other
scientific
ethical
concerns.
This
review
is
an
update
on
antimicrobials
(antifungals),
analgesics
(sedatives),
focusing
current
evidence
or
knowledge
gaps
pharmacokinetics,
indications,
safety,
dosage,
evidence-based
guidelines
for
optimal
neonates.
We
also
address
effects
early
antibiotic
intestinal
microbiome
its
association
with
immune-related
diseases,
obesity,
neurodevelopment
(ND).
Recommendations
empirical
treatment
emergence
pathogen
resistance
antifungals
presented.
Finally,
future
perspectives
prevention,
modification,
reversal
discussed.
Язык: Английский