Embracing a Penta helix hub framework for co-creating sustaining and potentially disruptive sterilization innovation that enables artificial intelligence and sustainability: A scoping review

The Science of The Total Environment, Год журнала: 2025, Номер 972, С. 179018 - 179018

Опубликована: Март 14, 2025

Язык: Английский

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Neonatal Infectious Disease: A Major Contributor to Infant Mortality Requiring Advances in Point-of-Care Diagnosis

Antibiotics, Год журнала: 2024, Номер 13(9), С. 877 - 877

Опубликована: Сен. 13, 2024

Neonatal infectious disease continues to result in high rates of infant morbidity and mortality. Early- late-onset represent difficult detect treat illnesses, particularly when antimicrobial resistant pathogens are present. Newborns immunodeficient at increased risk vertical horizontal infection, with preterm infants increasingly susceptible. Additional factors associated infection include prolonged use a central catheter and/or ventilation, congenital abnormalities, admittance intensive care units, the broad-spectrum antibiotics. There is increasing recognition importance host microbiome dysbiosis on neonatal disease, including necrotising enterocolitis sepsis patients. Current diagnostic methods rely blood culture, which unreliable, time consuming, can false negatives. lack accurate reliable tools available for early detection infants; therefore, efficient triage treatment remains challenging. The application biomarkers, machine learning, artificial intelligence, biosensors, microfluidics technology, may offer improved methodologies. Point-of-care devices, such methodologies, provide fast, reliable, aids This review will discuss as impacted by resistance highlight novel point-of-care options.

Язык: Английский

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Maternal Infections, Antibiotics, Steroid Use, and Diabetes Mellitus Increase Risk of Early-Onset Sepsis in Preterm Neonates: A Nationwide Population-Based Study

Pathogens, Год журнала: 2025, Номер 14(1), С. 89 - 89

Опубликована: Янв. 17, 2025

The global evolution of pathogens causing early-onset sepsis (EOS), a critical condition in preterm infants, necessitates re-evaluation risk factors to develop updated prevention and treatment strategies. This nationwide case–control study Taiwan analyzed data from the National Health Insurance Research Database, Birth Reporting Maternal Child Database 2010 2019. included 176,681 mother–child pairs with births. We identified 2942 clinical EOS cases 5535 diagnosed cases, excluding unlikely cases. A control group 14,710 neonates without was selected at 1:5 ratio. Clinical increased since 2017. Adjusted logistic regression significant including maternal fever, chorioamnionitis, diabetes mellitus, antibiotic usage, very birth, birth weight (all p < 0.001), pneumonia (p = 0.002), CS 0.004). Effective conditions like diabetes, infections is essential prevent infants. Key measures include reducing unnecessary antibiotics or steroids, minimizing cesarean sections, avoiding premature prolonged rupture membranes (PPROM), increasing gestational age neonatal weight. High-risk should be closely monitored for considered when warranted.

Язык: Английский

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Bioinspired programmed antibiofilm strategies for accelerated wound healing via spatiotemporally controlled enzyme nanoreactors

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113582 - 113582

Опубликована: Март 1, 2025

Язык: Английский

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Association of mean corpuscular volume with 28-day mortality in sepsis patients: A retrospective cohort study using eICU data

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0321213 - e0321213

Опубликована: Апрель 21, 2025

Introduction The issue of mortality due to sepsis remains a significant concern in the field medicine. Previous researches have demonstrated an association between mean corpuscular volume (MCV) and from range diseases. objective this study was investigate relationship MCV risk large multicentre cohort. Method A retrospective cohort conducted using data eICU Collaborative Research Database 2014–2015. determined within initial 24 hours ICU admission, with patients subsequently classified into quartiles based on their levels. Multivariate regression models were employed correlation 28-day mortality, adjustments made for potential confounding factors such as age, sex, body mass index, vital signs comorbidities. To evaluate dose-response sepsis, smoothed curve fitting threshold effects analysis utilised. Results total 9,415 included rate 9.38% (883/9415). After adjusting variables, it found that odds ratio (OR) 1.11 (95% CI 1.01, 1.23, P=0.04) increased followed by each 1 fl increase MCV. fitted curves nonlinear positive mortality. inflection point level 83 fl. At <83 fl, there (OR 1.10, 95% 1.02, 1.17, P =0.004). Conclusions There is non-linear death sepsis. Clinicians should be aware changes indicator, especially high

Язык: Английский

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Lily extract ameliorate mouse pneumonia by modulating ciliary function

Journal of Functional Foods, Год журнала: 2024, Номер 123, С. 106603 - 106603

Опубликована: Ноя. 29, 2024

Язык: Английский

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