Isolation, Characterization, and Genomic Analysis of Three Novel E. coli Bacteriophages That Effectively Infect E. coli O18 DOI Creative Commons
Fatma Abdelrahman, Nouran Rezk,

Mohamed S. Fayez

и другие.

Microorganisms, Год журнала: 2022, Номер 10(3), С. 589 - 589

Опубликована: Март 9, 2022

Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian E. (APEC) causes severe systemic disease in poultry (Colibacillosis), and accordingly, has an extreme risk to industry public health Due increased rate multi-drug resistance among these bacteria, it necessary find alternative therapy antibiotics treat such infections. Bacteriophages are considered best solutions. This study aimed isolate, characterize, evaluate potential use isolated bacteriophages control infections poultry. Three novel phages against O18 were from sewage water characterized vitro. The genome size three was estimated be 44,776 bp, electron microscopic analysis showed that they belonged Siphoviridae family, order Caudovirales. Phages good tolerance a broad range pH temperature. complete genomes sequenced deposited into GenBank database. closely related published identified using BLASTn alignment phylogenetic trees. prediction open reading frames (ORFs) protein-coding genes responsible for functions have been assigned as cell lysis proteins, DNA packaging structural replication/transcription/repair proteins.

Язык: Английский

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events DOI Creative Commons
Tiago Lima, Sara Domingues, Gabriela Silva

и другие.

Veterinary Sciences, Год журнала: 2020, Номер 7(3), С. 110 - 110

Опубликована: Авг. 13, 2020

The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, resistance genes (ARGs) antibiotic-resistant bacteria are frequently detected manure-amended soils. This review explores role persistence dissemination ARGs environment, analyzes procedures decrease antimicrobial potential impact application public health. We highlight that shows unique features a hotspot gene by horizontal transfer events: richness nutrients, high abundance diversity populations residues may exert selective pressure on trigger mobilization; reduction methodologies able reduce concentrations some, but not all, antimicrobials microorganisms. Conjugation events often seen even after composting. Antibiotic considered growing threat human, animal environmental Therefore, it crucial amount load resistant end up soil.

Язык: Английский

Процитировано

166

Bacteriophage-based advanced bacterial detection: Concept, mechanisms, and applications DOI

Wajid Hussain,

Muhammad Wajid Ullah, Umer Farooq

и другие.

Biosensors and Bioelectronics, Год журнала: 2021, Номер 177, С. 112973 - 112973

Опубликована: Янв. 9, 2021

Язык: Английский

Процитировано

117

Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review DOI Creative Commons
Siyu Liu,

Hongyun Lu,

Shengliang Zhang

и другие.

Pharmaceutics, Год журнала: 2022, Номер 14(2), С. 427 - 427

Опубликована: Фев. 16, 2022

Bacterial biofilms formed by pathogens are known to be hundreds of times more resistant antimicrobial agents than planktonic cells, making it extremely difficult cure biofilm-based infections despite the use antibiotics, which poses a serious threat human health. Therefore, there is an urgent need develop promising alternative therapies reduce burden drug-resistant bacterial caused biofilms. As natural enemies bacteria, bacteriophages (phages) have advantages high specificity, safety and non-toxicity, possess great potential in defense removal pathogenic biofilms, considered alternatives treat diseases. This work mainly reviews composition, structure formation process briefly discusses interaction between phages summarizes several strategies based on their derivatives against serving purpose developing novel, safe effective treatment methods promoting application maintaining

Язык: Английский

Процитировано

110

Advanced strategies for mitigation of membrane fouling in anaerobic membrane bioreactors for sustainable wastewater treatment DOI

Sojin Min,

Hosung Lee, Lijuan Deng

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149996 - 149996

Опубликована: Фев. 28, 2024

Язык: Английский

Процитировано

24

Engineering bacteriophages for targeted superbug eradication DOI
Ghazal Ghaznavi,

Parisa Vosough,

Abdolmajid Ghasemian

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

2

Therapeutic modulation of fish gut microbiota, a feasible strategy for aquaculture? DOI
Francisco Vargas‐Albores, Luis Rafael Martínez‐Córdova, Adrián Hernández‐Mendoza

и другие.

Aquaculture, Год журнала: 2021, Номер 544, С. 737050 - 737050

Опубликована: Июнь 15, 2021

Язык: Английский

Процитировано

103

Physics of viral dynamics DOI Open Access
Robijn Bruinsma, Gijs J. L. Wuite, Wouter H. Roos

и другие.

Nature Reviews Physics, Год журнала: 2021, Номер 3(2), С. 76 - 91

Опубликована: Янв. 12, 2021

Язык: Английский

Процитировано

93

Microbiome therapeutics: exploring the present scenario and challenges DOI Creative Commons
Monika Yadav, Nar Singh Chauhan

Gastroenterology report, Год журнала: 2021, Номер 10

Опубликована: Ноя. 10, 2021

Human gut-microbiome explorations have enriched our understanding of microbial colonization, maturation, and dysbiosis in health-and-disease subsets. The enormous metabolic potential gut microbes their role the maintenance human health is emerging, with new avenues to use them as therapeutic agents overcome disorders. Microbiome therapeutics are aimed at engineering microbiome using additive, subtractive, or modulatory therapy an application native engineered microbes, antibiotics, bacteriophages, bacteriocins. This approach could limitation conventional by providing personalized, harmonized, reliable, sustainable treatment. Its huge economic has been shown global market. Despite economical potential, still developing stage facing various technical administrative issues that require research attention. review aims address current knowledge landscape therapeutics, provides overview existing applications, discusses future directions modulations.

Язык: Английский

Процитировано

85

Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents DOI Creative Commons
Stephen Amankwah,

Kedir Abdella Abdusemed,

Tesfaye Kassa

и другие.

Nanotechnology Science and Applications, Год журнала: 2021, Номер Volume 14, С. 161 - 177

Опубликована: Сен. 1, 2021

Abstract: Biofilms are bacterial communities that live in association with biotic or abiotic surfaces and enclosed an extracellular polymeric substance. Their formation on both surfaces, including human tissue medical device pose a major threat causing chronic infections. In addition, current antibiotics antiseptic agents have shown limited ability to completely remove biofilms. this review, the authors provide overview of biofilms its characteristics, burden evolution phages. Moreover, most recent possible use phages phage-derived enzymes combat bacteria biofilm structures is elucidated. From emerging results, it can be concluded despite successful products destroying biofilms, they mostly not adequate eradicate all cells. Nevertheless, combined therapy and/or other antimicrobial antibiotics, nanoparticles, peptides may effective approaches from treat their associated infections humans. Keywords: substance, phages, enzymes,

Язык: Английский

Процитировано

81

Cocultivation of an ultrasmall environmental parasitic bacterium with lytic ability against bacteria associated with wastewater foams DOI
Steven Batinovic, J. Rose, Julian Ratcliffe

и другие.

Nature Microbiology, Год журнала: 2021, Номер 6(6), С. 703 - 711

Опубликована: Апрель 29, 2021

Язык: Английский

Процитировано

62