Pharmaceutics,
Год журнала:
2024,
Номер
16(3), С. 374 - 374
Опубликована: Март 8, 2024
This
review
aims
at
presenting
the
main
strategies
that
are
currently
available
for
delivery
of
bacteriophages
to
combat
bacterial
infections
in
humans,
animals,
and
plants.
It
can
be
seen
routes
phage
topical,
oral,
systemic,
airways
humans.
In
topical
oral
most
used.
To
plant
species,
spraying
plant’s
phyllosphere
or
drenching
soil
commonly
used
methods.
both
therapy
biocontrol
using
phages,
very
promising
results
have
been
obtained
so
far.
However,
more
experiments
needed
establish
forms
treatment
doses,
among
other
parameters.
Furthermore,
general,
there
is
a
lack
specific
standards
use
phages
infections.
Veterinary Sciences,
Год журнала:
2020,
Номер
7(3), С. 110 - 110
Опубликована: Авг. 13, 2020
The
increasing
demand
for
animal-derived
foods
has
led
to
intensive
and
large-scale
livestock
production
with
the
consequent
formation
of
large
amounts
manure.
Livestock
manure
is
widely
used
in
agricultural
practices
as
soil
fertilizer
worldwide.
However,
several
antibiotic
residues,
resistance
genes
(ARGs)
antibiotic-resistant
bacteria
are
frequently
detected
manure-amended
soils.
This
review
explores
role
persistence
dissemination
ARGs
environment,
analyzes
procedures
decrease
antimicrobial
potential
impact
application
public
health.
We
highlight
that
shows
unique
features
a
hotspot
gene
by
horizontal
transfer
events:
richness
nutrients,
high
abundance
diversity
populations
residues
may
exert
selective
pressure
on
trigger
mobilization;
reduction
methodologies
able
reduce
concentrations
some,
but
not
all,
antimicrobials
microorganisms.
Conjugation
events
often
seen
even
after
composting.
Antibiotic
considered
growing
threat
human,
animal
environmental
Therefore,
it
crucial
amount
load
resistant
end
up
soil.
Pharmaceutics,
Год журнала:
2022,
Номер
14(2), С. 427 - 427
Опубликована: Фев. 16, 2022
Bacterial
biofilms
formed
by
pathogens
are
known
to
be
hundreds
of
times
more
resistant
antimicrobial
agents
than
planktonic
cells,
making
it
extremely
difficult
cure
biofilm-based
infections
despite
the
use
antibiotics,
which
poses
a
serious
threat
human
health.
Therefore,
there
is
an
urgent
need
develop
promising
alternative
therapies
reduce
burden
drug-resistant
bacterial
caused
biofilms.
As
natural
enemies
bacteria,
bacteriophages
(phages)
have
advantages
high
specificity,
safety
and
non-toxicity,
possess
great
potential
in
defense
removal
pathogenic
biofilms,
considered
alternatives
treat
diseases.
This
work
mainly
reviews
composition,
structure
formation
process
briefly
discusses
interaction
between
phages
summarizes
several
strategies
based
on
their
derivatives
against
serving
purpose
developing
novel,
safe
effective
treatment
methods
promoting
application
maintaining
Gastroenterology report,
Год журнала:
2021,
Номер
10
Опубликована: Ноя. 10, 2021
Human
gut-microbiome
explorations
have
enriched
our
understanding
of
microbial
colonization,
maturation,
and
dysbiosis
in
health-and-disease
subsets.
The
enormous
metabolic
potential
gut
microbes
their
role
the
maintenance
human
health
is
emerging,
with
new
avenues
to
use
them
as
therapeutic
agents
overcome
disorders.
Microbiome
therapeutics
are
aimed
at
engineering
microbiome
using
additive,
subtractive,
or
modulatory
therapy
an
application
native
engineered
microbes,
antibiotics,
bacteriophages,
bacteriocins.
This
approach
could
limitation
conventional
by
providing
personalized,
harmonized,
reliable,
sustainable
treatment.
Its
huge
economic
has
been
shown
global
market.
Despite
economical
potential,
still
developing
stage
facing
various
technical
administrative
issues
that
require
research
attention.
review
aims
address
current
knowledge
landscape
therapeutics,
provides
overview
existing
applications,
discusses
future
directions
modulations.
Nanotechnology Science and Applications,
Год журнала:
2021,
Номер
Volume 14, С. 161 - 177
Опубликована: Сен. 1, 2021
Abstract:
Biofilms
are
bacterial
communities
that
live
in
association
with
biotic
or
abiotic
surfaces
and
enclosed
an
extracellular
polymeric
substance.
Their
formation
on
both
surfaces,
including
human
tissue
medical
device
pose
a
major
threat
causing
chronic
infections.
In
addition,
current
antibiotics
antiseptic
agents
have
shown
limited
ability
to
completely
remove
biofilms.
this
review,
the
authors
provide
overview
of
biofilms
its
characteristics,
burden
evolution
phages.
Moreover,
most
recent
possible
use
phages
phage-derived
enzymes
combat
bacteria
biofilm
structures
is
elucidated.
From
emerging
results,
it
can
be
concluded
despite
successful
products
destroying
biofilms,
they
mostly
not
adequate
eradicate
all
cells.
Nevertheless,
combined
therapy
and/or
other
antimicrobial
antibiotics,
nanoparticles,
peptides
may
effective
approaches
from
treat
their
associated
infections
humans.
Keywords:
substance,
phages,
enzymes,
Microorganisms,
Год журнала:
2021,
Номер
9(2), С. 261 - 261
Опубликована: Янв. 27, 2021
Bacteriophages
are
viruses
that
exclusively
kill
bacteria
and
the
most
ubiquitous
organisms
on
planet.
Since
their
discovery,
bacteriophages
have
been
considered
an
important
weapon
to
fight
human
animal
infections
of
bacterial
origin
due
specific
ability
attack
associated
target
bacteria.
With
discovery
antibiotics,
phage
treatment
was
progressively
abandoned
in
Western
countries.
However,
recent
emergence
growing
antimicrobial
resistance
(AMR)
interest
use
therapy
has
once
again
grown.
Similarly,
at
environmental
level,
extensive
disinfectants
based
chemicals,
including
biocides
agriculture,
with
against
themselves,
besides
having
a
high
impact.
Due
these
issues,
applications
phages
biocontrol
purposes
become
interesting
option
several
fields,
farms,
food
industry,
aquaculture
wastewater
plants.
Notably,
action
is
maintained
even
when
multidrug
resistant
(MDR),
rendering
this
extremely
counteracting
AMR
both
for
therapeutical
decontamination
purposes.
Based
this,
interestingly
proposed
as
routine
sanitizers
hospitals,
counteract
spread
pathogenic
MDR
persistently
contaminate
hard
surfaces.
This
review
summarizes
studies
aimed
evaluating
potential
decontaminants,
special
focus
hospital
sanitation.
