Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 21, 2023
Abstract
Microbial
transglutaminase
(mTG)
is
a
bacterial
survival
factor,
frequently
used
as
food
additive
to
glue
processed
nutrients.
As
result,
new
immunogenic
epitopes
are
generated
that
might
drive
autoimmunity.
Presently,
its
contribution
autoimmunity
through
epitope
similarity
and
cross-reactivity
was
investigated.
Emboss
Matcher
perform
sequence
alignment
between
mTG
various
antigens
implicated
in
many
autoimmune
diseases.
Monoclonal
polyclonal
antibodies
made
specifically
against
were
applied
77
different
human
tissue
using
ELISA.
Six
detected
share
significant
homology
with
sequences,
representing
major
targets
of
common
conditions.
Polyclonal
antibody
reacted
significantly
17
out
antigens.
This
reaction
most
pronounced
mitochondrial
M2,
ANA,
extractable
nuclear
The
results
indicate
possible,
supporting
the
relationship
development
disorders.
150W
Long
COVID-19
affects
a
significant
percentage
of
survivors
and
is
characterized
by
wide
range
symptoms,
including
weariness
mental
fog
as
well
emotional
symptoms
like
worry
sadness.
closely
linked
to
the
autoimmune
disorders
that
are
becoming
more
prevalent
worldwide
immune
system
hyperactivation,
neutrophil
extracellular
trap
(NET)
development,
molecular
mimicry
pathways.
Long-term
COVID-related
responses
include
watchful
system,
altered
innate
adaptive
cells,
autoantigens
secreted
living
or
dead
neutrophils,
high
concentrations
autoantibodies
directed
against
different
proteins.
The
microbiome,
which
consists
billions
bacteria
in
human
body,
essential
for
controlling
supporting
overall
health.
microbiome
can
affect
course
long-term
COVID-associated
autoimmunity,
degree
illness,
rate
recovery,
onset
reactions.
Although
precise
role
long
COVID
autoimmunity
still
being
investigated,
new
studies
indicate
probiotics,
prebiotics,
dietary
changes—interventions
target
microbiome—may
be
able
reduce
reactions
enhance
outcomes
survivors.
It
clear
research
required
precisely
understand
how
COVID-19-related
create
tailored
treatment
plans.
International Journal of Medical Science and Dental Health,
Год журнала:
2024,
Номер
10(02), С. 99 - 115
Опубликована: Фев. 22, 2024
Cytokines
highly
contribute
into
the
process
of
Mediated
immune
responses
and
its
role
is
evident
with
discovery
cytokines
as
key
biomarkers
in
healthcare
field.
It
examines
current
cytokine
assay
conditions,
which
are
critical
for
diagnosis,
prognosis
treatment
monitoring.
The
review
must
include
problems
standardization,
variability,
clinical
implementation.,
but
will
demonstrate
probability
personalized
medicine,
therapeutic
gains
well.
Future
directions
studies
expected
to
capitalize
on
recently
emerged
technological
applications,
network-based
determinations,
precision
medicine-oriented
approaches
that
be
employed
aid
patients
enhance
diseases.
Arthritis Care & Research,
Год журнала:
2024,
Номер
77(1), С. 3 - 11
Опубликована: Сен. 4, 2024
A
critical
unanswered
question
is
what
causing
the
increase
in
prevalence
of
autoimmunity
and
autoimmune
diseases
around
world.
Given
rapidity
change,
this
likely
result
major
recent
alterations
our
exposures
to
environmental
risk
factors
for
these
diseases.
More
evidence
becoming
available
that
evolution
disease,
years
or
even
decades
making,
results
from
multiple
alter
susceptible
genomes
immune
systems
over
time.
Exposures
during
sensitive
phases
key
developmental
hormonal
periods
may
set
stage
effects
later
exposures.
It
synergistic
additive
impacts
exposure
mixtures
chronic
low‐level
inflammation.
This
inflammation
eventually
pass
thresholds
lead
system
activation
autoimmunity,
with
further
molecular
pathologic
changes,
complete
clinical
syndrome
emerges.
Much
work
remains
be
done
define
mechanisms
protective
conditions.
However,
points
a
variety
pollutants,
xenobiotics,
infections,
occupational
exposures,
medications,
smoking,
psychosocial
stressors,
changes
diet,
obesity,
exercise,
sleep
patterns,
as
well
climate
change
increased
heat,
storms,
floods,
wildfires,
droughts,
UV
radiation,
malnutrition,
changing
possible
contributors.
Substantial
investments
defining
role
causal
factors,
whom
when
their
are
most
important,
necessary
sufficient
gene‐environment
interactions,
improved
diagnostics
therapies,
preventive
strategies
needed
now
limit
many
negative
personal,
societal,
financial
will
otherwise
occur.
Central European Journal of Immunology,
Год журнала:
2023,
Номер
48(4), С. 322 - 329
Опубликована: Янв. 1, 2023
AMA
Vanaga
I,
Kolesova
O,
Kolesovs
A,
et
al.
Association
of
human
leukocyte
antigen
class
II
alleles
with
epithelial
cell
apoptosis
and
extracellular
matrix
production
in
acute
COVID-19.
Central
European
Journal
Immunology.
2023.
doi:10.5114/ceji.2023.133684.
APA
Vanaga,
I.,
Kolesova,
O.,
Kolesovs,
A.,
Sture,
G.,
Hagina,
E.,
&
Storozenko,
J.
(2023).
https://doi.org/10.5114/ceji.2023.133684
Chicago
Ieva,
Oksana
Aleksandrs
Gunta
Elvira
Jelena
Liene
Nikitina-Zake
"Association
COVID-19".
Harvard
J.,
Nikitina-Zake,
L.,
Viksna,
L.
MLA
Ieva
COVID-19."
Immunology,
Vancouver
Sture
G,
Hagina
E,
Storozenko
J
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 21, 2023
Abstract
Microbial
transglutaminase
(mTG)
is
a
bacterial
survival
factor,
frequently
used
as
food
additive
to
glue
processed
nutrients.
As
result,
new
immunogenic
epitopes
are
generated
that
might
drive
autoimmunity.
Presently,
its
contribution
autoimmunity
through
epitope
similarity
and
cross-reactivity
was
investigated.
Emboss
Matcher
perform
sequence
alignment
between
mTG
various
antigens
implicated
in
many
autoimmune
diseases.
Monoclonal
polyclonal
antibodies
made
specifically
against
were
applied
77
different
human
tissue
using
ELISA.
Six
detected
share
significant
homology
with
sequences,
representing
major
targets
of
common
conditions.
Polyclonal
antibody
reacted
significantly
17
out
antigens.
This
reaction
most
pronounced
mitochondrial
M2,
ANA,
extractable
nuclear
The
results
indicate
possible,
supporting
the
relationship
development
disorders.
150W
