Assay and Drug Development Technologies,
Год журнала:
2023,
Номер
22(1), С. 1 - 17
Опубликована: Дек. 29, 2023
The
objective
of
this
study
was
to
develop
and
evaluate
a
novel
vesicular
formulation
luliconazole
(LUL)
for
the
management
Candida
albicans
infection
through
topical
route.
LUL-loaded
transethosomes
(LUL-TE)
were
prepared
by
film
hydration
method
various
independent
dependent
variables
optimized
using
Box–Behnken
design.
Selected
critical
material
attributes
content
phospholipids
(X1),
concentration
ethanol
(X2),
amount
sodium
cholate
(X3).
Formulated
LUL-TE
characterized
percent
entrapment
efficiency,
drug
loading,
vesicle
size,
polydispersity
index
(PDI)
incorporated
into
carbomer
gel
base
further
evaluated
characterizations.
transethosomal
(LUL-TE-CHG)
pH,
spreadability,
viscosity,
antifungal
activity,
in
vitro
study.
From
observed
results,
it
evident
that
LUL-TE-CHG
desired
pH
(6.2
±
0.45),
spreadability
[8.3
0.42
g/(cm·s)],
viscosity
(236.1–19.2.26
mPa·s),
nanovesicle
size
(252
9.82),
efficiency
(85%
5.24%),
zeta
potential
(−34.05
3.52
mV),
PDI
(0.233
0.002).
zone
inhibition
results
suggested
has
highest
is,
5.83
0.15
mm3.
showed
release
within
2
h
18.1%
2.0%
after
sustained
action,
83.2%
1.7%
8
h.
Finally,
confirm
therapeutic
efficacy
developed
formulation,
fungal
induced
C.
Wistar
rats.
In
vivo,
skin
irritation
histopathology
studies
performed
disease-induced
model.
Animal
experiments
revealed
significantly
improved
diseased
condition
from
permeation
deposition
profile
ensure
TE
system
had
higher
rate
increased
retention
time
compared
with
LUL-CHG.
hydrogel
LUL
could
be
approach
safe
effective
treatment.
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1181 - 1181
Опубликована: Март 6, 2025
Nano-drug
delivery
systems
provide
targeted
solutions
for
addressing
various
drug
challenges,
leveraging
nanotechnology
to
enhance
solubility
and
permeability.
Liposomes,
explored
several
decades,
face
hurdles,
especially
in
oral
delivery.
Bile-acid
stabilized
vesicles
(bilosomes)
are
flexible
lipid
vesicles,
composed
of
phospholipids
or
other
surfactants,
along
with
amphiphilic
bile
salts,
they
show
superior
stability
pharmacokinetic
behavior
comparison
conventional
vesicular
(liposomes
niosomes).
Bilosomes
skin
penetration,
fluidize
the
stratum
corneum,
improve
stability.
In
applications,
bilosomes
overcome
drawbacks,
offering
improved
bioavailability,
controlled
release,
reduced
side
effects.
Vaccines
using
demonstrate
efficacy,
intranasal,
inhalation,
ocular,
buccal
applications
delivery,
targeted,
efficient,
activities.
Formulations
vary
based
on
active
substances
optimization
techniques,
showcasing
versatility
potential
across
diverse
routes.
Therefore,
aim
this
comprehensive
review
was
critically
explore
state-of-the-art
therapeutic
applications.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 697 - 697
Опубликована: Май 23, 2024
In
recent
years,
there
has
been
a
notable
surge
in
the
utilization
of
stabilized
bile
acid
liposomes,
chemical
conjugates,
complexes,
mixed
micelles,
and
other
drug
delivery
systems
derived
from
acids,
often
referred
to
as
bilosomes.
The
molecular
structure
interactions
these
amphiphilic
compounds
provide
distinctive
captivating
subject
for
investigation.
enhanced
stability
new
generation
bilosomes
inside
gastrointestinal
system
results
prevention
degradation
an
improvement
mucosal
penetration.
These
characteristics
render
be
prospective
nanocarrier
pharmaceutical
administration,
prompting
researchers
investigate
their
potential
domains.
This
review
paper
discusses
that
have
emerged
viable
modality
realm
significant
promise
use
across
several
Moreover,
this
underscores
need
additional
investigation
advancement
order
comprehensively
comprehend
uses
effectiveness
field
administration.
study
explores
current
scholarly
attention
on
carriers
delivery.
Therapeutic
areas
where
shown
outstanding
performance
terms
are
outlined
graphical
abstract.
Abstract
Background
Oral
thrush
is
the
most
common
occurring
fungal
infection
in
oral
cavity
uncontrolled
diabetic
patients,
it
treated
by
various
antifungal
drugs
according
to
each
case.
This
study
aimed
evaluate
therapeutic
effects
of
topical
application
miconazole
and
miconazole-loaded
chitosan
nanoparticles
treatment
patients
with
candidiasis.
Methods
In
this
randomized
controlled
clinical
trial.
A
total
80
presenting
symptomatic
candidiasis
were
randomly
assigned
into
two
groups:
nanoparticles.
The
for
28
days,
assessments
conducted
at
baseline,
7,
14,
21
days.
Clinical
parameters,
including
signs
symptoms
evaluated
microbiological
analysis
was
performed
determine
Candida
species
assess
their
susceptibility
agents.
Statistical
done
categorical
numerical
data
using
chi-square
test
Kruskal
Wallis
test.
Results
efficacy
between
(CS-MCZ)
groups
insignificant
difference
(
P
>
0.05)
observed.
Both
modalities
exhibited
comparable
effectiveness
controlling
reducing
colonization
as
group
showed
a
significant
improvement
respect
both
from
baseline
(70%)
until
end
days
(5%)
<
Moreover,
nanoparticles,
there
reduction
number
colonies
forming
units
albicans
28-day
value
0.000.
Conclusions
trial
demonstrate
that
are
effective
no
adverse
reactions.
Trial
registration
NCT06072716
first
10/10/2023.
ACS Omega,
Год журнала:
2023,
Номер
8(35), С. 31575 - 31599
Опубликована: Авг. 22, 2023
The
most
prevalent
infection
in
the
world
is
dermatophytosis,
which
a
major
issue
with
high
recurrence
and
can
affect
entire
body
including
skin,
hair,
nails.
goal
of
this
Review
to
acquire
knowledge
about
cutting-edge
approaches
for
treating
dermatophytosis
efficiently
by
adding
antifungals
formulations
based
on
nanocarriers
order
overcome
shortcomings
standard
treatment
methods.
Updates
nanosystems
research
developments
animal
clinical
investigations
are
also
presented.
Along
currently
licensed
formulations,
investigation
emphasizes
novel
therapies
existing
therapeutic
alternatives
that
be
used
control
dermatophytosis.
summarizes
recent
prevalence,
management
approaches,
disadvantages
dosage
types.
There
number
strategies
have
good
cure
rates
but
drawbacks
such
as
antifungal
drug
resistance
unfavorable
side
effects.
To
improve
activity
get
around
traditional
therapy
efforts
been
described
years
combine
several
drugs
into
new
carriers.
These
successful
providing
improved
activity,
longer
retention,
effectiveness,
higher
skin
penetration,
sustained
release.
Gels,
Год журнала:
2023,
Номер
9(10), С. 791 - 791
Опубликована: Окт. 1, 2023
In
this
study,
hesperidin
was
loaded
into
a
transethosome
and
developed
employing
the
rotary
evaporator
method.
The
formulation
optimized
using
Box–Behnken
design
(BBD).
HSD-TE
has
spherical
shape,
vesicle
size,
polydispersity
index,
entrapment
efficiency,
zeta
potential
within
range
of
178.98
nm;
PDI
0.259
with
−31.14
mV
%
EE
89.51%,
respectively.
in
vitro
drug
release
shows
that
exhibited
81.124
±
3.45%
comparison
to
HSD
suspension.
ex
vivo
skin
permeation
showed
2-fold
increase
gel
permeation.
antioxidant
activity
found
be
79.20
1.77%
higher
than
solution.
deeper
penetration
across
excised
rat
membranes
confocal
laser
microscopy
scanning,
indicating
promising
prospects.
dermatokinetic
compared
conventional
where
TE
significantly
boosted
transport
epidermis
dermal
layers.
greater
efficacy
free
inhibition
microbial
growth,
as
evidenced
by
antibacterial
on
Gram-negative
positive
bacteria.
These
investigations
could
enhance
topical
application
management
cutaneous
bacterial
infections.
Abstract
This
review
paper
highlights
the
trans-dermic
delivery
of
nanoparticles
(NPs)
based
antifungal
ointments
with
help
nanotechnology.
It
also
describes
novel
trans-dermal
approach
utilizing
various
which
enables
an
efficient
to
target
site.
current
gives
overview
about
past
research
and
developments
as
well
nanoparticle-based
ointments.
presents
data
regarding
types,
causes
infection,
different
pathogens
within
their
infection
information
activity
side
effects
medicines.
Additionally,
this
focuses
on
future
aspects
topical
administration
These
can
encapsulate
multiple
drugs
a
combination
therapy
targeting
fungal
infection.
Nanoparticles
be
designed
in
such
way
that
they
specifically
cells
do
not
affect
healthy
cells.
Nanoparticle
exhibit
outstanding
potential
treat
diseases.
As
further
advancements
evolve
nanotechnology,
we
expect
more
development
formulations
shortly.
discusses
all
applications,
recent
trends,
field
shows
its
bright
prospective
upcoming
years.
Graphical
abstract
Silymarin
(SLM)
is
a
bioactive,
water-insoluble
flavonoid
reported
against
different
types
of
cancer.
In
the
present
research,
SLM
inclusion
complex
was
prepared
by
freeze-drying
method
using
cyclodextrins.
The
phase
solubility
study
performed
to
assess
stability
constant
and
complexation
efficiency.
complexes
(F1,
F2,
F3)
were
characterized
for
physicochemical
in
vitro
parameters.
Based
on
results,
selected
(F2)
converted
topical
gel.
Finally,
it
evaluated
antioxidant,
protein
denaturation,
cell
viability
assay
(B16F10;
skin
cancer
line).
results
further
confirmed
performing
molecular
docking
study.
solubilization
showed
formation
stable
with
value
548
mol
L–1
(βCD-PLX),
911
(HP
βCD-PLX),
736
(M
βCD-PLX).
A
marked
increase
release
pattern
found
from
(80.9
±
2.2–97.8
3.1%)
compared
free
(24.1
2.8%).
DSC
as
well
IR
studies
confirm
complex.
SEM
X-ray
diffraction
conversion
amorphous
form.
exhibited
high
score
both
colchicine-binding
sites
tubulin
(−6.28
kcal/mol)
complexing
agents,
viz.,
βCD
(−4.61
kcal/mol),
HP
(−5.77
M
(−5.61
kcal/mol).
antioxidant
that
activity
significantly
improved
(1.2–1.6
fold)
SLM.
outcome
displayed
concentration-dependent
lower
IC50
F2G2
(145.3
4.2
μg/mL)
than
(304.7
5.7
μg/mL).
above
conclusions
demonstrated
developed
complex-based
gel
system
could
be
an
ideal
delivery
