Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 758 - 758
Опубликована: Июнь 9, 2024
Accidental
poisonings
by
ingesting
conjunctival
fluid
mixed
with
eye
drops
commonly
involve
alpha-2
adrenergic
receptor
agonists
and
tetrahydrozoline.
These
substances
are
recognized
in
reported
ingestions.
Victims
of
all
ages,
otherwise
good
health,
often
present
as
pale
lethargic
to
the
emergency
department
(ED)
after
unintentionally
topical
medication.
While
drop
poisoning
cases
childhood
include
accidents
during
play
adults
mean
either
suicide
attempts
or
side
effects
caused
systemic
absorption
substance,
ocular
surface
is
a
risk
age
groups.
With
this
mind,
study
aimed
summarize
data
literature
on
tetrahydrozoline
dangerous
medications,
even
when
administered
low-bioavailability
forms,
such
drops.
aim,
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)-compliant
systematic
review
relevant
studies
was
conducted.
A
search
PubMed,
Scopus,
Web
Science,
EBSCOhost
yielded
nine
that
met
rigorous
inclusion
criteria.
The
primary
were
subject
meta-analysis
once
quality
appraisal
narrative
synthesis
extracted
had
been
author
hopes
information
will
provide
observations
lead
better
designs
over-the-counter
drops,
off-label
drug
usage
policies,
parental
attention.
Future Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
9(1)
Опубликована: Дек. 11, 2023
Abstract
Background
Nanoparticles
have
emerged
as
a
viable
biological
candidate
with
the
possibility
to
be
employed
drug
carriers.
They
acquire
high
surface-to-volume
ratios
and
unique
physicochemical
features
such
biochemical,
magnetic,
optical,
electrical
changes
at
cellular,
atomic,
molecular
levels.
This
phenomenon
has
proven
extensive
utility
for
biomedical
applications,
their
activity
fewer
adverse
effects
than
traditional
medications.
Main
body
of
abstract
The
new
spectrum
nanomaterials—nanomedicines—has
accomplished
disease
management
by
detecting,
restoring,
regeneration
damaged
tissues.
Therefore,
designing
appropriate
nanomaterial-based
delivery
systems
final
clinical
evaluations
requires
accurate
knowledge
pharmacokinetic
factors
relevant
LADME
in
order
meet
required
criteria
(liberation,
adsorption,
distribution,
metabolism,
elimination).
To
identify
predict
vivo
reaction
nanoparticles,
deeper
understanding
link
between
properties
nanomaterials
contact
is
necessary.
will
allow
distinguished
comparison
medicines
nanoparticles.
Short
conclusion
review
paper
attempts
analyze
basic
potential
nanoparticles
depth.
profiling
analysis
enable
us
treatment
outcome
overcome
properties,
provide
broad
overview,
deliver
remarkable
ways
advance
use
industry.
Graphical
Polymers,
Год журнала:
2025,
Номер
17(2), С. 159 - 159
Опубликована: Янв. 10, 2025
This
study
aims
to
build
an
optimal
drug
delivery
system
by
manufacturing
and
evaluating
a
hydrogel
contact
lens
using
Tretinoin
(ATRA)
protein
nanoparticles
improve
the
as
ophthalmic
medical
lens.
To
evaluate
optical
physical
properties
of
manufactured
lens,
spectral
transmittance,
refractive
index,
water
content,
angle,
AFM,
tensile
strength,
delivery,
antibacterial
were
analyzed.
The
was
contain
ATRA
bovine
serum
albumin
(BSA)
in
different
ways,
results
confirmed
that
A,
B,
C
each
had
properties.
In
particular,
for
Sample
soak
release
method
solution
with
BSA
added,
wettability
55.94°,
strength
0.1491
kgf/mm2,
released
130.35
μm
over
336
h,
which
found
be
superior
samples
B
C.
Therefore,
three
lenses
compared
this
according
addition
can
used
various
ways
is
very
useful
Biosensors,
Год журнала:
2023,
Номер
13(6), С. 663 - 663
Опубликована: Июнь 18, 2023
Biosensors
are
devices
that
quantify
biologically
significant
information
required
for
diverse
applications,
such
as
disease
diagnosis,
food
safety,
drug
discovery
and
detection
of
environmental
pollutants.
Recent
advancements
in
microfluidics,
nanotechnology
electronics
have
led
to
the
development
novel
implantable
wearable
biosensors
expedient
monitoring
diseases
diabetes,
glaucoma
cancer.
Glaucoma
is
an
ocular
which
ranks
second
leading
cause
loss
vision.
It
characterized
by
increase
intraocular
pressure
(IOP)
human
eyes,
results
irreversible
blindness.
Currently,
reduction
IOP
only
treatment
used
manage
glaucoma.
However,
success
rate
medicines
treat
quite
minimal
due
their
curbed
bioavailability
reduced
therapeutic
efficacy.
The
drugs
must
pass
through
various
barriers
reach
space,
turn
serves
a
major
challenge
treatment.
Rapid
progress
has
been
observed
nano-drug
delivery
systems
early
diagnosis
prompt
therapy
diseases.
This
review
gives
deep
insight
into
current
field
detecting
treating
glaucoma,
well
continuous
IOP.
Various
nanotechnology-based
achievements,
nanoparticle/nanofiber-based
contact
lenses
can
efficiently
monitor
efficient
also
discussed.
Intelligent Pharmacy,
Год журнала:
2024,
Номер
2(4), С. 580 - 587
Опубликована: Фев. 8, 2024
The
field
of
oral
drug
delivery
has
witnessed
significant
advancements,
with
a
focus
on
developing
innovative
formulations
to
address
challenges
associated
traditional
dosage
forms,
especially
for
patients
difficulties
in
swallowing.
Fast
Dissolving
Tablets
(FDTs)
have
emerged
as
promising
class
tablets
designed
rapidly
disintegrate
or
dissolve
saliva,
providing
convenient
and
patient-friendly
alternative
various
populations.
This
article
explores
the
unique
properties,
advantages,
potential
applications
FDTs,
emphasizing
their
role
overcoming
posed
by
conventional
systems.
FDTs
offer
rapid
dissolution
within
15-120
seconds
buccal
cavity,
facilitating
direct
absorption
through
mucosa
ensuring
quick
therapeutic
effects.
characteristic
proves
particularly
beneficial
individuals
facing
swallowing
challenges,
such
pediatric
geriatric
patients,
those
conditions
like
dysphagia.
Recognizing
significance
European
Pharmacopoeia
(EP)
officially
recognized
them
"oral
dissolving
tablets,"
highlighting
acceptance
both
academic
industrial
settings.
delves
into
anatomical
physiological
characteristics
shedding
light
epithelium,
vascularization,
salivary
flow,
which
play
crucial
roles
absorption.
ideal
features
include
disintegration,
high
load
capacity,
masking
bitter
taste,
positive
mouth
feel,
ease
transport,
reduced
sensitivity
environmental
factors.
advantages
extend
administration
unable
swallow,
treatment
bedridden
mobile
enhanced
feel
taste
masking,
administration,
precise
dosing.
Despite
come
limitations,
including
issues
related
mechanical
strength,
hygroscopic
nature,
brittleness,
drugs
unpleasant
odors.
Overcoming
these
requires
careful
formulation
approach
balance
disintegration
strength
masking.
also
discusses
salient
Dosage
Forms
(FDDDS)
techniques
preparing
freeze-drying,
tablet
molding,
spray
drying.
Additionally,
it
non-invasive
systems
addressing
pharmaceutical
industry
needs,
improving
half-life,
solubility/stability,
bioavailability.
European Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
187, С. 106494 - 106494
Опубликована: Июнь 12, 2023
Fungal
keratitis
is
an
infectious
disease
caused
by
pathogenic
fungi
with
a
high
blindness
rate.
Econazole
(ECZ)
imidazole
antifungal
drug
insoluble
ability.
Econazole-loaded
solid
lipid
nanoparticles
(E-SLNs)
were
prepared
microemulsion
method,
then
modified
positive
and
negative
charge.
The
mean
diameter
of
cationic
E-SLNs,
nearly
neutral
E-SLNs
anionic
18.73±0.14,
19.05±0.28,
18.54±0.10
nm
respectively.
Zeta
potential
these
different
charged
SLNs
formulations
19.13±0.89,
-2.20±0.10,
-27.40±0.67
mV
Polydispersity
Index
(PDI)
three
kinds
all
about
0.2.
Transmission
Electron
Microscopy
(TEM)
Differential
Scanning
Calorimetry
(DSC)
analysis
showed
that
the
homogeneous
system.
Compared
suspension
(E-Susp),
exhibited
sustained
release
capability,
stronger
corneal
penetration
enhanced
inhibition
without
irritation.
ability
was
further
improved
after
charge
modification
compared
E-SLNs.
Studies
on
pharmacokinetics
order
AUC
t1/2
preparations
>
E-Susp
in
cornea
aqueous
humor.
It
shown
could
increase
penetrability
ocular
bioavailability
while
capabilities
ones.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 457 - 457
Опубликована: Янв. 21, 2025
Ocular
diseases
affecting
the
anterior
and
posterior
segments
of
eye
are
major
causes
global
vision
impairment.
Curcumin,
a
natural
polyphenol,
exhibits
anti-inflammatory,
antioxidant,
antibacterial,
neuroprotective
properties,
making
it
promising
candidate
for
ocular
therapy.
However,
its
clinical
use
is
hindered
by
low
aqueous
solubility,
poor
bioavailability,
rapid
systemic
elimination.
This
review
comprehensively
highlights
advances
in
curcumin
delivery
systems
aimed
at
overcoming
these
challenges.
Emerging
platforms,
including
proniosomal
gels,
transferosomes,
cyclodextrin
complexes,
have
improved
permeability,
retention.
Nanoparticle-based
carriers,
such
as
hybrid
hydrogels
biodegradable
nanoparticles,
enable
sustained
release
targeted
delivery,
supporting
treatments
segment
like
diabetic
retinopathy
age-related
macular
degeneration.
For
conditions,
keratitis
dry
syndrome,
cyclodextrin-based
complexes
mucoadhesive
enhance
corneal
permeability
drug
Mechanistically,
modulates
key
pathways,
NF-κB
TLR4,
reducing
oxidative
stress,
angiogenesis,
apoptosis.
strategies
photodynamic
therapy
approaches
broaden
their
application
to
eyelid
conditions
neuroinflammatory
diseases.
These
advancements
address
curcumin’s
pharmacokinetic
limitations,
translation
into
ophthalmic
therapies.
work
underscores
potential
disease
management
advocates
trials
validate
safety,
efficacy,
therapeutic
relevance.
Journal of Ocular Pharmacology and Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Posterior
segment
ocular
diseases,
such
as
diabetic
retinopathy,
age-related
macular
degeneration,
and
retinal
vein
occlusion,
are
leading
causes
of
vision
impairment
blindness
worldwide.
Effective
management
these
conditions
remains
a
formidable
challenge
due
to
the
unique
anatomical
physiological
barriers
eye,
including
blood-retinal
barrier
rapid
drug
clearance
mechanisms.
To
address
hurdles,
nanostructured
delivery
systems
proposed
overcome
barriers,
target
retina,
enhance
permeation
while
ensuring
controlled
release.
Traditional
therapeutic
approaches,
intravitreal
injections,
pose
significant
drawbacks,
patient
discomfort,
poor
compliance,
potential
complications.
Therefore,
understanding
physiology
mechanism
eye
could
aid
in
design
novel
formulations
that
be
noninvasive
deliver
drugs
reach
site
is
pivotal
for
effective
treatment
strategies.
This
review
focuses
on
recent
advances
formulation
strategies
posterior
delivery,
highlighting
their
limitations.
Furthermore,
nanocarrier
in-situ
gel,
niosomes,
hydrogels,
dendrimers,
liposomes,
nanoparticles,
nanoemulsions
more
effectively
selectively
explored,
supplemented
with
illustrative
examples,
figures,
tables.
aims
provide
insights
into
current
state
emphasizing
need
interdisciplinary
approaches
develop
patient-centric,
minimally
invasive,
solutions.
