Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(12), С. 6062 - 6099
Опубликована: Ноя. 8, 2024
The
incidence
of
ocular
pathologies
is
constantly
increasing,
as
the
interest
researchers
in
developing
new
strategies
to
ameliorate
treatment
these
conditions.
Nowadays,
drug
delivery
systems
are
considered
among
most
relevant
approaches
due
their
applicability
a
great
variety
inner
and
outer
eye
through
painless
topical
administrations.
design
such
nanocarriers
requires
deep
study
many
aspects
related
administration
route
but
also
consideration
authorities
pharmacopeial
requirements,
order
achieve
clinical
outcome.
On
bases,
scope
this
review
describe
path
analyses
that
could
be
performed
on
nanoparticles,
along
with
assessment
for
ophthalmic
treatments.
Preformulation
studies,
physicochemical
technological
characterization,
preliminary
noncellular
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 17, 2024
Ocular
drug
delivery
presents
significant
challenges
due
to
intricate
anatomy
and
the
various
barriers
(corneal,
tear,
conjunctival,
blood-aqueous,
blood-retinal,
degradative
enzymes)
within
eye.
Lipid-based
nanoparticles
(LNPs)
have
emerged
as
promising
carriers
for
ocular
their
ability
enhance
solubility,
improve
bioavailability,
provide
sustained
release.
LNPs,
particularly
solid
lipid
(SLNs),
nanostructured
(NLCs),
cationic
(CNLCs),
solutions
enhancing
delivery.
This
review
provides
a
comprehensive
summary
of
nanoparticle-based
systems,
emphasizing
biocompatibility
efficiency
in
applications.
We
evaluated
research
articles
sourced
from
databases
such
Google
Scholar,
TandFonline,
SpringerLink,
ScienceDirect,
focusing
on
studies
published
between
2013
2023.
The
discusses
materials
methodologies
employed
preparation
SLNs,
NLCs,
CNLCs,
application
proficient
particular,
demonstrate
superior
effectiveness
attributed
electrostatic
bioadhesion
tissues,
However,
continued
efforts
are
essential
further
optimize
CNLC
formulations
validate
clinical
utility,
ensuring
advancements
technology
improved
patient
outcomes.
International Journal of Current Pharmaceutical Research,
Год журнала:
2024,
Номер
unknown, С. 10 - 20
Опубликована: Янв. 15, 2024
Nanomedicine
along
with
nano-delivery
systems,
are
a
young
but
fast-emerging
science
in
which
tiny
materials
used
as
diagnostic
tools
or
to
deliver
therapeutic
drugs
specific
targeted
locations
controlled
manner.
Nanotechnology
has
numerous
advantages
the
treatment
of
chronic
human
diseases
through
site-specific
and
target-oriented
delivery
precise
medications.
There
have
recently
been
several
notable
applications
nanomedicine
(chemotherapeutic
agents,
biological
immunotherapeutic
so
on)
various
disorders.
Efficient
use
pricey
medications
excipients,
well
cost
savings
manufacturing
Beneficial
patients,
improved
therapy,
comfort,
standard
living.
Lipids
proposed
an
alternate
carrier
circumvent
constraints
polymeric
nanoparticles,
notably
for
lipophilic
medicines.
Such
small
particles
lipid
known
solid
nanoparticles
(SLNs),
they
gaining
popularity
among
formulators
all
over
world.
SLNs
colloidal
carriers
that
were
developed
last
decade
replacement
traditional
carriers.
Lipid
caught
interest
researchers
during
two
decades
shown
considerable
success
since
first
clinical
approval
Doxil
1995.
Simultaneously,
significant
promise
conveying
nucleic
acid
medications,
proven
by
RNA
treatments
mRNA
COVID-19
vaccination.
Colloids and Interface Science Communications,
Год журнала:
2024,
Номер
61, С. 100794 - 100794
Опубликована: Июль 1, 2024
Fungal
keratitis
is
a
globally
blinding
eye
disease
caused
by
fungi,
with
more
than
1.05
million
cases
diagnosed
annually,
mainly
in
Asia.
It
the
most
common
form
of
infectious
keratitis,
accounting
for
approximately
40–50%
microbial
cases.
The
difficult
to
treat
and
prognosis
often
poor.
Conventional
antimicrobial
therapies,
which
are
mainstay
treatment,
face
problems
off-target
toxicity,
low
bioavailability,
drug-resistant
fungi.
In
recent
years,
novel
drug
delivery
systems
have
emerged
as
promising
alternative.
These
improve
stability,
extend
residence
time,
control
release,
target
specific
tissues
cells,
reduce
toxic
side
effects.
Nanoparticle-based
particularly
compelling.
aim
this
paper
elucidate
mechanisms
advances
nanoparticle-based
antifungal
therapy
provide
new
perspectives
on
treatment
fungal
keratitis.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Glaucoma,
a
leading
cause
of
irreversible
blindness
worldwide,
is
characterized
by
optic
nerve
damage
often
associated
with
elevated
intraocular
pressure
(IOP).
Although
gas
therapies
hold
promise
for
glaucoma
treatment,
the
limitations
single‐gas
strategies
constrain
their
therapeutic
efficacy.
Here,
photoresponsive
dual‐gas
nanomedicine
developed
targeted
therapy.
The
nanomedicine,
PdH‐D‐S,
engineered
synthesizing
mesoporous
palladium
hydride
(meso‐PdH)
efficient
hydrogen
(H₂)
storage
capacity
and
abundant
pore
channels,
followed
surface
modification
DSPE‐mPEG
loading
sodium
nitroprusside
(SNP)
as
nitric
oxide
(NO)
donor.
PdH‐D‐S
penetrates
cornea
to
reach
IOP‐regulating
tissues,
including
trabecular
meshwork
Schlemm's
canal.
Upon
808
nm
laser
excitation,
releases
H₂
NO
in
controlled
manner.
activates
AKT/p‐AKT/eNOS/sGC
signaling
pathway,
while
binds
soluble
guanylate
cyclase
(sGC),
converting
guanosine
triphosphate
(GTP)
cyclic
monophosphate
(cGMP),
relaxing
cells
enhancing
aqueous
humor
outflow.
This
system
demonstrates
high
efficacy
lowering
IOP
offers
mechanistic
advancement
treatment
through
synergistic
Journal of Ocular Pharmacology and Therapeutics,
Год журнала:
2024,
Номер
40(3), С. 160 - 172
Опубликована: Фев. 23, 2024
Fungal
keratitis
(FK)
is
a
dangerous
corneal
infection
that
common
in
tropical
and
subtropical
areas.
Its
incidence
extremely
high,
ocular
trauma
contact
lenses
can
lead
to
FK,
but
its
treatment
such
as
using
topical
antifungal
eye
drop
instillation
often
less
effective
because
of
several
drawbacks
the
drugs
typically
used,
including
limited
penetration,
high
frequency
dosing,
poor
biocompatibility,
potential
for
severe
drug
reactions.
Therefore,
development
novel
delivery
devices
FK
urgent.
The
urgent
need
treat
has
led
techniques,
nanoparticles
(NPs),
