Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(8)
Опубликована: Июль 11, 2023
In
addition
to
the
first
synthesis
of
natural
bromophenol
butyl
2-(3,5-dibromo-4-hydroxyphenyl)acetate
(1),
indene
derivatives
34
and
35
were
synthesized
from
3-phenylpropenal
in
BBr3
medium.
Five
known
bromophenols
some
by
methods.
Cholinesterase
(ChEs)
inhibitors
reduce
breakdown
acetylcholine
are
used
treatment
Alzheimer's
disease
(AD)
dementia
symptoms.
The
inhibition
effects
all
obtained
compounds
examined
towards
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE)
α-glycosidase
enzymes.
All
demonstrated
strong
against
both
cholinergic
For
determination
Ki
values
novel
Lineweaver-Burk
graphs
obtained.
found
ranging
0.13-14.74
nM
for
AChE,
5.11-23.95
BChE,
63.96-206.78
α-glycosidase,
respectively.
their
exhibit
effective
profile
when
compared
positive
controls.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Март 5, 2024
,
known
as
parsley,
is
a
fragrant
herb
that
possesses
rich
heritage
of
utilization
in
traditional
medicinal
practices.
In
this
study,
we
annotated
the
phytocontents
aqueous
and
ethanolic
extracts
Current Alzheimer Research,
Год журнала:
2024,
Номер
21(2), С. 141 - 154
Опубликована: Фев. 1, 2024
Background:
As
individuals
age,
they
may
develop
Alzheimer's
disease
(AD),
which
is
characterized
by
difficulties
in
speech,
memory
loss,
and
other
issues
related
to
neural
function.
Cycloastragenol
an
active
ingredient
of
Astragalus
trojanus
has
been
used
treat
inflammation,
aging,
heart
disease,
cancer.
Objectives:
This
study
aimed
explore
the
potential
therapeutic
benefits
cycloastragenol
rats
with
experimentally
induced
AD.
Moreover,
underlying
molecular
mechanisms
were
also
evaluated
measuring
Nrf2
HO-1,
are
involved
oxidative
stress,
NFκB
TNF-α,
BCL2,
BAX,
caspase-3,
apoptosis.
Methods:
Sprague-Dawley
given
70
mg/kg
aluminum
chloride
intraperitoneally
daily
for
six
weeks
induce
Following
AD
induction,
25
oral
gavage
three
weeks.
Hippocampal
sections
stained
hematoxylin/
eosin
anti-caspase-3
antibodies.
The
Nrf2,
NFκB,
caspase-3
gene
expressions
protein
levels
samples
analyzed.
Results:
significantly
improved
rats'
behavioral
test
performance.
It
strengthened
organization
hippocampus.
performance
hippocampal
structure
rats.
caused
a
marked
decrease
expression
was
associated
increase
HO-1.
Conclusion:
hippocampus
enhanced
outcomes
tests,
decreased
concentration
AChE
brain,
exerted
antioxidant
anti-inflammatory
effects.
Antiapoptotic
effects
noted,
leading
significant
improvements
cognitive
function,
memory,
behavior
treated
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Medicinal
and
aromatic
plants
such
as
Crocus
cancellatus,
Scilla
Siberica
subsp.
armena,
Juniperus
oxycedrus
Anthriscus
nemorosa
have
many
different
biological
activities.
While
antioxidants
are
significant
in
preventing
diseases,
inhibition
of
metabolic
enzymes
is
also
effective
diseases.
In
this
study,
antioxidant
activities
water,
ethanol,
dichloromethane
extracts
four
medicinal
plant
species
were
determined
by
1,1-diphenyl-2-picrylhydrazyl
(DPPH•)
2,20-azino-bis-3-ethylbenzthiazoline-6-sulphonic
acid
(ABTS•+)
radical
scavenging
Cu2+,
Fe+3,
Fe3+-2,4,6-tris(2-pyridyl)-S-triazine
(TPTZ)
reducing
assays.
Enzyme
studies
performed
with
acetylcholinesterase,
butyrylcholinesterase,
carbonic
anhydrase
I
II
isoenzymes.
The
ethanol
extract
A.
showed
the
highest
activity
DPPH
ABTS
assays
(IC50:
17.36
µg
mL-1,
IC50:
7.02
mL-1).
Fe3+
assay,
(1.96±0.060
Cu2+
J.
(1.773±0.066
Fe3+-TPTZ
S.
siberica
(1.256±0.011
enzyme
results,
it
was
that
all
inhibited
studied.
As
a
result
these
high
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(8)
Опубликована: Июль 11, 2023
In
addition
to
the
first
synthesis
of
natural
bromophenol
butyl
2-(3,5-dibromo-4-hydroxyphenyl)acetate
(1),
indene
derivatives
34
and
35
were
synthesized
from
3-phenylpropenal
in
BBr3
medium.
Five
known
bromophenols
some
by
methods.
Cholinesterase
(ChEs)
inhibitors
reduce
breakdown
acetylcholine
are
used
treatment
Alzheimer's
disease
(AD)
dementia
symptoms.
The
inhibition
effects
all
obtained
compounds
examined
towards
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE)
α-glycosidase
enzymes.
All
demonstrated
strong
against
both
cholinergic
For
determination
Ki
values
novel
Lineweaver-Burk
graphs
obtained.
found
ranging
0.13-14.74
nM
for
AChE,
5.11-23.95
BChE,
63.96-206.78
α-glycosidase,
respectively.
their
exhibit
effective
profile
when
compared
positive
controls.
