Harmful Algae, Год журнала: 2024, Номер 137, С. 102667 - 102667
Опубликована: Июнь 12, 2024
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Abstract Advanced periodontitis initiates with Porphyromonas gingivalis ( P. ) infection, which subsequently triggers chronic inflammation, immune imbalance, and ultimately causes alveolar bone resorption. Traditional periodontal treatment focuses on the elimination of triggering factors, but tend to ignore improvement inflammatory microenvironment remodeling osteogenic mineralization space. Herein, zinc‐aluminum layered double hydroxide nanosheets (LDHs) loaded icariin (ICA) are encapsulated into a gallic acid (GA)‐modified hydroxybutyl chitosan hydrogel (GA‐HBC), giving rise customized system named GA‐HBC‐LIC, can sequentially actualize antibacterial, anti‐inflammatory, remineralization functions. A neutral chemical‐humoral space is created for osteogenesis via means sequential regulation by smart hydrogel. Concomitantly, appropriate mechanical properties degradation performance provide desirable physical remineralization. In spatiotemporal modulation hydrogel, zinc finger E‐box‐binding homeobox 1 (ZEB1) target released ions (Zn 2+ action promotes macrophage polarization from M1 M2 phenotype, thereby releasing cytokines conducive tissue regeneration. sum, this study highlights critical role inflammation maintenance in regeneration tissues, offering new insights clinical management periodontitis.
Язык: Английский
Процитировано
0
Computers & Mathematics with Applications, Год журнала: 2025, Номер 187, С. 231 - 248
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
Cellulose, Год журнала: 2024, Номер 31(5), С. 2989 - 3013
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
3
European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 201, С. 106858 - 106858
Опубликована: Июль 20, 2024
Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as promising candidate sustained delivery. Despite its unique properties allow to load release proteins mitigating burst extending effects, precise control over Laponite-protein interactions remains challenging since it depends on complex interplay factors whose implication not fully understood yet. aim this review article shed light issue, providing comprehensive discussion the influencing protein loading release, including physicochemical nanoclay proteins, pH, dispersion buffer, clay/protein concentration degradation. Furthermore, we thoroughly revise bioactive that have been delivered from formulations containing nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, avenue currently under extensive investigation.
Язык: Английский
Процитировано
3
Applied Organometallic Chemistry, Год журнала: 2024, Номер 38(9)
Опубликована: Июнь 24, 2024
In this work, new pH‐sensitive and antibacterial drug carrier systems based on silver nanoparticles (AgNPs) embedded in the interlayer of laponite (Lap) presence chitosan (CTS) for controllable release sunitinib maleate (STM) were developed. Silver ions first loaded into Lap, CTS‐based hybrid bionanocomposite (Lap@CTS@AgNPs@STM) was obtained citric acid as a cross‐linker agent. The successful preparation nanocarrier Ag NPs formation thoroughly confirmed using techniques such FTIR, XRD, TGA, SEM, TEM. TEM images illustrated excellent distribution structure Lap@CTS@AgNPs. as‐prepared samples showed anticancer behavior. STM mechanism studied Korsmeyer–Peppas Higuchi kinetic models. Furthermore, vitro cytotoxicity tests carried out against both bacteria S. aureus E. coli MCF‐7 cell lines, respectively, to prove effectiveness synthesized multifunctional biomedical applications.
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Diabetic wounds remain a critical clinical challenge due to their harsh microenvironment, which impairs cellular function, hinders re-epithelialization and tissue remodeling, slows healing. Injectable nanocomposite hydrogel dressings offer promising strategy for diabetic wound repair. In this study, we developed an injectable dressing (HDL@W379) using LAP@W379 nanoparticles hyaluronic acid-based (HA-ADH-ODEX). This provided sustained, pH-responsive release of W379 antimicrobial peptides, effectively regulating the microenvironment enhance The HDL@W379 featured multifunctional properties, including mechanical stability, injectability, self-healing, biocompatibility, adhesion. vitro, achieved synergistic biofilm elimination subsequent activation basal cell migration endothelial tube formation. Pathway analysis indicated that enhances through MEK/ERK pathway activation. methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, accelerated healing by inhibiting bacterial proliferation promoting re-epithelialization, regenerating granulation tissue, enhancing collagen deposition, facilitating angiogenesis. Overall, continuously regulate offers innovative approach treating chronic wounds.
Язык: Английский
Процитировано
2
Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149642 - 149642
Опубликована: Фев. 13, 2024
Язык: Английский
Процитировано
2
Coatings, Год журнала: 2024, Номер 14(3), С. 308 - 308
Опубликована: Март 2, 2024
Osteoarthritis (OA) is characterized by cartilage degeneration and synovial inflammation, with chondrocytes playing a pivotal role in this disease. However, inflammatory mediators, mechanical stress, oxidative stress can compromise functionality. The occurrence progression of OA are intrinsically linked to the immune response. Current research on treatment mainly concentrates synergistic application drugs tissue engineering. surface engineered hydrogel materials be immunomodified affect function drug therapy, gene cell therapy. Prior studies have concentrated drug-loading hydrogels but overlooked immunomodulatory chondrocytes. These modifications inhibit proliferation differentiation chondrocytes, reduce response, promote regeneration. immunomodification significantly enhance their efficacy OA. Thus, engineering has significant potential for treating osteoarthritis.
Язык: Английский
Процитировано
2
ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(10), С. 5763 - 5777
Опубликована: Май 9, 2024
This study focuses on the development and evaluation of injectable drug delivery systems for long-acting treatment rheumatoid arthritis. Four types poly(ortho ester)-polyesters (POC2, POC3, POL2, POL3) were synthesized by polycondensation reactions between an ortho ester diamine monomer active esters oligocaprolactone diols (A-OCL) or oligolactide (A-OLA) with different molecular weights exhibited discrepant zero-shearing viscosities hydrophilic–hydrophobic properties. The degradation behaviors collectively controlled surface erosion bulk mechanisms, accelerated at pH 5.0 was observed due to acid-responsive hydrolysis groups. Consequently, release indomethacin (IND) well sustained kinetics fitting Ritger–Peppas model. After being injected subcutaneously once into adjuvant-induced arthritis rats, formulation IND-POC2 slowly released IND up 14 days showed best therapeutic effects effectively alleviating swelling joints, bone erosion, expression pro-inflammatory factors. To sum up, this research demonstrated cheerful prospect obtained functional viscous ester)-polyester fluid in disease.
Язык: Английский
Процитировано
1
Plant Physiology and Biochemistry, Год журнала: 2024, Номер 215, С. 109049 - 109049
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
1