Bioengineering,
Год журнала:
2024,
Номер
11(11), С. 1078 - 1078
Опубликована: Окт. 28, 2024
Docetaxel
has
exhibited
excellent
therapeutic
effects
in
cancer
treatment;
however,
its
hydrophobicity,
short
blood
circulation
time,
and
high
toxicity
restrict
clinical
application.
The
use
of
mPEG-PLA
micelles
to
deliver
docetaxel
into
the
body
been
verified
as
an
effective
approach
enhance
efficacy.
However,
are
easily
disassembled
bloodstream,
which
can
lead
premature
drug
release.
To
broaden
application
scenarios
mPEG
PLA
micelles,
we
utilized
π–π
stacking
effect
intermolecular
force
design
a
novel
mPEG-PLA-Lys(Fmoc)
micelle
stability
permeability
drug-loaded
micelles.
result
showed
that
for
injection
did
not
alter
tissue
selectivity
docetaxel.
Intravenous
nude
mice
better
antitumor
efficacy
than
tumor
recurrence
rate
is
0%,
significantly
lower
(100%).
designed
by
this
research
institute
anticipated
improve
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 15, 2025
Nanotechnology
has
experienced
significant
advancements,
attracting
considerable
attention
in
various
biomedical
applications.
This
innovative
study
synthesizes
and
characterizes
Ge/PLA/AuNCs
(gelatin/PLA/gold
nanocomposites)
using
Syzygium
cumini
extract
to
evaluate
their
The
UV–Visible
spectroscopy
results
an
absorption
peak
at
534
nm
were
primarily
confirmed
by
synthesis.
FTIR
spectrum
showed
functional
groups
the
XRD
patterns
crystalline
shape
structure
of
nanocomposites.
FESEM
HRTEM
a
oval
with
average
particle
size
21
nm.
Ge/PLA/AuNC's
remarkable
antioxidant
activity,
as
evidenced
DPPH
(70.84
±
1.64%),
ABTS
activity
(86.17
1.96%),
reducing
power
(78.42
1.48%)
concentration
100
μg/mL
was
observed.
zone
inhibition
against
Staphylococcus
aureus
(19.45
0.89
mm)
Echericia
coli
(20.83
0.97
revealed
excellent
antibacterial
Ge/PLA/AuNCs.
anti-diabetic
supported
α-amylase
(82.56
1.49%)
α-glucosidase
(80.27
1.57%).
anti-Alzheimer
AChE
(76.37
1.18%)
BChE
(85.94
1.38%)
enzymes.
In
vivo
studies
zebrafish
embryos
that
have
biocompatibility
nontoxicity.
SH-SY5Y
cell
line
demonstrated
improved
viability
(95.27
1.62%)
enhanced
neuronal
growth
following
treatment.
conclusion,
present
highlights
cost-effective
non-toxic
properties
Furthermore,
it
presents
attractive
promising
approach
for
future
Molecules,
Год журнала:
2024,
Номер
29(9), С. 2077 - 2077
Опубликована: Апрель 30, 2024
Cancer
is
one
of
the
major
causes
death,
and
its
negative
impact
continues
to
rise
globally.
Chemotherapy,
which
most
common
therapy,
has
several
limitations
due
tremendous
side
effects.
Therefore,
developing
an
alternate
therapeutic
agent
with
high
biocompatibility
indeed
needed.
The
anti-oxidative
effects
bioactivities
different
crude
extracts
marine
algae
have
been
evaluated
both
in
vitro
vivo.
In
present
study,
we
synthesized
aqueous
extract
(HA)
from
Amphiroa
anceps,
then,
a
liposome
was
formulated
for
that
(NHA).
were
characterized
using
photophysical
tools
like
dynamic
light
scattering,
UV–visible
spectroscopy,
FTIR,
scanning
electron
microscopy,
GC-MS
analysis.
SEM
image
revealed
size
range
112–185
nm
NHA
results
showed
presence
octadecanoic
acid
n-Hexadecanoic
majority.
anticancer
activity
studied
A549
cells,
inhibited
cancer
cells
dose-dependently,
highest
killing
92%
at
100
μg/mL.
vivo
studies
zebrafish
model
neither
HA
nor
anceps
any
teratogenic
effect.
outcome
our
study
can
be
potential
drug
candidate
inhibiting
good
up
dose
ADMET & DMPK,
Год журнала:
2025,
Номер
unknown, С. 2554 - 2554
Опубликована: Янв. 3, 2025
Despite
significant
advancements
in
cancer
therapies,
chemotherapeutics
continue
to
be
the
mainstay
for
treating
patients,
with
5-fluorouracil
(5-FU)
being
commonly
used
various
cancers.
However,
its
limited
ability
penetrate
cell
membranes
and
short
half-life,
caused
by
rapid
metabolism,
necessitate
frequent
administration
of
high
doses
maintain
effective
therapeutic
levels.
This
study
aimed
synthesize
oxidized
sodium
alginate
(OSA)
derivatives
create
OSA
nanoparticles
loaded
5-FU
(OSANP@
5-FU),
promoting
diketo
tautomers,
evaluate
their
photophysical
properties,
release
profile,
anticancer
activity
minimal
toxicity.
The
investigation
encompassed
physicochemical
characterization,
encapsulation
efficiency,
kinetics
at
pH
2.2
7.4,
viability
assessment
via
MTT
assay
V79
cells,
vitro
efficacy
A375
line.
Steady-state
absorption
emission
confirmed
presence
advantageous
diketone
tautomers
5-FU,
indicating
radiative
transitions
from
second
singlet
excited
state
ground
(S2→S0)
drug's
within
polymeric
nanostructure.
Dynamic
light
scattering
revealed
that
nanoparticles,
initially
177.8
nm,
grew
226.6
nm
after
encapsulating
retaining
zeta
potential
stability.
With
a
68%
studies
showed
46
54
%
released
across
different
levels
510
minutes.
In
acidic
conditions,
there
is
greater
than
neutral
levels,
pH-responsive
profile
beneficial
treatment,
mechanism
OSANPs
following
Fickian
diffusion
as
identified
Korsmeyer-Peppas
mathematical
model
formulation
showing
improved
efficacy.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 270 - 270
Опубликована: Фев. 18, 2025
Background/Objectives:
This
study
explored
the
antitumor
effect
of
Passiflora
incarnata
leaves'
nanoformulation
(N-EEP)
in
fibroblasts,
A375
cell
lines,
and
vivo
using
Dalton's
lymphoma
ascites
(DLA)-bearing
mice.
Methods:
N-EEP
treatment
could
significantly
slow
scratch
closing
cells
compared
to
extract
itself
(EEP).
Results:
The
hemolytic
assay
showed
that
had
less
than
2%
hemolysis,
making
formulation
highly
biocompatible.
In
administration
delayed
tumor
growth
rate,
reduced
weight
gain,
increased
tumor-bearing
mice's
life
span.
Furthermore,
ascitic
were
aspirated
from
investigated
for
various
gene
expressions.
suppressor
p53,
which
plays
a
significant
role
mitochondrial-mediated
apoptosis
pathway,
was
found
be
elevated
animals
treated
with
N-EEP.
We
assessed
cytotoxicity
isolated
DLA
induced
mice
both
trypan
blue
MTT
assays,
while
apoptotic
studies
conducted
Hoechst
staining.
Results
assays
indicated
nearly
80%
killed
by
(200
μg/mL).
Additionally,
apoptosis,
characterized
condensed
nuclei,
observed
after
treatment,
confirming
one
modes
death
caspase-dependent
apoptosis.
Conclusions:
Our
suggests
upregulating
p53
expression
inducing
