Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1462 - 1462
Опубликована: Ноя. 28, 2024
Upregulation
of
reactive
oxygen
species
(ROS)
levels
is
a
principal
feature
observed
in
the
brains
neurodegenerative
diseases
such
as
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD).
In
these
diseases,
oxidative
stress
can
disrupt
blood–brain
barrier
(BBB).
This
disruption
allows
neurotoxic
plasma
components,
blood
cells,
pathogens
to
enter
brain,
leading
increased
ROS
production,
mitochondrial
dysfunction,
inflammation.
Collectively,
factors
result
protein
modification,
lipid
peroxidation,
DNA
damage,
and,
ultimately,
neural
cell
damage.
this
review
article,
we
present
mechanisms
by
which
damage
leads
BBB
breakdown
brain
diseases.
Additionally,
summarize
potential
therapeutic
approaches
aimed
at
reducing
that
contributes
Язык: Английский
Highly Sensitive Detection of Glucose in the Presence of Serum Based on Signal Amplification of Persistent Luminescence Nanoparticles Functionalized by Glucose Oxidase
Advanced Optical Materials,
Год журнала:
2025,
Номер
13(4)
Опубликована: Янв. 17, 2025
Abstract
A
new
method
is
presented
for
the
in
vitro
detection
of
glucose
using
oxidase
(GOx)
covalently
linked
to
persistent
luminescent
nanoparticles
(PLNPs).
This
ensures
both
sensitive
and
specific
by
exploiting
enhanced
luminescence
PLNPs
presence
H
2
O
,
generated
an
enzymatic
reaction.
To
this
end,
three
different
composed
ZnGa
4
:Cr
3+
(ZGO)
are
prepared
hydrothermal
synthesis
at
120
°C
6
h
(ZGO1),
12
(ZGO2),
24
(ZGO3),
followed
a
calcination
500
°C,
resulting
with
average
hydrodynamic
diameter
100
nm
±
5
after
grinding
centrifugation.
These
efficiently
functionalized
GOx,
via
PEG
linker.
Following
production
reaction
between
GOx
bound
ZGO
surface
present
100‐fold
diluted
serum,
significant
increase
signal
observed.
phenomenon
most
pronounced
ZGO2,
which
limit
0.01
µ
m
range
from
0.05
1
obtained.
results
demonstrate
innovative
potential
technique
monitoring,
opening
up
avenues
real‐time
monitoring
effective
management
diabetes.
Язык: Английский
Secondary metabolite profile and free-radical scavenging activity of ethyl acetate extract of bidara fruit and leaves (ziziphus mauritiana)
IOP Conference Series Earth and Environmental Science,
Год журнала:
2025,
Номер
1441(1), С. 012013 - 012013
Опубликована: Янв. 1, 2025
Abstract
Ziziphus
Mauritiana
has
high
economic
value
but
is
still
considered
a
nuisance
plant
for
most
people.
Not
only
are
the
fruit
and
some
parts
of
Z.
rich
in
nutrients,
they
also
contain
bioactive
compounds
that
can
benefit
health.
This
study
aimed
to
provide
information
on
profile
secondary
metabolites
free-radical
scavenging
activity
leaf
extracts.
The
consisted
four
stages:
sample
powder
preparation,
extraction
process,
phytochemical
screening,
assay
by
DPPH
(2,2-Diphenyl-1-picrylhdrazyl)
method.
yield
ethyl
acetate
extract
leaves
obtained
from
maceration
process
was
9.86
g
(3.28%)
12.92
(4.30%),
respectively.
Phytochemical
screening
showed
contained
flavonoids,
tannins,
terpenoids,
steroids.
Both
extracts
strong
category
(IC
50
=
50-100
ppm).
better
66.09
ppm)
than
73.39
results
which
act
as
free
radical
scavengers
be
used
alternative
food
sources
with
potential
antioxidant
properties.
Язык: Английский