Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 73 - 104
Опубликована: Янв. 1, 2025
Chemical Engineering Journal, Год журнала: 2021, Номер 432, С. 134146 - 134146
Опубликована: Дек. 29, 2021
Язык: Английский
Процитировано
165
Molecules, Год журнала: 2021, Номер 26(5), С. 1486 - 1486
Опубликована: Март 9, 2021
Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall nuts and other plant sources. A myriad of pharmaceutical biological applications in medical field has been well recognized tannic acid. Among these effects, potential anticancer activities against several solid malignancies such as liver, breast, lung, pancreatic, colorectal ovarian cancers have reported. was found play maestro-role tuning oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R axis, VEGF/VEGFR CXCL12/CXCR4 axes. The combinational beneficial effects with conventional chemotherapeutic drugs clearly demonstrated literature synergistic effect enhancement chemo-sensitivity resistant cases. Yet, clinical limited owing its poor lipid solubility, low bioavailability, off-taste, short half-life. To overcome obstacles, novel drug delivery systems employed deliver aim improving and/or efficacy cancer cells. are types organic metallic nanoparticles. In this review, authors focus on molecular mechanisms neoplastic diseases that can be used for an attempt provide systemic reference promote development cheap system management.
Язык: Английский
Процитировано
109
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139177 - 139177
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2021, Номер 178, С. 193 - 228
Опубликована: Фев. 22, 2021
Язык: Английский
Процитировано
75
Heliyon, Год журнала: 2022, Номер 8(9), С. e10654 - e10654
Опубликована: Сен. 1, 2022
Due to their natural availability, biocompatibility, biodegradability, nontoxicity, flexibility, as well improved structural and functional characteristics, pectin pectin-based nanocomposites have become an interesting area of numerous researchers. Pectin is a polysaccharide that comes from plants used in variety products. The significance its modified number applications has been shown reviews. On uses pharmaceutical medication delivery, there are, however, few review publications. majority papers on do not structure explanations drug distribution medicinal application. biological application nanocomposite also explained this review, along with recent publication. As result, the goal was in-depth analysis summarize nanocomposites. exceptional physicochemical are remarkable materials for applications. In addition enhancing immune system, controlling blood cholesterol, other things, they anticancer, antidiabetic, antioxidant, anti-inflammatory, immunomodulatory, antibacterial properties. Because biocompatibility properties allow regulated release, received lot interest carriers targeted delivery systems. They administer medications treat cancer, inflammation, pain, Alzheimer's, bacteria, relax muscles. This found derivatives better efficiency viable candidates wide range It advised conduct further research subject toxicity order produce commercial formulations can serve both therapeutic agents carriers.
Язык: Английский
Процитировано
67
International Journal of Biological Macromolecules, Год журнала: 2022, Номер 217, С. 1 - 18
Опубликована: Июль 7, 2022
Язык: Английский
Процитировано
62
Bioactive Materials, Год журнала: 2022, Номер 20, С. 221 - 242
Опубликована: Май 31, 2022
Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical architecture and pathological microenvironment including enhanced oxidative stress inflammation. Conventional strategies, such as control of implant microstructure or introduction growth factors, have limited functions failing manage these complex environments. Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes (CuTA@SF) provide suitable for OCD regeneration. The incorporation CuTA endowed SF uniform elevated hydrophilicity. In vitro cultivation mesenchymal stem cells (MSCs) chondrocytes showed that CuTA@SF accelerated cell proliferation viability, well had antioxidant antibacterial properties. Under inflammatory environment stimulation IL-1β, still possessed potential promote MSC osteogenesis deposition cartilage-specific extracellular matrix (ECM). proteomics analysis further confirmed promoted ECM synthesis. full-thickness model rabbit, displayed successfully in situ regeneration, evidenced by micro-CT, histology (HE, S/O, toluidine blue staining) immunohistochemistry (Col I aggrecan immunostaining). Therefore, is promising biomaterial targeted at regeneration OCD.
Язык: Английский
Процитировано
60
Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(33), С. 12422 - 12440
Опубликована: Июль 19, 2022
Cancer is a severe public health problem. Resveratrol famous natural compound that has various bioactivities, such as antioxidant, anti-inflammatory, antidiabetic and antiaging activities. Especially, resveratrol could prevent treat cancers, oral, thyroid, breast, lung, liver, pancreatic, gastric, colorectal, bladder, prostate ovarian cancers. The underlying mechanisms have been widely studied, inhibiting cell proliferation, suppressing metastasis, inducing apoptosis, stimulating autophagy, modulating immune system, attenuating inflammation, regulating gut microbiota enhancing effects of other anticancer drugs. In this review, we summarize on different This paper helpful to develop resveratrol, crude extract containing or foods into functional food, dietary supplements auxiliary agents for prevention management
Язык: Английский
Процитировано
55
Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122457 - 122457
Опубликована: Июль 5, 2024
Язык: Английский
Процитировано
13
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131433 - 131433
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
10