International Ophthalmology, Год журнала: 2025, Номер 45(1)
Опубликована: Март 22, 2025
Язык: Английский
Acta Biomaterialia, Год журнала: 2022, Номер 165, С. 19 - 30
Опубликована: Март 12, 2022
Язык: Английский
Процитировано
95
International Journal of Bioprinting, Год журнала: 2023, Номер 9(5), С. 774 - 774
Опубликована: Июнь 14, 2023
Millions of individuals across the world suffer from corneal stromal diseases that impair vision. Fortunately, three-dimensional (3D) bioprinting technology which has revolutionized field regenerative tissue engineering makes it feasible to create personalized corneas. In this study, an artificial cornea with a high degree precision, smoothness, and programmable curvature was prepared by using digital light processing (DLP) 3D in one piece no support structure, construct then confirmed optical coherence tomography (OCT). On basis approach, we developed novel decellularized extracellular matrix/gelatin methacryloyl (CECM-GelMA) bioink can produce complex microenvironments highly tunable mechanical properties while retaining transmittance. Furthermore, composite hydrogel loaded human fibroblasts (hCFs), vitro experiments showed maintained cell viability expressed core proteins. vivo tests revealed might promote epithelial regeneration, keep matrix aligned, restore clarity. This demonstrates how crucial role CECM plays establishing favorable environment encourages transformation function. Therefore, corneas be rapidly customized have huge potential development analogs.
Язык: Английский
Процитировано
41
Aggregate, Год журнала: 2022, Номер 4(2)
Опубликована: Окт. 3, 2022
Abstract Digital light processing (DLP)‐based bioprinting technology has recently aroused considerable concerns as a strategy to deliver biomedical materials and/or specific cells create sophisticated structures for various tissue modeling and regeneration. In this review, we display concise introduction of DLP bioprinting, further discussion on the design manufacture (bio)printer with varied bioinks their applications toward drug screening, disease modeling, repair, regenerative medicine. Finally, advantages, challenges, perspectives printing platforms are detailed. It is believed that will play decisive role in field model medicine, mainly due its time‐efficient, higher resolution, amenability automation needs.
Язык: Английский
Процитировано
56
Engineered Regeneration, Год журнала: 2022, Номер 3(3), С. 292 - 309
Опубликована: Июль 16, 2022
Язык: Английский
Процитировано
54
Pharmaceutics, Год журнала: 2022, Номер 14(6), С. 1127 - 1127
Опубликована: Май 26, 2022
In recent decades, the demand for replacement of damaged or broken tissues has increased; this poses attention on problems related to low donor availability. For reason, researchers focused their field tissue engineering, which allows development scaffolds able mimic tissues’ extracellular matrix. However, and regeneration are complex since need guarantee an adequate hierarchical structured morphology as well mechanical, chemical, physical properties stand stresses enhance new formation. purpose, use inorganic materials fillers gained great interest in engineering applications, due wide range physicochemical capability induce biological responses. some issues still be faced improve efficacy. This review focuses description most effective nanomaterials (clays, nano-based nanomaterials, metal oxides, metallic nanoparticles) used properties. Particular been devoted combination with a applications. particular, skin, orthopaedic, neural have considered.
Язык: Английский
Процитировано
47
Tissue Engineering Part B Reviews, Год журнала: 2022, Номер 29(2), С. 167 - 187
Опубликована: Сен. 16, 2022
Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem cells and biomaterial scaffolds to create living tissue constructs restore patients' organs after injury or disease. Over the last decade, emerging technologies such as 3D bioprinting, biofabrication, supramolecular materials, induced pluripotent cells, organoids have entered field. While this rapidly evolving field expected great therapeutic potential, its development from bench bedside presents several ethical societal challenges. To make sure TE will reach ultimate goal improving patient welfare, these challenges should be mapped out evaluated. Therefore, we performed systematic review implications application for regenerative purposes, mentioned in academic literature. A search query PubMed, Embase, Scopus, PhilPapers yielded 2451 unique articles. After screening, 237 relevant biomedical articles published between 2008 2021 were included our review. We identified broad range could categorized under 10 themes. Seven themes trace bedside: (1) animal experimentation, (2) handling human tissue, (3) informed consent, (4) (5) risk safety, (6) clinical translation, (7) impact. Three represent safeguards all developmental phases: (8) scientific integrity, (9) regulation, (10) public involvement. This reveals since significant body literature has emerged on how design trials responsible manner. However, topics remain need more attention. These include acceptability alternative translational pathways outside trials, soft impacts society questions ownership over engineered tissues. Overall, overview help promote new interventions RM. It can also serve valuable resource educational tool scientists, engineers, clinicians by providing an considerations their work. Impact statement knowledge, first time been reviewed systematically. By gathering existing scholarly work identifying knowledge gaps, facilitates further research into other technologies. Moreover, it As such, may successful strategies
Язык: Английский
Процитировано
41
Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1368 - 1368
Опубликована: Апрель 29, 2023
Clay minerals are historically among the most used materials with a wide variety of applications. In pharmaceutical and biomedical fields, their healing properties have always been known in pelotherapy therefore attractive for potential. recent decades, research has focused on systematic investigation these properties. This review aims to describe relevant uses clays field, especially drug delivery tissue engineering purposes. minerals, which biocompatible non-toxic materials, can act as carriers active ingredients while controlling release increasing bioavailability. Moreover, combination polymers is useful it improve mechanical thermal polymers, well induce cell adhesion proliferation. Different types clays, both natural (such montmorillonite halloysite) synthetic origin (layered double hydroxides zeolites), were considered order compare them assess advantages different uses.
Язык: Английский
Процитировано
40
Pharmaceuticals, Год журнала: 2023, Номер 16(6), С. 821 - 821
Опубликована: Май 31, 2023
Hydrogels are widely used for therapeutic delivery applications due to their biocompatibility, biodegradability, and ability control release kinetics by tuning swelling mechanical properties. However, clinical utility is hampered unfavorable pharmacokinetic properties, including high initial burst difficulty in achieving prolonged release, especially small molecules (<500 Da). The incorporation of nanomaterials within hydrogels has emerged as viable option a method trap therapeutics the hydrogel sustain kinetics. Specifically, two-dimensional nanosilicate particles offer plethora beneficial characteristics, dually charged surfaces, degradability, enhanced properties hydrogels. nanosilicate–hydrogel composite system offers benefits not obtainable just one component, highlighting need detail characterization these nanocomposite This review focuses on Laponite, disc-shaped with diameter 30 nm thickness 1 nm. using Laponite explored, well examples Laponite–hydrogel composites currently being investigated prolong macromolecules such proteins. Future work will further characterize interplay between nanosilicates, polymer, encapsulated therapeutics, how each components affect
Язык: Английский
Процитировано
30
Results in Engineering, Год журнала: 2024, Номер 22, С. 102060 - 102060
Опубликована: Апрель 1, 2024
Creating functioning tissue constructions via bioprinting holds great promise for replacing diseased or damaged tissues, which employs precise control over the geometry and composition of build. This is an emerging technique that offers highly reproducible accurate computerized oversight constructed structures, potentially opening door to high-throughput production. Tissue are made by method using a solution biomaterial combination multiple biomaterials in hydrogel form, known as bioink, often encapsulates appropriate cell types. Hydrogels' aqueous three-dimensional networked environment has them attractive contender bio-ink formulation 3D printing recent times. Bio ink-based composites have however significant progress treating wounds, repairing muscles, bone, tissue, delivering drugs. The current review cutting-edge update on creation various bio ink formulations their uses biomedical industry. methods fabrication—laser-based, extrusion-based, inkjet-based bioprinting—are explained, illustrated, contrasted. Benefits drawbacks every discussed along with approach's difficulties, restrictions, potential future directions. Natural, synthetic, hybrid materials utilized bioinks also examined.
Язык: Английский
Процитировано
9
Hardware, Год журнала: 2024, Номер 2(1), С. 1 - 32
Опубликована: Янв. 26, 2024
Three-dimensional (3D) printing is a process in which materials are added together layer-by-layer manner to construct customized products. Many different techniques of 3D exist, vary used, cost, advantages, and drawbacks. Medicine increasingly benefiting from this transformative technology, the field ophthalmology no exception. The possible applications eyecare vast have been explored literature, such as 3D-printed ocular prosthetics, orbital implants, educational anatomical models, well surgical planning training. Novel drug-delivery platforms also emerged because printing, offering improved treatment modalities for several pathologies. Innovative research bioprinting viable tissues, including cornea, retina, conjunctiva, presenting an avenue regenerative ophthalmic therapies future. Although further development capabilities suitable required, represents powerful tool enhancing eye health.
Язык: Английский
Процитировано
8