International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
23(1), С. 401 - 401
Опубликована: Дек. 30, 2021
The
fabrication
of
collagen-based
biomaterials
for
skin
regeneration
offers
various
challenges
tissue
engineers.
purpose
this
study
was
to
obtain
a
novel
series
composite
based
on
collagen
and
several
types
clays.
In
order
investigate
the
influence
clay
type
drug
release
behavior,
obtained
materials
were
further
loaded
with
gentamicin.
Physiochemical
biological
analyses
performed
analyze
nanocomposite
after
nanoclay
embedding.
Infrared
spectra
confirmed
inclusion
in
polymeric
matrix
without
any
denaturation
triple
helical
conformation.
All
samples
revealed
slight
change
2-theta
values
pointing
toward
homogenous
distribution
layers
inside
obtaining
mainly
intercalated
collagen-clay
structures,
according
X-ray
diffraction
analyses.
porosity
collagen/clay
varied
depending
nanoparticles
sort.
Thermo-mechanical
indicated
enhanced
thermal
mechanical
features
composites
as
compared
neat
II
matrix.
Biodegradation
findings
supported
by
swelling
studies,
which
more
crosslinked
structure
due
additional
H
bonding
brought
nanoclays.
biology
tests
demonstrated
cellular
viability
but
also
antimicrobial
behavior
scaffolds.
presented
delayed
gentamicin
when
collagen-gentamicin
sample.
results
highlighted
importance
selection
affects
performances
promising
future
applications
biomedical
field.
Abstract
Digital
light
processing
(DLP)‐based
bioprinting
technology
has
recently
aroused
considerable
concerns
as
a
strategy
to
deliver
biomedical
materials
and/or
specific
cells
create
sophisticated
structures
for
various
tissue
modeling
and
regeneration.
In
this
review,
we
display
concise
introduction
of
DLP
bioprinting,
further
discussion
on
the
design
manufacture
(bio)printer
with
varied
bioinks
their
applications
toward
drug
screening,
disease
modeling,
repair,
regenerative
medicine.
Finally,
advantages,
challenges,
perspectives
printing
platforms
are
detailed.
It
is
believed
that
will
play
decisive
role
in
field
model
medicine,
mainly
due
its
time‐efficient,
higher
resolution,
amenability
automation
needs.
Pharmaceutics,
Год журнала:
2022,
Номер
14(6), С. 1127 - 1127
Опубликована: Май 26, 2022
In
recent
decades,
the
demand
for
replacement
of
damaged
or
broken
tissues
has
increased;
this
poses
attention
on
problems
related
to
low
donor
availability.
For
reason,
researchers
focused
their
field
tissue
engineering,
which
allows
development
scaffolds
able
mimic
tissues’
extracellular
matrix.
However,
and
regeneration
are
complex
since
need
guarantee
an
adequate
hierarchical
structured
morphology
as
well
mechanical,
chemical,
physical
properties
stand
stresses
enhance
new
formation.
purpose,
use
inorganic
materials
fillers
gained
great
interest
in
engineering
applications,
due
wide
range
physicochemical
capability
induce
biological
responses.
some
issues
still
be
faced
improve
efficacy.
This
review
focuses
description
most
effective
nanomaterials
(clays,
nano-based
nanomaterials,
metal
oxides,
metallic
nanoparticles)
used
properties.
Particular
been
devoted
combination
with
a
applications.
particular,
skin,
orthopaedic,
neural
have
considered.
Tissue Engineering Part B Reviews,
Год журнала:
2022,
Номер
29(2), С. 167 - 187
Опубликована: Сен. 16, 2022
Tissue
Engineering
(TE)
is
a
branch
of
Regenerative
Medicine
(RM)
that
combines
stem
cells
and
biomaterial
scaffolds
to
create
living
tissue
constructs
restore
patients'
organs
after
injury
or
disease.
Over
the
last
decade,
emerging
technologies
such
as
3D
bioprinting,
biofabrication,
supramolecular
materials,
induced
pluripotent
cells,
organoids
have
entered
field.
While
this
rapidly
evolving
field
expected
great
therapeutic
potential,
its
development
from
bench
bedside
presents
several
ethical
societal
challenges.
To
make
sure
TE
will
reach
ultimate
goal
improving
patient
welfare,
these
challenges
should
be
mapped
out
evaluated.
Therefore,
we
performed
systematic
review
implications
application
for
regenerative
purposes,
mentioned
in
academic
literature.
A
search
query
PubMed,
Embase,
Scopus,
PhilPapers
yielded
2451
unique
articles.
After
screening,
237
relevant
biomedical
articles
published
between
2008
2021
were
included
our
review.
We
identified
broad
range
could
categorized
under
10
themes.
Seven
themes
trace
bedside:
(1)
animal
experimentation,
(2)
handling
human
tissue,
(3)
informed
consent,
(4)
(5)
risk
safety,
(6)
clinical
translation,
(7)
impact.
Three
represent
safeguards
all
developmental
phases:
(8)
scientific
integrity,
(9)
regulation,
(10)
public
involvement.
This
reveals
since
significant
body
literature
has
emerged
on
how
design
trials
responsible
manner.
However,
topics
remain
need
more
attention.
These
include
acceptability
alternative
translational
pathways
outside
trials,
soft
impacts
society
questions
ownership
over
engineered
tissues.
Overall,
overview
help
promote
new
interventions
RM.
It
can
also
serve
valuable
resource
educational
tool
scientists,
engineers,
clinicians
by
providing
an
considerations
their
work.
Impact
statement
knowledge,
first
time
been
reviewed
systematically.
By
gathering
existing
scholarly
work
identifying
knowledge
gaps,
facilitates
further
research
into
other
technologies.
Moreover,
it
As
such,
may
successful
strategies
Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1368 - 1368
Опубликована: Апрель 29, 2023
Clay
minerals
are
historically
among
the
most
used
materials
with
a
wide
variety
of
applications.
In
pharmaceutical
and
biomedical
fields,
their
healing
properties
have
always
been
known
in
pelotherapy
therefore
attractive
for
potential.
recent
decades,
research
has
focused
on
systematic
investigation
these
properties.
This
review
aims
to
describe
relevant
uses
clays
field,
especially
drug
delivery
tissue
engineering
purposes.
minerals,
which
biocompatible
non-toxic
materials,
can
act
as
carriers
active
ingredients
while
controlling
release
increasing
bioavailability.
Moreover,
combination
polymers
is
useful
it
improve
mechanical
thermal
polymers,
well
induce
cell
adhesion
proliferation.
Different
types
clays,
both
natural
(such
montmorillonite
halloysite)
synthetic
origin
(layered
double
hydroxides
zeolites),
were
considered
order
compare
them
assess
advantages
different
uses.
International Journal of Bioprinting,
Год журнала:
2023,
Номер
9(5), С. 774 - 774
Опубликована: Июнь 14, 2023
Millions
of
individuals
across
the
world
suffer
from
corneal
stromal
diseases
that
impair
vision.
Fortunately,
three-dimensional
(3D)
bioprinting
technology
which
has
revolutionized
field
regenerative
tissue
engineering
makes
it
feasible
to
create
personalized
corneas.
In
this
study,
an
artificial
cornea
with
a
high
degree
precision,
smoothness,
and
programmable
curvature
was
prepared
by
using
digital
light
processing
(DLP)
3D
in
one
piece
no
support
structure,
construct
then
confirmed
optical
coherence
tomography
(OCT).
On
basis
approach,
we
developed
novel
decellularized
extracellular
matrix/gelatin
methacryloyl
(CECM-GelMA)
bioink
can
produce
complex
microenvironments
highly
tunable
mechanical
properties
while
retaining
transmittance.
Furthermore,
composite
hydrogel
loaded
human
fibroblasts
(hCFs),
vitro
experiments
showed
maintained
cell
viability
expressed
core
proteins.
vivo
tests
revealed
might
promote
epithelial
regeneration,
keep
matrix
aligned,
restore
clarity.
This
demonstrates
how
crucial
role
CECM
plays
establishing
favorable
environment
encourages
transformation
function.
Therefore,
corneas
be
rapidly
customized
have
huge
potential
development
analogs.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(6), С. 821 - 821
Опубликована: Май 31, 2023
Hydrogels
are
widely
used
for
therapeutic
delivery
applications
due
to
their
biocompatibility,
biodegradability,
and
ability
control
release
kinetics
by
tuning
swelling
mechanical
properties.
However,
clinical
utility
is
hampered
unfavorable
pharmacokinetic
properties,
including
high
initial
burst
difficulty
in
achieving
prolonged
release,
especially
small
molecules
(<500
Da).
The
incorporation
of
nanomaterials
within
hydrogels
has
emerged
as
viable
option
a
method
trap
therapeutics
the
hydrogel
sustain
kinetics.
Specifically,
two-dimensional
nanosilicate
particles
offer
plethora
beneficial
characteristics,
dually
charged
surfaces,
degradability,
enhanced
properties
hydrogels.
nanosilicate–hydrogel
composite
system
offers
benefits
not
obtainable
just
one
component,
highlighting
need
detail
characterization
these
nanocomposite
This
review
focuses
on
Laponite,
disc-shaped
with
diameter
30
nm
thickness
1
nm.
using
Laponite
explored,
well
examples
Laponite–hydrogel
composites
currently
being
investigated
prolong
macromolecules
such
proteins.
Future
work
will
further
characterize
interplay
between
nanosilicates,
polymer,
encapsulated
therapeutics,
how
each
components
affect
Results in Engineering,
Год журнала:
2024,
Номер
22, С. 102060 - 102060
Опубликована: Апрель 1, 2024
Creating
functioning
tissue
constructions
via
bioprinting
holds
great
promise
for
replacing
diseased
or
damaged
tissues,
which
employs
precise
control
over
the
geometry
and
composition
of
build.
This
is
an
emerging
technique
that
offers
highly
reproducible
accurate
computerized
oversight
constructed
structures,
potentially
opening
door
to
high-throughput
production.
Tissue
are
made
by
method
using
a
solution
biomaterial
combination
multiple
biomaterials
in
hydrogel
form,
known
as
bioink,
often
encapsulates
appropriate
cell
types.
Hydrogels'
aqueous
three-dimensional
networked
environment
has
them
attractive
contender
bio-ink
formulation
3D
printing
recent
times.
Bio
ink-based
composites
have
however
significant
progress
treating
wounds,
repairing
muscles,
bone,
tissue,
delivering
drugs.
The
current
review
cutting-edge
update
on
creation
various
bio
ink
formulations
their
uses
biomedical
industry.
methods
fabrication—laser-based,
extrusion-based,
inkjet-based
bioprinting—are
explained,
illustrated,
contrasted.
Benefits
drawbacks
every
discussed
along
with
approach's
difficulties,
restrictions,
potential
future
directions.
Natural,
synthetic,
hybrid
materials
utilized
bioinks
also
examined.
