Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(1), С. 585 - 611

Опубликована: Янв. 5, 2024

Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.

Язык: Английский

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Self‐Assembled Nanocomposite Hydrogels as Carriers for Demineralized Bone Matrix Particles and Enhanced Bone Repair

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(10)

Опубликована: Янв. 26, 2024

Demineralized bone matrix (DBM) has been widely used as an allogeneic alternative to autologous graft for repair. However, more extensive use of DBM is limited due its particulate nature after demineralization and rapid particle dispersion following irrigation, resulting in unpredictable osteoinductivity. Here, a new design injectable hydrogel carriers that combine self-healing ability osteogenic properties based on the self-assembly guanidinylated hyaluronic acid silica-rich nanoclays reported. The serve reversible linkages form dynamic network with guanidine moieties polymer chains. Gelation kinetics mechanical can be controlled by altering nanoclay content hydrogel. exerts crosslinks well retains overall performance high loading. exhibits great cytocompatibility effects mediated nanoclays. In vivo delivery using nanocomposite further demonstrates robust regeneration mouse calvarial defect model comparison delivered aqueous HA. This work suggests promising platform many applications including therapeutic tissue engineering.

Язык: Английский

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Hybrid Nanoparticle–Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications

ACS Nano, Год журнала: 2024, Номер 18(34), С. 22780 - 22792

Опубликована: Авг. 14, 2024

Hydrogel-based depots typically tend to remain where injected and have excellent biocompatibility but are relatively poor at controlling drug release. Nanoparticles (NPs) the opposite properties. The smaller NPs are, more likely they leave site of injection. Their is variable depending on material can be poor. However, good In these other properties, combining hydrogels leverage their advantages negate disadvantages. This review highlights rationale for hybrid NP-hydrogel systems in delivery, basic methods producing them, examples two addressed specific problems.

Язык: Английский

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Atomistic modelling and experimental study of tensile strength of nanocomposite hydrogel

International Journal of Mechanical Sciences, Год журнала: 2024, Номер 277, С. 109397 - 109397

Опубликована: Май 17, 2024

Язык: Английский

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3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release

Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(12), С. 3385 - 3403

Опубликована: Янв. 7, 2024

Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, proposes novel approach loading drugs into 3DPS employing first time post-printing loading. Thus, passive strategy molecular models is developed, demonstrating versatility capacity load molecules different charges sizes within matrix systems. This allows adapting wide range single ink, which simplifies speeds up technological development process with physico-chemical properties. Additionally, research, displacement three-dimensional Laponite matrices developed order enhance drug release through their disintegration capacity, resulting significant improvement diffusion hydrogel rapid Finally, our demonstrates that obtained vivo behavior, being non-obstructive allowing normal motility rats intestine.

Язык: Английский

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Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Molecules, Год журнала: 2024, Номер 29(12), С. 2823 - 2823

Опубликована: Июнь 13, 2024

Laponite® (LAP) is an intensively studied synthetic clay due to the versatility given by its layered structure, which makes it usable in various applications. This review describes multifaceted properties and applications of LAP aqueous dispersions gel systems. The first sections discuss structure interactions between discs medium under different conditions (such as ionic strength, pH, temperature, addition polymers) order understand function tailoring designed material. Additionally, explores aging phenomenon characteristic well development shake-gels incorporating LAP. second part shows most recent studies on materials containing with possible applicability drilling industry, cosmetics or care products biomedical fields. By elucidating remarkable ease integration into matrices, this underscores significance a key ingredient for creation next-generation tailored functionalities.

Язык: Английский

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Novel pH-sensitive of organic composite (kc-g-poly(AAc-co-AAm)/bentonite), synthesis and characterization candidate as a carrier for controlled release system in vitro to some drugs

Carbon letters, Год журнала: 2024, Номер 34(1), С. 505 - 517

Опубликована: Янв. 1, 2024

Язык: Английский

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Nanobioactive blood-derived shear-thinning biomaterial for tissue engineering applications

Applied Materials Today, Год журнала: 2024, Номер 38, С. 102250 - 102250

Опубликована: Май 25, 2024

Язык: Английский

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Fabrication and Characterization of Injectable Nanocomposite Hydrogel Containing PEG-PCL-PEG Copolymer/Montmorillonite Nanoparticles for Bone Tissue Regeneration

Arabian Journal for Science and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

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A predictive model for calculating the electrostatic intercalation efficiency of methotrexate-loaded laponite dependent on clay concentration and pH built from binding constants

Applied Clay Science, Год журнала: 2025, Номер 270, С. 107781 - 107781

Опубликована: Март 15, 2025

Язык: Английский

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