Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10540 - 10540

Опубликована: Июнь 23, 2023

Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding that can become life-threatening if not properly managed. Moreover, uncontrolled complicate surgical interventions, altering the outcome procedures. Therefore, to reduce risk complications decrease morbidity mortality associated with hemorrhage, it necessary use an effective hemostatic agent ensures immediate control bleeding. In recent years, there have been increasingly rapid advances developing novel generation biomaterials properties. Nowadays, wide array topical agents available, including chitosan-based shown outstanding properties such as antibacterial, antifungal, hemostatic, analgesic activity addition their biocompatibility, biodegradability, wound-healing effects. This review provides analysis discusses progress made performance, mechanism action, efficacy, cost, safety years.

Язык: Английский

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Polysaccharides from red seaweeds: Effect of extraction methods on physicochemical characteristics and antioxidant activities

Food Hydrocolloids, Год журнала: 2023, Номер 147, С. 109307 - 109307

Опубликована: Окт. 1, 2023

Язык: Английский

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Smart and versatile biomaterials for cutaneous wound healing

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

The global increase of cutaneous wounds imposes huge health and financial burdens on patients society. Despite improved wound healing outcomes, conventional dressings are far from ideal, owing to the complex process. Smart dressings, which sensitive or interact with changes in condition environment, have been proposed as appealing therapeutic platforms effectively facilitate healing. In this review, processes features existing biomaterials firstly introduced, followed by summarizing mechanisms smart responsive materials. Afterwards, recent advances designs versatile materials extensive applications for were submarined. Finally, clinical progresses, challenges future perspectives dressing discussed. Overall, mapping composition intrinsic structure their individual needs wounds, particular attention mechanisms, review is promising advance further progress designing drive translation.

Язык: Английский

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Modified chitosan: Insight on biomedical and industrial applications

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133526 - 133526

Опубликована: Июль 2, 2024

Язык: Английский

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Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Materials Today Bio, Год журнала: 2022, Номер 17, С. 100468 - 100468

Опубликована: Окт. 18, 2022

Uncontrolled bleeding remains as a leading cause of death in surgical, traumatic, and emergency situations. Management the hemorrhage development hemostatic materials are paramount for patient survival. Owing to their inherent biocompatibility, biodegradability bioactivity, biopolymers such polysaccharides polypeptides have been extensively researched become focus next-generation materials. The construction novel requires in-depth understanding physiological process, fundamental mechanisms, effects material chemistry/physics. Herein, we recapitulated common strategies status biopolymer-based Furthermore, mechanisms various molecular structures (components chemical modifications) summarized from microscopic perspective, design based on them introduced. From macroscopic forms materials, e.g., powder, sponge, hydrogel gauze, is compared, which may provide an enlightenment optimization hemostat design. It has also highlighted current challenges proposed future directions chemistry design, advanced form clinical application.

Язык: Английский

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Recent advances in biopolymer-based hemostatic materials

Regenerative Biomaterials, Год журнала: 2022, Номер 9

Опубликована: Янв. 1, 2022

Abstract Hemorrhage is the leading cause of trauma-related deaths, in hospital and prehospital settings. Hemostasis a complex mechanism that involves cascade clotting factors proteins result formation strong clot. In certain surgical emergency situations, hemostatic agents are needed to achieve faster blood coagulation prevent patient from experiencing severe hemorrhagic shock. Therefore, it critical consider appropriate materials designs for agents. Many have been fabricated as agents, including synthetic naturally derived polymers. Compared polymers, natural polymers or biopolymers, which include polysaccharides polypeptides, greater biocompatibility, biodegradability processibility. Thus, this review, we focus on biopolymer-based different forms, such powder, particles, sponges hydrogels. Finally, discuss currently clinical trials offer insight into next-generation hemostats translation.

Язык: Английский

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Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics

Advanced Materials, Год журнала: 2023, Номер 35(39)

Опубликована: Март 21, 2023

Short designer self-assembling peptide (dSAP) biomaterials are a new addition to the hemostat group. It may provide diverse and robust toolbox for surgeons integrate wound microenvironment with much safer stronger hemostatic capacity than conventional materials agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, internal medical bleeding (IMB), respect optimal formulation, dSAP ingenious nanofiber alternatives make bioactive neural scaffold, nasal packing, large coverage gastrointestinal surgery (esophagus, gastric lesion, duodenum, lower digestive tract), epicardiac cell-delivery carrier, transparent matrix barrier, so on. Herein, multiple surgical specialties, dSAP-biomaterial-based nano-hemostats achieve safe, effective, immediate hemostasis, facile healing, potentially reduce risks delayed rebleeding, post-operative or related complications. The biosafety vivo, indications, tissue-sealing quality, feasibility, local usability addressed comprehensively sequentially pursued develop useful techniques better performance. Here, state of art all-round advancements nano-hemostatic approaches provided. Relevant critical insights will inspire exciting investigations on nanotechnology, next-generation biomaterials, promising prospects clinics.

Язык: Английский

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White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 3, 2023

Post-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance. In-situ crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard achieve fast gelation, on-demand adhesion, wide feasibility at same time.A white-light crosslinkable natural milk-derived casein hydrogel bioadhesive presented for first time. Benefiting from abundant tyrosine residues, was synthesized by forming di-tyrosine bonds under white light ruthenium-based catalyst. We firstly optimized concentration of proteins initiators faster gelation higher mechanical strength. Then, we examined degradation, cytotoxicity, tissue hemostasis, healing ability hydrogels study their potential be used as bioadhesives.Rapid initiated an outdoor flashlight, cellphone or endoscopy lamp, which facilitates its usage during minimally invasive operations. The rapid enables 3D printing excellent hemostasis even liver due section injury. covalent binding between robust adhesion can withstand more than 180 mmHg blood pressure. Moreover, casein-based facilitate post-traumatic caused trauma biocompatibility.Casein-based bioadhesives developed in this pave way broad practical application emergency management.

Язык: Английский

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Synthesis and characterization of chitosan nanofibers for wound healing and drug delivery application

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 87, С. 104858 - 104858

Опубликована: Авг. 17, 2023

Язык: Английский

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Recent advances in biopolymer-based smart hydrogel for wound healing

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105990 - 105990

Опубликована: Сен. 1, 2024

Язык: Английский

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