Journal of drug targeting,
Год журнала:
2023,
Номер
31(8), С. 832 - 857
Опубликована: Авг. 14, 2023
Central
nervous
system
integrity
is
the
state
of
brain
functioning
across
sensory,
cognitive,
emotional-social
behaviors,
and
motor
domains,
allowing
a
person
to
realise
his
full
potential.
Thus,
disorders
seriously
affect
patients'
quality
life.
Efficient
drug
delivery
treat
remains
crucial
challenge
due
numerous
barriers,
particularly
blood-brain
barrier
(BBB),
which
greatly
impacts
ultimate
therapeutic
efficacy.
Lately,
nanocarrier
technology
has
made
huge
progress
in
overcoming
these
barriers
by
improving
solubility,
ameliorating
its
retention,
reducing
toxicity,
targeting
encapsulated
agents
different
tissues.
The
current
review
primarily
offers
an
overview
components
BBB
progress,
strategies,
contemporary
applications
nanocarriers,
specifically
lipid-based
nanocarriers
(LBNs),
treating
various
disorders.
Drug Delivery and Translational Research,
Год журнала:
2023,
Номер
14(2), С. 400 - 417
Опубликована: Авг. 19, 2023
Abstract
Parkinson’s
disease
(PD)
is
the
second
most
common
progressive
neurodegenerative
disorder
associated
with
increased
oxidative
stress,
underlying
vital
process
contributing
to
cell
death.
Tanshinone
IIA
(TAN)
a
phytomedicine
documented
activity
in
treating
many
CNS
disorders,
particularly
PD
owing
its
unique
anti-inflammatory
and
antioxidant
effect.
However,
clinical
utility
limited
by
poor
aqueous
solubility,
short
half-life,
hence
low
concentration
reaching
targeted
cells.
This
work
aimed
develop
biocompatible
chitosan-coated
nanostructured
lipid
carriers
(CS-NLCs)
for
effective
brain
delivery
of
TAN
management.
The
proposed
nanosystem
was
successfully
prepared
using
simple
melt-emulsification
ultra-sonication
method,
optimized
characterized
both
vitro
vivo
rotenone-induced
rat
model.
developed
TAN-loaded
CS-NLCs
(CS-TAN-NLCs)
showed
good
colloidal
properties
(size
≤
200
nm,
PDI
0.2,
ζ-potential
+
20
mV)
high
drug
entrapment
efficiency
(>
97%)
sustained
release
profile
24
h.
Following
intranasal
administration,
CS-TAN-NLCs
succeeded
achieve
remarkable
antiparkinsonian
antidepressant
effect
diseased
animals
compared
uncoated
TAN-NLCs
free
suspension
as
evidenced
conducted
behavioral
tests
improved
histopathological
findings.
Furthermore,
biochemical
evaluation
stress
along
inflammatory
markers,
nuclear
factor-kabba
β
(NF-Kβ)
cathepsin
B
further
confirmed
potential
enhancing
therapeutic
treatment
PD.
Accordingly,
could
be
addressed
promising
nano-platform
management
Graphical
abstract
Journal of Taibah University Medical Sciences,
Год журнала:
2023,
Номер
19(1), С. 35 - 53
Опубликована: Сен. 20, 2023
Psoriasis
is
an
uncontrolled,
long-lasting
inflammatory
dermatosis
distinguished
by
thickened,
erythematous,
and
flaky
skin
lesions.
Massive
amounts
of
cytokines
are
produced
when
immune
system
imbalances
driven
genetic
environmental
triggers.
Vinpocetine
(VNP),
a
man-made
analogue
the
compound
vincamine
found
in
dwarf
periwinkle
herb,
has
robust
anti-inflammatory,
immunomodulatory,
anti-oxidative
effects;
alleviates
epidermal
penetration
cells,
such
as
eosinophils
neutrophils;
abolishes
generation
pro-inflammatory
molecules.
This
study
was
aimed
at
exploring
effects
long-term
topical
VNP,
both
alone
co-administered
with
clobetasol
propionate,
imiquimod-induced
mouse
model
psoriasiform
dermatitis.
The
protocol
consisted
48
Swiss
albino
mice,
randomly
divided
into
six
groups
eight
mice
each.
In
group
I,
petroleum
jelly
administered
daily
for
8
days.
II,
imiquimod
topically
62.5
mg
III,
VI,
V,
0.05%
1%
3%
VNP
plus
were
additional
days
after
induction,
thus
resulting
total
trial
length
16
Topical
various
doses
alleviated
severity
psoriatic
lesions—including
erythema,
silvery-white
scaling,
thickening—and
reversed
histopathological
abnormalities.
Moreover,
imiquimod-exposed
animals
treated
showed
markedly
diminished
concentrations
biomarkers,
including
tumour
necrosis
factor-α,
interleukin
(IL)-8,
IL-17A,
IL-23,
IL-37,
nuclear
factor-kappa
B
(NF-κB),
transforming
growth
factor-β1.
research
provides
new
evidence
that
combination
clobetasol,
may
serve
potential
adjuvant
management
autoimmune
autoinflammatory
diseases,
particularly
psoriasis,
attenuating
lesion
severity,
suppressing
cytokine
generation,
limiting
NF-κB-mediated
inflammation.
Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(19), С. 1683 - 1698
Опубликована: Апрель 27, 2024
:
Alzheimer's
disease
(AD)
is
the
most
prevalent
form
of
neurodegenerative
disorder
(ND),
affecting
more
than
44
million
individuals
globally
as
2023.
It
characterized
by
cognitive
dysfunction
and
an
inability
to
perform
daily
activities.
The
progression
AD
associated
with
accumulation
amyloid
beta
(Aβ),
formation
neurofibrillary
tangles
(NFT),
increased
oxidative
stress,
neuroinflammation,
mitochondrial
dysfunction,
endoplasmic
reticulum
stress.
Presently,
various
phytomedicines
their
bioactive
compounds
have
been
identified
for
neuroprotective
effects
in
reducing
alleviating
mitigating
Aβ
acetylcholinesterase
enzymes
hippocampus
cerebral
cortex
regions
brain.
However,
despite
demonstrating
promising
anti-Alzheimer's
effects,
clinical
utilization
phytoconstituents
remains
limited
scope.
key
factor
contributing
this
limitation
challenges
inherent
traditional
drug
delivery
systems,
which
impede
effectiveness
efficiency.
These
difficulties
encompass
insufficient
targeting,
restricted
solubility
stability,
brief
duration
action,
a
lack
control
over
release.
Consequently,
these
constraints
result
diminished
bioavailability
permeability
across
blood-brain
barrier
(BBB).
In
response
challenges,
novel
systems
(NDDS)
founded
on
nanoformulations
emerged
hopeful
strategy
augment
BBB
poor
solubility.
Among
nanoemulsion
(NE)
extensively
investigated
potential
targeting
AD.
NE
offers
several
advantages,
such
ease
preparation,
high
loading,
stability.
Due
nanosize
droplets,
also
improves
gut
leading
enhanced
systemic
circulation
Various
studies
reported
testing
NE-based
bioactives
different
animal
species,
including
transgenic,
Wistar,
Sprague-Dawley
(SD)
rats,
well
mice.
transgenic
mice
are
commonly
employed
research
analyze
Aβ.
review,
aspects
role
phytoconstituents,
conventional
delivery,
need
NDDS,
particularly
NE,
discussed.
involving
phytoconstituent-based
treatment
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(34), С. 8212 - 8234
Опубликована: Янв. 1, 2024
Aging,
marked
by
dysregulated
cellular
systems,
gives
rise
to
a
spectrum
of
age-related
disorders,
including
neurodegeneration,
atherosclerosis,
immunosenescence,
and
musculoskeletal
issues.
These
conditions
contribute
significantly
the
global
disease
burden,
posing
challenges
health
span
economic
resources.
Current
therapeutic
approaches,
although
diverse
in
mechanism,
often
fall
short
targeting
underlying
pathologies.
They
fail
address
issues
compounded
altered
pharmacokinetics
elderly.
Nanotechnology
emerges
as
transformative
solution,
offering
tissue-specific
targeted
therapies
through
nanoparticles.
Functional
nanomaterials
(FNMs)
respond
internal
or
external
stimuli,
with
light-responsive
gaining
prominence.
Harnessing
benefits
deep
tissue
penetration
ease
manipulation
particularly
near-infrared
spectrum,
FNMs
present
innovative
strategies
for
comorbidities.
This
review
comprehensively
summarizes
potential
FNM-based
approaches
environments
also
emphasizes
advantages
over
traditional
treatment
modalities.
Specifically,
it
focuses
on
development
various
classes
functional
plasmonic
nanomaterials,
carriers,
upconversion
2D
transition
metal
oxide
dichalcogenide
carbon-based
against
age
related
diseases.
We
foresee
that
such
advanced
developments
field
nanotechnology
could
provide
new
hope
clinical
diagnosis
disorders.
