Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106239 - 106239
Опубликована: Сен. 1, 2024
Язык: Английский
Antiviral Research, Год журнала: 2024, Номер 230, С. 105979 - 105979
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122802 - 122802
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2023, Номер 16(9), С. 1323 - 1323
Опубликована: Сен. 19, 2023
Hypertension can begin in childhood; elevated blood pressure children is known as pediatric hypertension. Contrary to adult hypertension, there a scarcity of commercial medications suitable for the treatment The aim this study was develop orally dispersible films (ODFs) loaded with captopril hypertension children. Captopril-loaded ODFs were composed different blends synthetic polymers, such polyvinyl alcohol (PVA) and pyrrolidone, natural sodium alginate (SA) gelatin. characterized based on their mechanical thermal properties, drug content, surface morphology, vitro disintegration, release, bioavailability. A novel HPLC method precolumn derivatization developed precisely selectively determine levels plasma. low concentration PVA high SA generated faster hydration disintegration rates. SA-based exhibited fast properties (1–2 min). optimized modified-release film (F2) showed significant (p < 0.05) enhancement bioavailability (AUC = 1000 ng min/mL), value 1.43 times that Capoten® tablets (701 min/mL). While plasma peaking favor immediate-release tablet, Tmax significantly prolonged by 5.4 ODF (3.59 h) compared (0.66 h). These findings indicate uniform sustained concentrations, opposed pulsatile rapid from tablets. suggest modified release oral could offer more favorable profiles better control than conventional
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2631 - 2631
Опубликована: Ноя. 16, 2023
Among natural sources, guava leaf oil (GLO) has emerged as a potential anticancer agent. However, its limited water solubility poses significant challenge for use. Oil-in-water nanoemulsions are used to address the limitation of GLO prior incorporation into orodipersible films. Nanoemulsions containing GLO:virgin coconut (VCO) at ratio 50:50 70:30 presented small droplet size approximately 50 nm and relatively low zeta potential. GLO:VCO was selected sodium alginate film various concentrations ranging from 1% 30% w/w. Tensile strength elongation break relied on concentration well internal structure Fourier transform infrared spectroscopy revealed that compatible with alginate. Film 2% w/w (2G_ODF) exhibited effective in vitro antioral cancer activity, an IC50 62.49 ± 6.22 mg/mL; furthermore, activity showed no difference after storage 25 °C 1 year. Moreover, 2G_ODF IC60 arrested colony formation cell invasion. There is also evidence death occurred via apoptosis, indicated by nuclear fragmentation positive Annexin-V staining. These findings highlight orodispersible films prospective oral
Язык: Английский
Процитировано
3
Processes, Год журнала: 2023, Номер 11(9), С. 2628 - 2628
Опубликована: Сен. 3, 2023
The interest in buccal drug delivery is under consideration due to some distinct properties compared the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of drug, and substantial compliance special needs patients. Oral films are obtained through various technologies, from conventional tools 3D 4D printing approaches. This minireview aims describe current additive manufacturing technologies film fabrication, display their advantages limitations, discuss formulation strategies. It also provides advanced data regarding synthetic natural polymers used films. Moreover, it shows most recent studies with 3D-printed orodispersible mucoadhesive manufactured previously analyzed methods. Finally, conclusions future perspectives briefly summarized.
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 915 - 915
Опубликована: Июль 9, 2024
Tadalafil (TD) has poor water solubility but is well absorbed without affecting food intake when administered orally. Owing to patient adherence and therapeutic characteristics, a TD-loaded orodispersible film (TDF) preferable. However, the mechanistic role of dietary status on clinical pharmacokinetic analysis TDF in human volunteers should be investigated because gastrointestinal environment varies periodically according meal intervals, although commercial 20 mg tablets (TD-TAB, Cialis® tablet) may taken with or food. was prepared by dispersing TD an aqueous solution polyethylene glycol 400 ensure good dispersibility particles. In fasting state, each T/R Cmax AUC between TD-TAB showed bioequivalence 0.936–1.105 1.012–1.153, respectively, dissolution rates 1000 mL containing 0.5% SLS were equivalent. contrast, not bioequivalent under fed conditions 0.610–0.798. The increased rate via micronization drug particles reduced viscosity second content did significantly affect bioequivalence. Interestingly, increase time from 4 h 6 resulted 0.851–0.998 TDF. predictive diffusion direction model for physical digestion stomach after first successfully simulated using computational fluid dynamics modeling, accounting delayed caused prolonged contents postprandial conditions.
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2024, Номер 17(8), С. 994 - 994
Опубликована: Июль 27, 2024
Rhinacanthins, derived from Rhinacanthus nasutus, widely used in traditional medicine, exhibit antifungal, anticancer, antiviral, antibacterial, and antiplatelet aggregation effects. Recently, their anti-diabetic activity was confirmed, which makes them an interesting natural alternative the therapy of early stage diabetes mellitus. The aim this study to demonstrate possibility formulating orodispersible tablets (ODTs) films (ODFs) containing rhinacanthin-rich extract (RRE). Tablets with 50 mg or 100 RRE were produced by direct compression. ODFs manufactured casting Lycoat RS 720 polyvinyl alcohol solution additional excipients. mechanical properties disintegration times prepared formulations studied. effectiveness taste masking analyzed electronic tongue system. Six months simplified stability studies performed conditions complying ICH guidelines. Appropriate friability ODTs achieved, despite low tensile strength (0.45–0.62 MPa). All successfully met acceptance criteria regarding Young’s modulus, strength, elongation at break. observed variations dependent on type quantity polymers plasticizers used. Disintegration time ranged 38.7 s 54.2 s, while for 24.2 40 pharmacopoeial apparatus. Analyses made showed significant taste-masking effect both formulations. addition sucralose as a sweetener menthol mint flavor agent sufficient mask RRE’s case ODFs. Stability packed PVC/Alu blisters decrease content below 90% after 6 months. However, PVA physicochemically stable being stored Alu/Alu sachets. Our proved first formulation dosage forms RRE, characterized good properties, time, appropriate masking.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106239 - 106239
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0