Research progress in brain-targeted nasal drug delivery

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 15

Опубликована: Янв. 17, 2024

The unique anatomical and physiological connections between the nasal cavity brain provide a pathway for bypassing blood–brain barrier to allow direct brain-targeted drug delivery through administration. There are several advantages of administration compared with other routes; example, first-pass effect that leads metabolism orally administered drugs can be bypassed, poor compliance associated injections minimized. Nasal also help maximize delivery, allowing high pharmacological activity at lower dosages, thereby minimizing likelihood adverse effects providing highly promising treatment central nervous system diseases. aim this review article was briefly describe structures brain, pathways which enter nose, factors affecting methods improve systems application related biomaterials, common experimental used in intranasal research, current limitations such approaches, solid foundation further in-depth research on (see Graphical Abstract ).

Язык: Английский

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Green extraction of essential oils from Pistacia lentiscus resins: Encapsulation into Niosomes showed improved preferential cytotoxic and apoptotic effects against breast and ovarian cancer cells

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 87, С. 104820 - 104820

Опубликована: Авг. 4, 2023

The essential oils extracted from Pistacia lentiscus resins possess promising antiproliferative effects against ovarian and breast cancer cells because of their high content bioactive compounds. However, PO has many drawbacks that hinder its application in therapy, such as increased volatility, hydrophobicity, limited bioavailability. In this study, niosomal formulation loaded with oil (PO) was formulated improved stability cytotoxicity two cell lines. regard, the Chios mastic utilizing a green approach, hydrodistillation. Its chemical composition analyzed using gas-chromatography–mass spectrometry. loaded-niosomes (PO/Ns) were prepared thin-film hydration method. nanovesicles spherical had an average size 230.3 ± 3.7 nm, polydispersity index 0.13 0.03, ζ potential (ZP) −20.36 4.89 mV. PO/Ns entrapment efficiency (EE) 80.59 3.37% displayed sustained release manner (83.74 3.34%) over 72 h. Moreover, developed exhibited outstanding terms size, PDI, ZP, EE% when stored for 21 days. SRB assay showed IC50 values (Skov-3) (MCF-7) lines 57.04 to 69.1 μg/mL 4.88 7.38 μg/mL, respectively, encapsulated niosomes (PO/Ns). Loading by 10-folds Skov-3 MCF-7 cells. On other hand, safety both evident computed >200 normal epithelial line (MCF10A). enhanced apoptotic (combined early late apoptosis) 9-fold 4-fold cells, compared unloaded treatment. Cell cycle analysis revealed mainly targets sub-G1 phase, where it traps providing further evidence induction apoptosis SKOV-3 Real-time PCR (RT-qPCR) performed quantify gene expression pro-apoptotic markers Bak Bax, well antiapoptotic marker Bcl-2 upon exposure treatments. Both demonstrated remarkable ability upregulate downregulate Bcl-2. As expected, upregulation genes mitochondrial death significantly higher than pure treatment among investigated (Skov-3 MCF-7). Essential into significant cytotoxic

Язык: Английский

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Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Pharmaceutics, Год журнала: 2023, Номер 16(1), С. 58 - 58

Опубликована: Дек. 29, 2023

Alzheimer's disease, a progressive neurodegenerative condition, is characterized by gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal routes, aiming to improve function alleviate symptoms. However, these treatments face limitations, such as low bioavailability inadequate permeation. Alternative invasive methods, while explored, often entail discomfort require specialized assistance. Therefore, development non-invasive efficient delivery system crucial. Intranasal has emerged potential solution, although it constrained unique conditions nasal cavity. An innovative approach involves use nano-carriers based on nanotechnology for intranasal delivery. This strategy overcome current limitations providing enhanced bioavailability, improved permeation, effective traversal blood-brain barrier, extended retention within body, precise targeting brain. The comprehensive review focuses advancements designing various types nano-carriers, including polymeric nanoparticles, metal lipid liposomes, nanoemulsions, Quantum dots, dendrimers. These are specifically tailored therapeutic agents aimed at combatting disease. In summary, utilization systems show significant surmounting constraints disease strategies. Nevertheless, essential acknowledge regulatory well toxicity concerns associated with this route; meticulous consideration required when engineering carrier. underscores revolutionize management highlights importance addressing considerations safe implementations. Embracing could lead substantial field treatment.

Язык: Английский

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Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

Gels, Год журнала: 2024, Номер 10(1), С. 45 - 45

Опубликована: Янв. 6, 2024

Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, patient noncompliance. To tackle these novel topical platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding development of nanoemulgels for application, encapsulating wide variety molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), wound healing, appendage infections, inflammatory diseases, cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, release, permeation and/or retention capacity, having more characteristics than current formulations. In vitro in vivo studies established efficacy developed formulations, confirming their potential, making them promising replacement therapies, as possible adjuvant treatments, which might someday effectively reach market help fight highly incident systemic conditions.

Язык: Английский

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Recent developments in intranasal drug delivery of nanomedicines for the treatment of neuropsychiatric disorders

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 19, 2024

Neuropsychiatric disorders are multifaceted syndromes with confounding neurological explanations. It includes anxiety, depression, autism spectrum disorder, attention deficit hyperactivity schizophrenia, Tourette’s syndrome, delirium, dementia, vascular cognitive impairment, and apathy etc. Globally, these occupy 15% of all diseases. As per the WHO, India has one largest populations people mental illnesses worldwide. The blood-brain barrier (BBB) makes it extremely difficult to distribute medicine target cells in brain tissues. However, is possible through novel advancements nanotechnology, molecular biology, neurosciences. One such cutting-edge delivery method, nose-to-brain (N2B) drug using nanoformulation (NF), overcomes traditional formulation limitations. Later offers more controlled release, better bioavailability, improved patient acceptance, reduced biological interference, circumvention BBB. When medicines delivered via intranasal (IN) route, they enter nasal cavity go connections between olfactory trigeminal nerves mucosa N2B. Delivering phytochemical, bioactive synthetic NF being investigated N2B strategy. mucociliary clearance, enzyme degradation, translocations by efflux mechanisms significant issues associated delivery. This review article discusses types neuropsychiatric their treatment plant-derived as well drug-loaded NFs administered IN-delivery system. In conclusion, this provided a comprehensive critical overview IN applicability for psychiatric disorders.

Язык: Английский

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Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 998 - 998

Опубликована: Март 20, 2023

Depression and anxiety are high incidence debilitating psychiatric disorders, usually treated by antidepressant or anxiolytic drug administration, respectively. Nevertheless, treatment is given through the oral route, but low permeability of blood–brain barrier reduces amount that will be able to reach it, thus consequently reducing therapeutic efficacy. Which why it imperative find new solutions make these treatments more effective, safer, faster. To overcome this obstacle, three main strategies have been used improve brain targeting: intranasal route which allows directly transported neuronal pathways, bypassing avoiding hepatic gastrointestinal metabolism; use nanosystems for encapsulation, including polymeric lipidic nanoparticles, nanometric emulsions, nanogels; molecule functionalization ligand attachment, such as peptides polymers. Pharmacokinetic pharmacodynamic in vivo studies’ results shown administration can efficient targeting than other routes, nanoformulations quite advantageous increasing brain–drug bioavailability. These could key future improved therapies depressive disorders.

Язык: Английский

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Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Russian Journal of General Chemistry, Год журнала: 2023, Номер 93(7), С. 1867 - 1899

Опубликована: Июль 1, 2023

Abstract The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving solubility of hydrophobic bioactives. Further, liposomal vehicles reviewed, both advantages limitations discussed. Literature assay covers up-to-date information about last three five years, although brief background is given pioneer works addressing liposomes their evolution from bench bedside. Final part devoted modern modifications vesicular nanocarriers which can be adapted specific administration way due improved targeting properties, permeability, mucoadhesiveness possibility cross biological barriers. Therein, such kinds transfersomes, niosomes, ethosomes, chitosomes evaluated; separate sections focus formulations, i.e., phytosomes invasomes.

Язык: Английский

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Preclinical Evaluation on Human Platelet Lysate for the Treatment of Secondary Injury Following Intracerebral Hemorrhage

Brain Research Bulletin, Год журнала: 2024, Номер 220, С. 111153 - 111153

Опубликована: Ноя. 29, 2024

Язык: Английский

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Fluidized spanlastics for intranasal brain delivery of lacosamide aiming to control status epilepticus: Design, Characterization, Ex-vivo permeation, Radioiodination and In-vivo biodistribution studies

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 101, С. 106173 - 106173

Опубликована: Сен. 12, 2024

Язык: Английский

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Research Progress on Liposome Pulmonary Delivery of Mycobacterium tuberculosis Nucleic Acid Vaccine and Its Mechanism of Action

Journal of Aerosol Medicine and Pulmonary Drug Delivery, Год журнала: 2024, Номер 37(5), С. 284 - 298

Опубликована: Апрель 26, 2024

Traditional vaccines have played an important role in the prevention and treatment of infectious diseases, but they still problems such as low immunogenicity, poor stability, difficulty inducing lasting immune responses. In recent years, nucleic acid vaccine has emerged a relatively cheap safe new vaccine. Compared with traditional vaccines, some unique advantages, easy production storage, scalability, consistency between batches. However, direct administration naked is not ideal, safer more effective delivery systems are needed. With rapid development nanocarrier technology, combination gene therapy nanodelivery broadened therapeutic application molecular biology medical biological nanomaterials. Nanoparticles can be used potential drug-delivery vehicles for hereditary diseases. addition, due to advantages lung immunity, onset action, good efficacy, reduced adverse reactions, pulmonary become hot spot field research. lipid nanocarriers safe, efficient, ideal materials their physical chemical properties, which effectively reduce toxic side effects drugs achieve effect slow release controlled release, there been large number studies using efficiently deliver target components into body. Based on tuberculosis (TB) by carrier, this article systematically reviews mechanism liposomes so lay solid foundation faster anti-TB future.

Язык: Английский

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