Molecules,
Год журнала:
2024,
Номер
29(3), С. 678 - 678
Опубликована: Фев. 1, 2024
The
fusion
of
penetrating
peptides
(PPs),
e.g.,
cell
penetration
(CPPs)
or
antimicrobial
(AMPs),
together
with
agents
is
an
expanding
research
field.
Specific
AMPs,
such
as
lactoferricin
B
(LfcinB),
have
demonstrated
strong
antibacterial,
antifungal,
and
antiparasitic
activity,
well
valuable
anticancer
proving
beneficial
in
the
development
conjugates.
resulting
conjugates
offer
potential
dual
functionality,
acting
both
agent.
This
especially
necessary
cancer
treatment,
where
microbial
infections
pose
a
critical
risk.
Leukemic
cells
frequently
exhibit
altered
outer
lipid
membranes
compared
to
healthy
cells,
making
them
more
sensitive
compounds
that
interfere
their
membrane.
In
this
study,
we
revisited
reanalyzed
our
earlier
on
LfcinB
its
Furthermore,
carried
out
new
experiments
specific
focus
proliferation,
changes
membrane
asymmetric
phosphatidylserine
location,
intracellular
reactive
oxygen
species
(ROS)
generation,
mitochondrial
functions,
vitro
bacterial
topoisomerase
inhibition.
International Journal of Food Science & Technology,
Год журнала:
2025,
Номер
60(1)
Опубликована: Янв. 1, 2025
Abstract
The
study
was
conducted
to
analyze
the
antimicrobial
activity
and
sensitivity
of
bovine
lactoferrin
against
foodborne
pathogens
evaluate
pH
range
thermal
stability
lactoferrin.
agar
well
diffusion
test
used
check
each
pathogen.
Bacterial
samples
were
purified
confirmed
by
biochemical
tests.
Three
concentrations
0.5,
1,
10
mg/ml
evaluated
for
antibacterial
Escherichia
coli,
Salmonella
enteritidis,
Staphylococcus
aureus.
Our
results
indicated
that
all
three
pathogenic
bacteria
inhibited,
even
at
0.5
(p
<
.05).
E.
coli
most
sensitive,
S.
aureus
least
sensitive.
Lactoferrin
remains
effective
6,
7,
8,
9
pH,
but
no
inhibition
showed
3,
4,
5
change
a
pasteurization
temperature
60–75
°C
.05)
inactivated
higher
temperatures.
can
inhibit
from
growth
remain
unchanged
ranges
6–9.
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(14)
Опубликована: Март 29, 2024
Tumor
necrosis
factor
(TNF)
receptor
1
(TNFR1)
plays
a
pivotal
role
in
mediating
TNF
induced
downstream
signaling
and
regulating
inflammatory
response.
Recent
studies
have
suggested
that
TNFR1
activation
involves
conformational
rearrangements
of
preligand
assembled
dimers
targeting
dynamics
is
viable
strategy
to
modulate
signaling.
Here,
we
used
combination
biophysical,
biochemical,
cellular
assays,
as
well
molecular
simulation
show
an
anti-inflammatory
peptide
(FKCRRWQWRMKK),
which
termed
FKC,
inhibits
allosterically
by
altering
the
states
dimer
without
blocking
receptor–ligand
interaction
or
disrupting
dimerization.
We
also
demonstrated
efficacy
FKC
showing
HEK293
cells
attenuates
inflammation
mice
with
intraperitoneal
injection.
Mechanistically,
found
binds
cysteine-rich
domains
(CRD2/3)
perturbs
required
for
activation.
Importantly,
increases
frequency
opening
both
CRD2/3
CRD4
dimer,
induces
cytosolic
regions
receptor.
This
results
inhibitory
state
impedes
recruitment
molecules.
Together,
these
data
provide
evidence
on
feasibility
conformationally
active
region
open
new
avenues
receptor-specific
inhibition
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 15, 2024
Emerging
infectious
diseases
are
caused
by
unpredictable
viruses
with
the
dangerous
potential
to
trigger
global
pandemics.
These
typically
initiate
infection
utilizing
anionic
structures
of
host
cell
surface
receptors
gain
entry.
Lactoferrin
(Lf)
is
a
multifunctional
glycoprotein
multiple
properties
such
as
antiviral,
anti-inflammatory
and
antioxidant
activities.
Due
its
cationic
structure,
Lf
naturally
interacts
certain
receptors,
heparan
sulfate
proteoglycans,
well
viral
particles
other
that
targeted
viruses.
Therefore,
may
interfere
virus-host
interactions
acting
receptor
competitor
for
Herein
we
summarize
studies
in
which
this
competition
was
investigated
SARS-CoV-2,
Zika,
Dengue,
Hepatitis
Influenza
vitro
.
have
demonstrated
not
only
Lf’s
competitive
properties,
but
also
intracellular
impact
on
cells,
enhancing
survival
reducing
efficiency
inhibiting
enzymes.
In
addition,
immunomodulatory
effect
highlighted,
it
can
influence
activity
specific
immune
cells
regulate
cytokine
release,
thereby
host’s
response
infections.
Collectively,
these
promote
promising
candidate
research
diseases.
Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426,
Год журнала:
2025,
Номер
8(1), С. 11 - 30
Опубликована: Янв. 18, 2025
Plants
and
organic
foods
inherently
contain
bioactive
compounds
that
combat
oxidative
stress
effectively.
A
pharmacological
overview
of
the
activity
action
active
against
X-ray
damage
is
provided,
along
with
a
review
chemistry,
functionality,
application
aspects
derived
from
natural
sources
may
mitigate
harmful
effects
radiation
shield
biological
systems
stress.
The
findings
revealed
antioxidants
such
as
(lactoferrin,
curcumin,
melatonin,
phycocyanin,
saponin)
phenolic
in
plant
extracts
could
be
preventive
therapeutic
agents
X-ray-induced
toxicity.
Natural
function
protectants,
mitigating
induced
by
exposure.
Given
non-toxic
nature
examined
this
study,
we
suggest
using
them
to
produce
nutraceutical
beverage
can
consumed
or
included
daily
diet
minimize
Keywords:
Active
compounds,
Antioxidant
enzymes,
Lactoferrin,
Oxidative
stress,
Saponin,
Watermelon
juice
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 938 - 938
Опубликована: Март 7, 2025
Whey
is
a
natural
by-product
of
the
cheese-making
process
and
represents
valuable
source
nutrients,
including
vitamins,
all
essential
amino
acids
proteins
with
high
quality
digestibility
characteristics.
Thanks
to
its
different
techno-functional
characteristics,
such
as
solubility,
emulsification,
gelling
foaming,
it
has
been
widely
exploited
in
food
manufacturing.
Also,
advances
processing
technologies
have
enabled
industrial
production
variety
whey-based
products
exerting
biological
activities.
The
beneficial
properties
whey
(WPs)
include
their
documented
effects
on
cardiovascular,
digestive,
endocrine,
immune
nervous
systems,
putative
role
prevention
treatment
non-communicable
diseases
(NCDs).
In
this
regard,
research
application
for
health
enhancement,
based
optimization
product
formulation
development
pharmaceuticals,
highly
relevant.
Beyond
nutritionally
relevant
vivo
animal
studies,
allergenicity
WPs
WP
hydrolysates
also
herein
tackled
discussed,
well
potential
therapeutics
tolerance
so-called
tolerogenic
effects.
Grounded
WPs’
health-promoting
functions,
paper
presents
latest
showing
whey-derived
peptides
an
alternative
strategy
NCD
treatment.
This
work
reports
careful
analysis
current
use,
revealing
which
obstacles
limit
full
exploitation,
thus
highlighting
future
challenges
field.
Concluding,
safety
considerations,
encompassing
allergenicity,
are
providing
some
insights
milk
allergen
immunotolerance.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Lactoferrin
(LF),
a
multifunctional
glycoprotein
with
high
iron-binding
affinity,
plays
critical
role
in
modulating
physiological
processes
through
its
ability
to
reversibly
bind
and
release
iron
ions,
existing
two
distinct
states:
iron-saturated
(holo-LF,
>
85%
saturation)
iron-deficient
(apo-LF,
<
5%
saturation).
However,
the
importance
of
saturation
has
been
largely
overlooked
LF
production
research
due
lack
standardized
protocols.
The
level
dictates
functional
specificity:
apo-LF
exhibits
potent
antimicrobial
properties
by
chelating
disrupting
membrane
integrity,
while
also
significantly
inhibiting
oxidative
stress,
thereby
alleviating
neurological
disorders
immune
responses.
In
contrast,
holo-LF
participates
metabolism
transport,
influencing
tumor
cell
proliferation
systemic
uptake.
This
review
systematically
evaluates
interplay
between
levels
LF's
biological
functions,
emphasizing
dual
roles
human
homeostasis
disease
modulation.
Future
should
prioritize
elucidating
mechanisms
underlying
saturation-dependent
bioactivity
metabolic
differences,
incorporating
emerging
technologies
enhance
stability
refine
measurement
accuracy.
