According
to
the
International
Union
of
Pure
and
Applied
Chemistry
(IUPAC),
peptides
are
small
proteins
with
a
size
between
2
50
amino
acids
residues.
They
ubiquitous
across
evolutionary
scale,
fulfilling
wide
variety
functions,
from
immune
system
effectors
in
simple
organisms
signaling
or
neuromodulating
agents
high
vertebrates.
Following
nature’s
example,
have
emerged
as
alternatives
various
fields.
One
particularly
relevant
area
is
drug
discovery,
offering
face
emergence
antibiotic-resistant
microorganisms.
Peptides
also
prevalent
other
sectors,
such
food
industry,
where
they
serve
additives
enhance
nutritional
characteristics
aid
preservation.
Moreover,
increasingly
being
utilized
cosmetics.
Additionally,
valuable
tools
both
basic
applied
research,
facilitating
exploration
specific
activity
mechanisms
verification
particular
activities,
among
applications.
Despite
certain
limitations
disadvantages
compared
bioactive
molecules,
remain
focal
point
interest
well
developmental
fields,
due
their
versatility.
In
this
report,
we
provide
an
overview
extensive
application
landscape
synthetic
peptides,
presenting
examples
developed
in-house
different
areas
which
include
summary
methodologies
results
obtained.
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
211, С. 115354 - 115354
Опубликована: Июнь 12, 2024
One
of
the
key
aspects
coping
efficiently
with
complex
pathological
conditions
is
delivering
desired
therapeutic
compounds
precision
in
both
space
and
time.
Therefore,
focus
on
nuclear-targeted
delivery
systems
has
emerged
as
a
promising
strategy
high
potential,
particularly
gene
therapy
cancer
treatment.
Here,
we
explore
design
supramolecular
nanoassemblies
vehicles
to
deliver
specific
nucleus,
special
polymer
peptide-based
carriers
that
expose
nuclear
localization
signals.
Such
aim
at
maximizing
concentration
genetic
agents
within
thereby
optimizing
treatment
outcomes
while
minimizing
off-target
effects.
A
scenario
conditions,
including
cellular
uptake,
endosomal
escape,
translocation,
requires
fine
tuning
nanocarriers'
properties.
First,
introduce
principles
import
role
pore
complexes
reveal
strategies
for
targeting
nanosystems
nucleus.
Then,
provide
an
overview
cargoes
rely
optimal
activity
their
integrity
accumulation
are
crucial
parameters
consider
when
designing
suitable
system.
Considering
they
early
stages
research,
present
various
cargo-loaded
peptide-
promote
targeting,
emphasizing
potential
enhance
response.
Finally,
briefly
discuss
further
advancements
more
precise
effective
delivery.
Systemic
delivery
of
large
nucleic
acids,
such
as
mRNA,
to
the
brain
remains
challenging
in
part
due
blood-brain
barrier
(BBB)
and
tendency
vehicles
accumulate
liver.
Here,
we
design
a
peptide-functionalized
lipid
nanoparticle
(LNP)
platform
for
targeted
mRNA
brain.
We
utilize
click
chemistry
functionalize
LNPs
with
peptides
that
target
receptors
overexpressed
on
endothelial
cells
neurons,
namely
RVG29,
T7,
AP2,
mApoE
peptides.
evaluate
effect
LNP
targeting
neuronal
cell
transfection
vitro,
investigating
factors
serum
protein
adsorption,
intracellular
trafficking,
transcytosis,
exosome
secretion.
Finally,
show
peptide
functionalization
enhances
mouse
reduces
hepatic
after
systemic
administration.
Specifically,
RVG29
improved
vivo,
establishing
its
potential
nonviral
delivering
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 27, 2023
With
the
deepening
of
our
understanding
adaptive
immunity
at
cellular
and
molecular
level,
targeting
antigens
directly
to
immune
cells
has
proven
be
a
successful
strategy
develop
innovative
potent
vaccines.
Indeed,
it
offers
potential
increase
vaccine
potency
and/or
modulate
response
quality
while
reducing
off-target
effects.
mRNA-vaccines
establishing
themselves
as
versatile
technology
for
future
applications,
in
last
years
several
approaches
have
been
explored
target
nanoparticles-enabled
mRNA-delivery
systems
cells,
with
focus
on
dendritic
cells.
Dendritic
(DCs)
are
most
antigen
presenting
key
mediators
B-
T-cell
immunity,
therefore
considered
an
ideal
cell-specific
delivery.
improved
DC-targeted
vaccines
proved
vitro
vivo
.
This
review
discusses
specific
targets
system-directed
mRNA
delivery,
well
different
ligand
classes
delivery
used
this
purpose.
Frontiers in Drug Delivery,
Год журнала:
2024,
Номер
4
Опубликована: Фев. 1, 2024
Ovarian
cancers
are
a
complex
and
heterogenic
group
of
malignancies
that
difficult
to
detect,
diagnose
treat.
Fortunately,
considerable
knowledge
ovarian
cancer
specific
biomarkers
has
been
generated,
is
pertinent
the
development
novel
theranostic
platforms
by
combining
therapies
diagnostics.
Genomic
proteomic
data
invaluable
in
providing
critical
biomolecular
targets
for
approaches.
Exploitation
wealth
biomarker
research
conducted
offers
viable
as
beacons
detection,
diagnosis,
therapeutic
targeting.
These
markers
can
be
used
theranostics,
treatment
strategy
combines
therapy
diagnostics
common
nuclear
medicine,
where
radionuclides
both
diagnosis
treatment.
The
theranostics
taken
substantial
focus
recent
years
battle
against
cancer.
Yet
date
only
one
technology
emerged
clinical
practice.
However,
given
field
poised
see
emergence
revolutionary
disease
monitoring
outcomes
through
their
incorporation
into
strategies.
future
set
enable
precise
targeted
treatment,
vigilant
monitoring.
This
review
aims
assess
status
diagnostic
tools
practice,
development,
or
pre-clinical
highlighting
newly
emerging
applications.
Journal of Biomedical Science,
Год журнала:
2024,
Номер
31(1)
Опубликована: Апрель 19, 2024
Abstract
Sepsis
represents
a
critical
medical
condition
stemming
from
an
imbalanced
host
immune
response
to
infections,
which
is
linked
significant
burden
of
disease.
Despite
substantial
efforts
in
laboratory
and
clinical
research,
sepsis
remains
prominent
contributor
mortality
worldwide.
Nanotechnology
presents
innovative
opportunities
for
the
advancement
diagnosis
treatment.
Due
their
unique
properties,
including
diversity,
ease
synthesis,
biocompatibility,
high
specificity,
excellent
pharmacological
efficacy,
peptides
hold
great
potential
as
part
nanotechnology
approaches
against
sepsis.
Herein,
we
present
comprehensive
up-to-date
review
applications
nanosystems
combating
sepsis,
with
expedite
enhance
management
outcomes.
Firstly,
pathophysiology,
antisepsis
drug
targets,
current
modalities
limitations,
advance
have
been
adequately
addressed.
The
organized
into
diagnostic
or
managing
applications,
last
one
being
further
sub-organized
nano-delivered
bioactive
antimicrobial
anti-inflammatory
activity,
targeting
moieties
on
surface
nanocarriers
agents.
studies
grouped
thematically
discussed,
emphasizing
constructed
nanosystem,
physicochemical
peptide-imparted
enhancement
therapeutic
efficacy.
strengths,
research
gaps
each
section
elaborated.
Finally,
challenges
future
paths
use
deliberately
spotlighted.
This
reaffirms
peptides'
promising
biomaterials
within
strategies
aimed
at
improving
management.
Graphical
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(5), С. 713 - 734
Опубликована: Май 3, 2024
Introduction
Polymer
nanogels
are
among
the
most
promising
nanoplatforms
for
use
in
biomedical
applications.
The
substantial
interest
these
drug
carriers
is
to
enhance
transportation
of
bioactive
substances,
reduce
side
effects,
and
achieve
optimal
action
on
curative
sites
by
targeting
delivery
triggering
release
drugs
a
controlled
continuous
mode.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 29, 2025
The
immunopeptidome,
a
diverse
set
of
peptides
presented
by
Major
Histocompatibility
Complex
(MHC)
molecules,
is
critical
component
immune
recognition
and
response.
This
review
article
delves
into
the
mechanisms
peptide
presentation
MHC
particularly
emphasizing
roles
ncRNA-derived
extracellular
vesicles
(EVs)
in
shaping
immunopeptidome
landscape.
We
explore
established
emerging
insights
molecule
interactions
with
peptides,
including
dynamics
loading,
transport,
influence
cellular
genetic
variations.
highlights
novel
research
on
non-coding
RNA
(ncRNA)-derived
which
challenge
conventional
views
antigen
processing
role
EVs
transporting
these
thereby
modulating
responses
at
remote
body
sites.
not
only
challenges
but
also
opens
up
new
avenues
for
understanding
responses.
Furthermore,
we
discuss
implications
developing
therapeutic
strategies,
cancer
immunotherapy.
By
conducting
comprehensive
analysis
current
literature
advanced
methodologies
immunopeptidomics,
this
aims
to
deepen
complex
interplay
between
system,
offering
perspectives
potential
diagnostic
applications.
Additionally,
provide
mechanism
enhanced
surface
highlight
pathway
their
systemic
distribution,
potentially
altering
surveillance
landscapes.
