According
to
the
International
Union
of
Pure
and
Applied
Chemistry
(IUPAC),
peptides
are
small
proteins
with
a
size
between
2
50
amino
acids
residues.
They
ubiquitous
across
evolutionary
scale,
fulfilling
wide
variety
functions,
from
immune
system
effectors
in
simple
organisms
signaling
or
neuromodulating
agents
high
vertebrates.
Following
nature’s
example,
have
emerged
as
alternatives
various
fields.
One
particularly
relevant
area
is
drug
discovery,
offering
face
emergence
antibiotic-resistant
microorganisms.
Peptides
also
prevalent
other
sectors,
such
food
industry,
where
they
serve
additives
enhance
nutritional
characteristics
aid
preservation.
Moreover,
increasingly
being
utilized
cosmetics.
Additionally,
valuable
tools
both
basic
applied
research,
facilitating
exploration
specific
activity
mechanisms
verification
particular
activities,
among
applications.
Despite
certain
limitations
disadvantages
compared
bioactive
molecules,
remain
focal
point
interest
well
developmental
fields,
due
their
versatility.
In
this
report,
we
provide
an
overview
extensive
application
landscape
synthetic
peptides,
presenting
examples
developed
in-house
different
areas
which
include
summary
methodologies
results
obtained.
European Polymer Journal,
Год журнала:
2024,
Номер
219, С. 113386 - 113386
Опубликована: Авг. 14, 2024
Intracellular
targets.
(A)
simplified
illustration
of
a
typical
mammalian
cells
with
list
classes
intracellular
"druggable"
molecules.
The
increasing
popularity
peptides
and
proteins
targeted
therapeutics
is
primarily
attributed
to
their
inherent
advantages,
such
as
precise
targeting
the
reduction
side
effects,
compared
traditional
nonspecific
small
molecular
drugs.
In
recent
times,
another
achievement
in
peptide-based
identified
potential
target
protein–protein
interactions
(PPI)
deemed
previously
"undruggable".
As
matter
fact,
precision
PPI
newfound
hope
for
large
number
conditions
which
had
no
treatment.
review
explores
strategies
by
molecules,
mode
activity
biological
system,
transport
mechanisms
involved,
common
barriers
that
need
be
overcome.
It
also
discusses
challenges
lab
clinic
translation
focusing
on
delivery
peptides.
According
to
the
International
Union
of
Pure
and
Applied
Chemistry
(IUPAC),
peptides
are
small
proteins
with
a
size
between
2
50
amino
acids
residues.
They
ubiquitous
across
evolutionary
scale,
fulfilling
wide
variety
functions,
from
immune
system
effectors
in
simple
organisms
signaling
or
neuromodulating
agents
high
vertebrates.
Following
nature’s
example,
have
emerged
as
alternatives
various
fields.
One
particularly
relevant
area
is
drug
discovery,
offering
face
emergence
antibiotic-resistant
microorganisms.
Peptides
also
prevalent
other
sectors,
such
food
industry,
where
they
serve
additives
enhance
nutritional
characteristics
aid
preservation.
Moreover,
increasingly
being
utilized
cosmetics.
Additionally,
valuable
tools
both
basic
applied
research,
facilitating
exploration
specific
activity
mechanisms
verification
particular
activities,
among
applications.
Despite
certain
limitations
disadvantages
compared
bioactive
molecules,
remain
focal
point
interest
well
developmental
fields,
due
their
versatility.
In
this
report,
we
provide
an
overview
extensive
application
landscape
synthetic
peptides,
presenting
examples
developed
in-house
different
areas
which
include
summary
methodologies
results
obtained.
