International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 17099 - 17099
Опубликована: Дек. 4, 2023
In recent years, significant progress has been made in the design and development of biopolymer-based delivery systems for a wide range applications, including cancer therapy, gene editing, regenerative medicine, vaccine [...].
Язык: Английский
Gels, Год журнала: 2024, Номер 10(1), С. 43 - 43
Опубликована: Янв. 5, 2024
The care and rehabilitation of acute chronic wounds have a significant social economic impact on patients global health. This burden is primarily due to the adverse effects infections, prolonged recovery, associated treatment costs. Chronic can be treated with variety approaches, which include surgery, negative pressure wound therapy, dressings, hyperbaric oxygen therapy. However, each these strategies has an array limitations. existing dry dressings lack functionality in promoting healing exacerbating pain by adhering wound. Hydrogels, are commonly polymer-based swell water, been proposed as potential remedies their ability provide moist environment that facilitates healing. Their unique composition enables them absorb exudates, exhibit shape adaptability, modified incorporate active compounds such growth factors antibacterial compounds. review provides updated discussion leading natural synthetic hydrogels utilized healing, details latest advancements hydrogel technology, explores alternate approaches this field. Search engines Scopus, PubMed, Science Direct, Web were advances applications over last fifteen years.
Язык: Английский
Процитировано
64
Processes, Год журнала: 2023, Номер 11(9), С. 2696 - 2696
Опубликована: Сен. 8, 2023
Biomaterials are mostly any natural and synthetic materials which compatible from a biological point of view with the human body. widely used to sustain, increase, reestablish or substitute function injured tissue organ Additionally, biomaterials uninterruptedly in contact body, i.e., tissue, blood fluids. For this reason, an essential feature is their biocompatibility. Consequently, review summarizes classification different types based on origin, as ones. Moreover, advanced applications pharmaceutical medical domains highlighted specific mechanical physical properties biomaterials, concerning use. The high-priority challenges field also discussed, especially those regarding transfer implementation valuable scientific results practice.
Язык: Английский
Процитировано
30
Polymers, Год журнала: 2024, Номер 16(10), С. 1399 - 1399
Опубликована: Май 14, 2024
In this work, biopolymer chitosan and natural clay were used to obtain composite materials. The overall aim of study was improve the properties (porosity, thermal stability density) pure beads by addition a chitosan-based material for adsorption heavy metals from an aqueous solution, using Mongolian resources, mechanism. pre-treated with acid heat remove impurities. mixed in different ratios (8:1, 8:2 8:3) chemical processing bead chromium ions. Cr(III) Cr(VI) studied as function solution pH, time, temperature, initial concentration mass bead. It found that obtained mixture treated ratio 8:1 had highest capacity (23.5 17.31 mg·g−1) Cr(VI), respectively, optimum conditions. materials, prepared mixing 8:2, investigated XRD, SEM–EDS, BET TG analysis. mechanism discussed based on XPS analysis results. confirmed ions adsorbed their original form, such without undergoing oxidation or reduction reactions. Furthermore, associated hydroxyl amino groups during adsorption. kinetic, thermodynamic isothermal process revealed interaction between chitosan/clay can be considered second-order endothermic reaction, assessed Langmuir isotherm model. concluded could adsorbent removal
Язык: Английский
Процитировано
10
Materials, Год журнала: 2024, Номер 17(14), С. 3472 - 3472
Опубликована: Июль 13, 2024
Nerve injury can significantly impair motor, sensory, and autonomic functions. Understanding nerve degeneration, particularly Wallerian the mechanisms of regeneration is crucial for developing effective treatments. This manuscript reviews use advanced hydrogels that have been researched to enhance regeneration. Hydrogels, due their biocompatibility, tunable properties, ability create a supportive microenvironment, are being explored effectiveness in repair. Various types hydrogels, such as chitosan-, alginate-, collagen-, hyaluronic acid-, peptide-based discussed roles promoting axonal growth, functional recovery, myelination. Advanced formulations incorporating growth factors, bioactive molecules, stem cells show significant promise overcoming limitations traditional therapies. Despite these advancements, challenges achieving robust reliable remain, necessitating ongoing research optimize hydrogel-based interventions neural
Язык: Английский
Процитировано
6
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(1)
Опубликована: Янв. 1, 2025
ABSTRACT Tissue engineering is a vast expanding field with applications in areas such as tissue/organ transplantation, drug delivery, vitro models, and so on. Biomaterials form an essential component tissue by acting template for cellular activity, therefore, novel tissue‐engineered biomaterials innovative properties are high demand. Hence, this work proposes interpenetrating polymer network cryogel of chitosan hydroxyethyl methacrylate (HEMA) biomaterial uniform cell seeding throughout the matrix. The physical analysis cryogels demonstrated highly macroporous structure exhibiting pore size distribution overall porosity through emission‐scanning electron microscopy (FE‐SEM) sizes lying range 50–200 μm 150–400 horizontal transverse plane, respectively. were also found to be degradable average percent degradation 17.28 ± 1.47% 4 weeks, their mechanical revealed compressive strength 0.05 MPa elastic modulus 3 MPa. Further, biological characterization direct contact test depicted excellent biocompatibility L929 mouse fibroblast MC3T3‐E1 preosteoblasts negligible presence dead cells around cryogel. Uniform increasing proliferation trend was observed on these live‐dead staining MTT assay at day 1, 3, 7‐time point. Cell adherence studies via FE‐SEM similar along flattened morphology extracellular matrix production. Therefore, based promising physico‐chemical properties, HEMA‐Chitosan exhibit strong potential application engineered biomaterials.
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214214 - 214214
Опубликована: Янв. 1, 2025
Managing wounds in certain phases of the healing process still represents a big challenge. The oxidative stress, caused by reactive oxygen species (ROS), is one hallmarks controlling wound healing-related process. Multifunctional biomaterials with excellent biocompatibility, tuneable properties, and easy functionalization, may allow realizing suitable three-dimensional (3D) extracellular matrix (ECM)-mimicking structures, to efficiently control ROS levels. This might be promising strategy for severe wounds. Herein, photo-crosslinkable methacrylated gelatin (GelMA)-based spongy-like cryogels (from 5 20 % w/v) incorporating Eumelanin from Black Soldier Flies (BSF-Eumel, 0.5 1.0 mg/mL), pigment endowed marked antioxidant were developed. GelMA-based fabricated an easily handled scalable cryogelation followed ultraviolet (UV) photo-crosslinking. BSF-Eumel sub-micrometer particles embedded into passive permeation solution within polymeric network. addition resulted more hydrophilic porous exhibiting good stability prolonged release 14 days. Furthermore, GelMA/BSF-Eumel exhibited activity, confirmed powerful quenching effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical (59 at mg/mL BSF-Eumel). Moreover, highest GelMA concentrations (10 accelerated human dermal fibroblasts-adult (HDF-a) migration, promoting closure 24 h. They also proved mitigate modulating production levels preventing superoxide dismutase (SOD) activity inhibition HDFs stimulated lipopolysaccharide (LPS), owing BSF-Eumel. Such remarkable outcomes make platform healing.
Язык: Английский
Процитировано
0
Polysaccharides, Год журнала: 2025, Номер 6(1), С. 13 - 13
Опубликована: Фев. 14, 2025
This study presents the synthesis of allyl-functionalized polysaccharide carbamates (AFCs) with tailored water solubility designed for use in responsive hydrogels and 3D printing applications. A modular one-pot approach was employed to produce cellulose- xylan-based AFCs, utilizing phenyl carbonates as activated compounds. By fine-tuning degree substitution (DS) functional groups, shear-thinning properties AFCs were controlled enhance gelation printability. AFC-based could be obtained by rapid induced without harmful catalysts through UV irradiation at 365 nm. The materials displayed highly porous interconnected microstructures, well mechanical resilience high swelling ratios. hydrogel formation characterized, its crosslinking calculated using HR-MAS NMR. demonstrated that behavior sensitive pH value, optimal results under neutral or acidic conditions. Initial trials confirmed material’s shaping capabilities, which is beneficial biomedical applications advanced manufacturing stimuli-responsive materials.
Язык: Английский
Процитировано
0
Journal of Bioactive and Compatible Polymers, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Cryogels are supermacroporous materials synthesized under subzero conditions, characterized by interconnected pores that provide exceptional biocompatibility, mechanical stability, and responsiveness to environmental stimuli. This review highlights their innovative applications in controlled drug delivery tissue engineering. Advances pH-sensitive stimuli-responsive cryogels have enabled precise, sustained release, enhancing therapeutic efficacy while minimizing adverse effects. In the field of engineering, serve as biomimetic scaffolds promote cell adhesion regeneration, making them valuable bone soft repair. Despite these promising developments, challenges such fragility scalability persist. discusses strategies overcome limitations, including advanced synthesis techniques, functionalization approaches, predictive design tools leveraging machine learning. These efforts emphasize transformative potential medicine, biotechnology, sustainability.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Abstract Breast cancer often develops drug resistance during chemotherapy, and immunotherapeutic agents always exhibit ineffectiveness when used as a single treatment; thus, it is necessary to develop chemo‐immunotherapy strategy in clinics. However, there still challenge evaluate the efficacy by conventional 2D cell culture animal models. In this study, we developed facile automated multiple‐well platform for fabricating tumor associated macrophages (TAMs)‐immunized breast organoids alginate hydrogels. An robotic microinjection system was building hydrogels situ seeding mixed suspensions of cells TAMs into form organoids. The induced epirubicin observed with TAMs, but could be inhibited targeted immunotherapy PLX3397. synergistic effects were also evaluated several co‐administration strategies PLX3397 combination epirubicin. RNA‐seq quantitative polymerase chain reaction further examine gene transcription levels find out three genes (IL6, CD37, GLS2) significant differences, which involved necrosis factor signaling, PI3K‐Akt signaling epidermal growth receptor tyrosine kinase inhibitor pathway. results demonstrated that showed potential replace bulk method evaluating therapeutic chem‐immunotherapy.
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2025, Номер 17(7), С. 975 - 975
Опубликована: Апрель 3, 2025
Traumatic or degenerative defects of articular cartilage impair joint function, and the treatment damage remains a challenge. By mimicking extracellular matrix (ECM), exosome-seeded cryogels may enhance cell proliferation chondral repair. ECM-based were cryopolymerized with gelatin, chondroitin sulfate, various concentrations (0%, 0.3%, 0.5%, 1%) hyaluronic acid (HA), their water content, swelling ratio, porosity, mechanical properties, effects on viability evaluated. The regenerative bone marrow-derived mesenchymal stem (BM-MSC)-derived exosome (at concentration 106 particles/mL)-seeded 0.3% HA assessed in vitro surgically induced male New Zealand rabbit vivo. porosity significantly (p < 0.05) increased Young's modulus values decreased increasing concentrations. MTT assays revealed that developed biomaterials had no cytotoxic effects. optimal cryogel composition was HA, resulting favorable properties suitable strength. Exosomes alone promoted chondrocyte (with optical densities 58% 51% greater than control). facilitated ECM deposition sulfated glycosaminoglycan synthesis. Although we observed repair via Alcian blue staining both cryogel, layered arrangement chondrocytes superior to control when used. This study potential value using BM-MSC-derived for tissue engineering treat injury.
Язык: Английский
Процитировано
0