Green waves in medicinal chemistry: ultrasound driven multicomponent reactions for sustainable synthesis of biologically active molecules
Phosphorus, sulfur, and silicon and the related elements,
Год журнала:
2024,
Номер
unknown, С. 1 - 22
Опубликована: Ноя. 27, 2024
In
recent
years,
the
study
of
chemical
synthesis
has
seen
a
transformation,
with
an
emphasis
on
increasing
efficiency
and
introducing
novel
approaches.
This
article
ventures
into
field
ultrasound-assisted
multicomponent
reactions
(MCRs),
presenting
them
as
unique
method
for
synthesizing
chemicals
physiological
applications.
Ultrasound
technology
is
employed
in
these
to
accelerate
reaction
kinetics,
increase
overall
efficiency,
create
molecular
assembly
paths.
The
covers
wide
range
applications,
from
drug
discovery
material
science,
emphasizes
pioneering
significance
MCRs
quest
bioactive
compounds.
highlights
synergistic
relationship
between
ultrasound
chemistry
by
reviewing
major
research
methodology,
well
providing
insights
their
practical
applications
fundamental
principles.
review
also
underlines
lowering
solvent
consumption
waste
creation.
As
evolves,
this
stimulates
additional
MCRs,
resulting
new
era
creativity
development
therapeutically
useful
molecules.
Язык: Английский
Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 3151 - 3173
Опубликована: Дек. 3, 2024
The
ongoing
quest
to
discover
effective
treatments
for
diseases
remains
a
significant
challenge
the
scientific
community.
Multicomponent
reactions
(MCRs)
have
emerged
as
powerful
tools
in
accelerating
drug
discovery,
enabling
rapid
generation
of
chemical
libraries
with
high
diversity
time-efficient
and
environmentally
sustainable
manner.
In
this
review,
we
focus
on
central
nervous
system
(CNS)
disorders,
particularly
Alzheimer's
disease,
Parkinson's
schizophrenia,
depression,
epilepsy,
where
MCRs
contributed
development
promising
ligands
recent
years.
Rather
than
providing
an
exhaustive
overview,
review
aims
highlight
key
studies
that
address
major
CNS
pathologies,
relevant
targets,
various
MCR
approaches.
We
carefully
selected
representative
articles
apologize
authors
whose
important
contributions
may
not
be
included.
By
concentrating
these
pivotal
studies,
strive
offer
clear
concise
perspective
current
research
trends
breakthroughs
field.
Язык: Английский