Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies DOI Creative Commons
Lucía Campos-Prieto, Aitor García-Rey, Eddy Sotelo

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 3151 - 3173

Published: Dec. 3, 2024

The ongoing quest to discover effective treatments for diseases remains a significant challenge the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling rapid generation of chemical libraries with high diversity time-efficient and environmentally sustainable manner. In this review, we focus on central nervous system (CNS) disorders, particularly Alzheimer's disease, Parkinson's schizophrenia, depression, epilepsy, where MCRs contributed development promising ligands recent years. Rather than providing an exhaustive overview, review aims highlight key studies that address major CNS pathologies, relevant targets, various MCR approaches. We carefully selected representative articles apologize authors whose important contributions may not be included. By concentrating these pivotal studies, strive offer clear concise perspective current research trends breakthroughs field.

Language: Английский

Green waves in medicinal chemistry: ultrasound driven multicomponent reactions for sustainable synthesis of biologically active molecules DOI
H. Kardani, H. V. Vaghani, Prachi Patel

et al.

Phosphorus, sulfur, and silicon and the related elements, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: Nov. 27, 2024

In recent years, the study of chemical synthesis has seen a transformation, with an emphasis on increasing efficiency and introducing novel approaches. This article ventures into field ultrasound-assisted multicomponent reactions (MCRs), presenting them as unique method for synthesizing chemicals physiological applications. Ultrasound technology is employed in these to accelerate reaction kinetics, increase overall efficiency, create molecular assembly paths. The covers wide range applications, from drug discovery material science, emphasizes pioneering significance MCRs quest bioactive compounds. highlights synergistic relationship between ultrasound chemistry by reviewing major research methodology, well providing insights their practical applications fundamental principles. review also underlines lowering solvent consumption waste creation. As evolves, this stimulates additional MCRs, resulting new era creativity development therapeutically useful molecules.

Language: Английский

Citations

0
Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies DOI Creative Commons
Lucía Campos-Prieto, Aitor García-Rey, Eddy Sotelo

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 3151 - 3173

Published: Dec. 3, 2024

The ongoing quest to discover effective treatments for diseases remains a significant challenge the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling rapid generation of chemical libraries with high diversity time-efficient and environmentally sustainable manner. In this review, we focus on central nervous system (CNS) disorders, particularly Alzheimer's disease, Parkinson's schizophrenia, depression, epilepsy, where MCRs contributed development promising ligands recent years. Rather than providing an exhaustive overview, review aims highlight key studies that address major CNS pathologies, relevant targets, various MCR approaches. We carefully selected representative articles apologize authors whose important contributions may not be included. By concentrating these pivotal studies, strive offer clear concise perspective current research trends breakthroughs field.

Language: Английский

Citations

0