Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown, С. 251 - 285
Опубликована: Ноя. 15, 2024
The
encapsulation
of
active
pharmaceutical
ingredients
(APIs)
in
microbeads
is
an
essential
step
drug
delivery;
however,
it
also
inherently
associated
with
the
need
to
control
particle
size
and
release
profiles.
Nevertheless,
most
conventional
methods
microencapsulation
fail
provide
consistent
results.
A
new
method
called
vibration-assisted
microbead
coating
a
novel
unified
technique
utilizing
mechanical
vibrations
enable
controlled,
uniform
on
APIs.
This
chapter
discusses
technology
performed
by
authors
through
formation
physical
activity
focuses
achieving
final
coated
surface
API,
shape,
size,
loading
vibration
parameters.
Additionally,
this
biocompatibility
stability
surface.
means
has
high
potential
for
delivery.
reduces
traditional
challenges
encapsulation,
if
not
eliminates
them,
more
reliable.
Based
abovementioned
findings,
propose
following
main
areas
their
further
work:
optimisation
parameters
various
APIs,
research
into
long-term
loading–release
profile,
possible
use
targeted
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1092 - 1092
Опубликована: Сен. 6, 2024
Curcumin,
as
the
main
active
component
of
turmeric
(Curcuma
longa),
has
been
demonstrated
with
various
bioactivities.
However,
its
potential
therapeutic
applications
are
hindered
by
challenges
such
poor
solubility
and
bioavailability,
rapid
metabolism,
pan-assay
interference
properties.
Recent
advancements
have
aimed
to
overcome
these
limitations
developing
novel
curcumin
analogues
modifications.
This
brief
review
critically
assesses
recent
studies
on
synthesising
different
analogues,
including
metal
complexes,
nano
particulates,
other
derivatives,
focused
antioxidant,
anti-inflammatory,
anticancer
effects
modified
analogues.
Exploring
innovative
derivatives
offers
promising
strategies
address
associated
bioavailability
efficacy
valuable
insights
for
future
research
directions.
ABSTRACT
Due
to
their
biocompatibility,
biodegradability,
and
controlled
release,
carbohydrates
polymers
are
crucial
targeted
drug
delivery
systems,
notably
for
colon
cancer
treatment.
This
article
examines
how
carbohydrate
like
chitosan,
pectin,
guar
gum,
alginate,
hyaluronic
acid,
dextran,
chondroitin
sulfate
used
in
improved
delivery.
Modifying
these
improves
loading,
stability,
release
patterns,
enhancing
chemotherapeutic
drugs'
therapeutic
index.
Chitosan
nanoparticles
pH‐responsive,
making
them
perfect
Pectin's
resistance
gastric
enzymes
colonic
bacteria
makes
it
a
promising
colon‐specific
medication
agent.
The
combination
of
with
nanotechnology,
3D
printing,
AI
allows
the
creation
stimuli‐responsive
systems
that
drugs
precisely
response
environmental
signals
pH,
redox
potential,
or
enzymatic
activity.
review
highlights
intelligent
system
design
advances
reduce
systemic
toxicity,
improve
treatment
efficacy,
patient
adherence.
Carbohydrate
will
revolutionize
personalized
accurate
alternatives.
Curcumin,
as
the
main
active
component
of
Turmeric
(Curcuma
Longa),
has
been
demonstrated
with
various
bioactivities.
However,
its
potential
therapeutic
applications
are
hindered
by
challenges
such
poor
solubility
and
bioavailability,
rapid
metabolism,
pan-assay
interference
properties.
Recent
advancements
have
aimed
to
overcome
these
limitations
developing
novel
curcumin
analogues
modifications.
This
brief
review
critically
assesses
recent
studies
on
synthesising
different
analogues,
including
metal
complexes,
nano
particulates,
other
derivatives,
focused
antioxidant,
anti-inflammatory,
anticancer
effects
modified
analogues.
Exploring
innovative
derivatives
offers
promising
strategies
address
associated
bioavailability
efficacy
valuable
insights
for
future
research
directions.
Molecules,
Год журнала:
2024,
Номер
29(16), С. 3784 - 3784
Опубликована: Авг. 9, 2024
Cancer
is
a
complex
disease
that
affects
millions
of
people
and
remains
major
public
health
problem
worldwide.
Conventional
cancer
treatments,
including
surgery,
chemotherapy,
immunotherapy,
radiotherapy,
have
limited
achievements
multiple
drawbacks,
among
which
are
healthy
tissue
damage
multidrug-resistant
phenotype
onset.
Increasing
evidence
shows
many
plants’
natural
products,
as
well
their
bioactive
compounds,
promising
anticancer
activity
exhibit
minimal
toxicity
compared
to
conventional
drugs.
However,
widespread
use
in
therapy
severely
restricted
by
limitations
terms
water
solubility,
absorption,
lack
stability,
bioavailability,
selective
targeting.
The
nanoformulations
for
product
transportation
delivery
could
be
helpful
overcoming
these
limitations,
thus
enhancing
therapeutic
efficacy
providing
the
basis
improved
treatment
strategies.
present
review
aimed
at
an
update
on
some
phytocompounds
(curcumin,
resveratrol,
quercetin,
cannabinoids,
others)
main
showing
antitumor
activities,
both
vitro
vivo,
against
such
different
human
types
breast
colorectal
cancer,
lymphomas,
malignant
melanoma,
glioblastoma
multiforme,
osteosarcoma.
intracellular
pathways
underlying
phytocompound
advantages
nanoformulation
employment
also
examined.
Finally,
this
critically
analyzes
research
gaps
causing
success
phytocompounds’
nanoformulations’
clinical
translation.
Data in Brief,
Год журнала:
2024,
Номер
53, С. 110202 - 110202
Опубликована: Фев. 20, 2024
5-Fluorouracil
(5-FU)
has
been
the
primary
drug
used
in
chemotherapy
for
colorectal
carcinoma,
and
localizing
would
be
effective
avoiding
its
side
effects
improving
therapeutic
outcomes.
One
approach
to
achieve
this
is
by
encapsulating
microbeads.
Alginate
microbeads,
particular,
exhibit
promising
pH-sensitive
properties,
making
them
an
attractive
option
colon
targeting.
Thus,
main
aim
of
study
formulate
characterize
5-FU-encapsulated
alginate
microbeads
as
a
delivery
system
controlled
release
gastrointestinal
tract.
In
study,
5-FU
was
manufactured
using
electrospray
methods.
This
method
offers
advantages
promoting
formulation
uniformly
small-sized
with
improved
performance
terms
swelling
diffusion
rates.
The
size
shape
are
394.23
±
3.077
µm
have
spherical
factor
0.026
0.022,
respectively,
which
considered
acceptable
indicative
shape.
microbeads'
encapsulation
efficiency
found
69.65
0.18%,
high
comparison
other
literature.
attenuated
total
reflectance
-
Fourier
transform
infrared
spectroscopy
(ATR-FTIR)
data
confirmed
complexation
sodium
calcium
ions,
along
matrix.
displayed
pH-dependent
swelling,
exhibiting
less
simulated
gastric
fluid
(SGF)
than
intestinal
(SIF).
Additionally,
from
pH-dependent,
cumulative
percentage
being
higher
SGF.
indicate
that
can
utilized
colon-targeted
therapy,
potentially
leading
tumor
treatment.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Cubosomes,
a
novel
class
of
nanoparticles,
have
gained
substantial
interest
in
the
field
drug
delivery
because
their
distinctive
bicontinuous
cubic
structure.
Cubosomes
are
made
up
amphiphilic
lipid
and
stabilizers
provide
robust
adaptable
platform
for
enclosing
variety
drugs.
Because
natural
high
surface
area
capacity
to
encapsulate
both
hydrophilic
hydrophobic
materials,
cubosomes
incredibly
effective
applications.
Their
potential
therapeutic
applications
is
further
enhanced
by
biocompatibility
sustained
release.
intriguing
system
oral,
ocular,
dermatological,
intravenous
Alginate-based
represent
significant
advancement
targeted
systems.
pH-responsive
nontoxic
nature,
combined
with
ability
control
release
encapsulated
drugs,
makes
them
versatile
colon-targeted
multidrug
delivery.
Researchers
focused
views
on
diagnostic
aspect
cubosomes.
volume
minimal
allow
encapsulation
imaging
agent
combination.
In
diagnosis,
loaded
real-time
tracking
medication
distribution
therapy
response.
The
integration
heralds
new
era
nanomedicine.
