Green Synthesis of Zinc Oxide Nanoparticles Using Acmella caulirhiza Leaf Extract: Characterization and Assessment of Antibacterial, Antioxidant, Anti-inflammatory and Hemolytic Properties

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Язык: Английский

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Effects of gestational diabetes mellitus and diabetes mellitus on lipid profile, antioxidants, hormones and electrolytes status in a population of Nigerian women

Опубликована: Янв. 21, 2025

Abstract Aim Gestational diabetes mellitus (GDM) cases are rising globally. This research examined the effects of GDM and whose hallmark is hyperglycemia on hormones, lipid profiles, electrolytes antioxidants in freshly diagnosed women attending teaching hospitals Ekiti State, Nigeria. Methods The cross-sectional design followed convenience sampling four groups ( n = 50): gestational (GDM), normal pregnant (NP), nonpregnant (DM) nondiabetes (ND-NP). Blood samples were collected from fasting subjects through antecubital fossa. BMI, FPG, TC, TG, LDL-C, HDL-C, sodium, potassium bicarbonate ions, MDA investigated using standard procedures spectrophotometer. Results analysed one-way ANOVA p < 0.05 was used as significant difference. There 0.05) increase FPG DM (> 5.56 mmol/l) compared to NP ND-NP subjects. HDL-C LDL-C elevated groups. Sodium ion concentration significantly ˂0.05) group relative levels ND-NP. Superoxide dismutase activity greater than NP. Progesterone level other FSH lower groups, prolactin Conclusion study suggested that could result hormonal electrolyte imbalances, reduced antioxidant levels.

Язык: Английский

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Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications

Gels, Год журнала: 2025, Номер 11(2), С. 126 - 126

Опубликована: Фев. 9, 2025

Peripheral nerve injuries pose a significant clinical challenge due to the complex biological processes involved in repair and their limited regenerative capacity. Despite advances surgical techniques, conventional treatments, such as autografts, are faced with limitations like donor site morbidity inconsistent functional outcomes. As such, there is growing interest new, novel, innovative strategies enhance regeneration. Tissue engineering/regenerative medicine its use of biomaterials an emerging example strategy. Within realm tissue engineering, functionalized hydrogels have gained considerable attention ability mimic extracellular matrix, support cell growth differentiation, even deliver bioactive molecules that can promote repair. These be engineered incorporate factors, peptides, stem cells, creating conducive microenvironment for cellular axonal Recent advancements materials well biology led development sophisticated hydrogel systems, not only provide structural support, but also actively modulate inflammation, recruitment, stimulate neurogenesis. This review explores potential peripheral repair, highlighting composition, biofunctionalization, mechanisms action. A comprehensive analysis preclinical studies provides insights into efficacy these promoting growth, neuronal survival, regeneration, and, ultimately, recovery. Thus, this aims illuminate promise transformative tool field bridging gap between complexity feasibility.

Язык: Английский

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Advances in Mussel Adhesion Proteins and Mussel-Inspired Material Electrospun Nanofibers for Their Application in Wound Repair

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Mussel refers to a marine organism with strong adhesive properties, and it secretes mussel adhesion protein (MAP). The most vital feature of MAP is the abundance 3,4-dihydroxyphenylalanine (DOPA) group lysine, which have antimicrobial, anti-inflammatory, antioxidant, cell adhesion-promoting properties can accelerate wound healing. Polydopamine (PDA) currently widely used mussel-inspired material characterized by good adhesion, biocompatibility, biodegradability. It mediate various interactions form functional coatings on cell-material surfaces. Nanofibers based materials been exerting role in repair, while there no comprehensive review presenting them. This Review introduces structure MAPs their mechanisms materials. Second, functionalized modification inspired electrospun nanofibers application repair. Finally, future development direction coping strategies are discussed. Moreover, this offer novel for repair bring about new breakthroughs innovations tissue engineering regenerative medicine.

Язык: Английский

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Regenerative medicine: Hydrogels and mesoporous silica nanoparticles

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101342 - 101342

Опубликована: Ноя. 14, 2024

Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility biodegradability, closely resemble living tissues. The versatility hydrogels has fuelled application in various fields, agriculture, biomaterials, the food industry, drug delivery, tissue engineering, regenerative medicine. combination nanoparticles, specifically Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to next level, since MSNs could improve hydrogel mechanical ability encapsulate controlled release great amounts different therapeutic agents, responsiveness a variety external internal stimuli. In this review, main features both introduced, followed by discussion hydrogels-MSNs structures an overview use applications, delivery technologies engineering.

Язык: Английский

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Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps

Gels, Год журнала: 2025, Номер 11(1), С. 52 - 52

Опубликована: Янв. 9, 2025

Carpal Tunnel Syndrome (CTS) is a prevalent neuropathic disorder caused by chronic compression of the median nerve, leading to sensory and motor impairments. Conventional treatments, such as corticosteroid injections, wrist splinting, surgical decompression, often fail provide adequate outcomes for or recurrent cases, emphasizing need innovative therapies. Hydrogels, highly biocompatible three-dimensional biomaterials with customizable properties, hold significant potential CTS management. Their ability mimic extracellular matrix facilitates localized drug delivery, anti-adhesion barrier formation, tissue regeneration. Advances in hydrogel engineering have introduced stimuli-responsive systems tailored biomechanical environment carpal tunnel, enabling sustained therapeutic release improved integration. Despite these promising developments, applications remain underexplored. Key challenges include absence CTS-specific preclinical models rigorous clinical validation. Addressing gaps could unlock full hydrogel-based interventions, which offer minimally invasive, solutions that improve long-term reduce recurrence rates. This review highlights hydrogels transformative approach therapy, advocating continued research address translational barriers. These innovations redefine treatment landscape, significantly enhancing patient care quality life.

Язык: Английский

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Enhancing burn wound care with pre-crosslinked 3D-printed patches: Bromelain delivery and aloe vera bioactives integration for improved healing outcomes

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125304 - 125304

Опубликована: Фев. 1, 2025

Burn wounds remain a major clinical challenge due to the limitations of traditional dressings, which often fail address diverse needs patients and varying wound types. This study aimed advance burn care by developing 3D-printed patch incorporating natural bioactive compounds from bromelain aloe vera. The was formulated using pre-crosslinked chitosan alginate hydrogels ensure suitability for 3D printing subsequent use. Rheological analysis revealed weak gel behaviour shear-thinning properties, ensuring excellent printability. patches exhibited outstanding swelling controlled degradation (30 %), alongside notable antioxidant anti-inflammatory potential, with polyphenolic content 1.43 ± 0.07 mg CAE/g effective scavenging DPPH, ABTS, NO radicals, IC50 values 29.51 0.30, 10.31 0.28, 5.94 0.42 mg/mL, respectively. Bioactive were consistently released across various pH levels, supporting their therapeutic efficacy. Cell viability studies confirmed strong support cell growth, while in vitro scratch tests demonstrated biocompatibility promotion closure. Histological ex vivo models cellular necrosis protein denaturation characteristic wounds. Application significantly improved epidermal morphology enhanced proliferation markers such as Ki67 α-SMA, indicative accelerated healing. While further validation is needed, these findings underscore potential an innovative solution care, offering delivery healing outcomes compared conventional dressings.

Язык: Английский

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Network Pharmacology, Molecular Docking and Experimental Validation on Potential Application of Diabetic Wound Healing of Cinnamomum zeylanicum Through Matrix Metalloproteinases-8 And 9 (MMP-8 And MMP-9)

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 1753 - 1782

Опубликована: Март 1, 2025

Background: Diabetic wounds are a significant clinical challenge due to impaired healing processes often exacerbated by elevated matrix metalloproteinases (MMPs). Cinnamomum zeylanicum , known for its anti-inflammatory and antioxidant properties, has shown potential in promoting wound healing. This study investigates the molecular docking experimental validation of 's effects on diabetic healing, focusing interaction with metalloproteinases-8 (MMP-8) 9 (MMP-9). Methods: Molecular studies were performed predict binding affinity compounds MMP-8 MMP-9. was evaluated using vivo models where induced treated extract. Various parameters measured, including contraction, hydroxyproline content, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) levels. Biochemical analyses included glucose levels, fasting blood (FBG), oral tolerance test (OGTT), histomorphological examination skin tissues. Results: results indicated high zeylanicum's bioactive MMP-9, suggesting inhibition. Experimental showed improvement contraction increased indicating enhanced collagen synthesis. Antioxidant enzyme activities (SOD, GPx, CAT) significantly elevated, while MDA levels reduced, reflecting decreased oxidative stress. analysis demonstrated improved homeostasis reduced FBG OGTT responses. Histomorphological revealed tissue architecture re-epithelialization wounds. Conclusion: exhibits promising modulating MMP-9 activities, enhancing defenses, improving regulation. These findings support therapeutic application wounds, providing foundation further investigations. Keywords: xanthosine, methylquinoline, metalloproteinase,

Язык: Английский

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Multi-modal wound classification using wound image and location by Swin Transformer and Transformer

Expert Systems with Applications, Год журнала: 2025, Номер unknown, С. 127077 - 127077

Опубликована: Март 1, 2025

Язык: Английский

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Tuning Antioxidant Function through Dynamic Design of Chitosan-Based Hydrogels

Gels, Год журнала: 2024, Номер 10(10), С. 655 - 655

Опубликована: Окт. 13, 2024

Dynamic chitosan-based hydrogels with enhanced antioxidant activity were synthesized through the formation of reversible imine linkages 5-methoxy-salicylaldehyde. These exhibited a porous structure and swelling capacity, influenced by crosslinking degree, as confirmed SEM POM analysis. The dynamic nature bonds was characterized NMR, studies in various media, aldehyde release measurements. demonstrated significantly improved compared to unmodified chitosan, evaluated DPPH method. This research highlights potential developing pH-responsive for wide range biomedical applications.

Язык: Английский

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