Fabrication of porous nano silica materials by template-assisted strategy for controlled drug delivery studies DOI
Suman Chirra, Sripal Reddy Gujjula,

Sathish Manda

и другие.

Journal of Porous Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Язык: Английский

Enhanced siRNA Delivery with Novel Smart Chitosan-Based Formulations DOI Creative Commons

Srujan Kundapura,

Dominic Craske,

Helen Tredway Graham

и другие.

Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
In vivo toxicity of chitosan-based nanoparticles: a systematic review DOI Creative Commons

Shela Salsabila,

Miski Aghnia Khairinisa, Nasrul Wathoni

и другие.

Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2025, Номер 53(1), С. 1 - 15

Опубликована: Фев. 9, 2025

Chitosan nanoparticles have been extensively utilised as polymeric drug carriers in formulations due to their potential enhance delivery, efficacy, and safety. Numerous toxicity studies previously conducted assess the safety profile of chitosan-based nanoparticles. These employed various methodologies, including test animals, interventions, different routes administration. This review aims summarise research on with a focus general tests determine LD50 NOAEL values. It can serve repository reference for nanoparticles, facilitating future further development drugs delivery system using chitosan Publications from 2014 2024 were obtained PubMed, Scopus, Google Scholar, ScienceDirect, accordance inclusion exclusion criteria.The ARRIVE 2.0 guidelines evaluate quality risk-of-bias vivo studies. The results demonstrated favourable profiles, often exhibiting reduced compared free or substances. Acute consistently reported high values, frequently exceeding 5000 mg/kg body weight, while subacute typically revealed no significant adverse effects. Various administration varied, oral, intravenous, intraperitoneal, inhalation, topical, each demonstrating promising profiles.

Язык: Английский

Процитировано

0
Use of Chitosan-Coated Conductive Copper/Nanoparticle Polymer in Drug Delivery System by Encapsulation Method DOI
Dilek Şenol, Aysel Aydın Kocaeren, Neslihan Demir

и другие.

Polymer Science Series B, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

0
Electrospun Fiber Mats with Metronidazole: Design, Evaluation, and Release Kinetics DOI Creative Commons
O. Adamczyk, Aleksandra Deptuch, Tomasz Roman Tarnawski

и другие.

The Journal of Physical Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Novel drug delivery systems (DDSs) strive to eliminate or at least reduce the side effects and limitations associated with conventional medical products. Among many potential candidates for DDSs, there are one-dimensional micro- nanostructured materials such as electrospun fibers. In this study, two different polymers, i.e., amphiphilic block copolymer (poly(2-vinylpyridine-co-styrene)) hydrophobic polymer (polycaprolactone), were utilized base Through electrospinning coaxial techniques, fibers diverse architectures obtained, homogeneous core/shell structures. An antibacterial (metronidazole) in varying concentrations was incorporated into The application of obtained fiber mats is a dressing wounds treatment periodontitis. average diameter fell within range 700-1300 nm, content 7-27 wt %. amorphization decrease crystallinity metronidazole present achieved during process. vitro release tests showed that burst can be successfully suppressed, more sustained accomplished some formulations. Therefore, promising local active substances.

Язык: Английский

Процитировано

0
Fabrication of porous nano silica materials by template-assisted strategy for controlled drug delivery studies DOI
Suman Chirra, Sripal Reddy Gujjula,

Sathish Manda

и другие.

Journal of Porous Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Язык: Английский

Процитировано

0