Polymers, Год журнала: 2024, Номер 16(2), С. 249 - 249
Опубликована: Янв. 15, 2024
Polymeric nanoparticles (NPs), utilized extensively in biomedical applications, have received increasing interest the preceding years and today represent an established part of nanotechnology field [...].
Язык: Английский
Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1796 - 1796
Опубликована: Июнь 23, 2023
Triple negative breast cancer (TNBC) has a expression of estrogen receptors (ER), progesterone (PR), and human epidermal growth factor (HER2). The survival rate for TNBC is generally worse than other subtypes. treatment made significant advances, but certain limitations remain. Treatment can be challenging since the disease various molecular A variety options are available, such as chemotherapy, immunotherapy, radiotherapy, surgery. Chemotherapy most common these options. treated with systemic chemotherapy using drugs anthracyclines taxanes in neoadjuvant or adjuvant settings. Developing resistance to anticancer off-target toxicity primary hindrances chemotherapeutic solutions cancer. It imperative that researchers, clinicians, pharmaceutical companies work together develop effective TNBC. Several studies have suggested nanotechnology potential solution problem suboptimal treatment. In this review, we summarized possible TNBC, including targeted therapy, combination nanoparticle-based some future. Moreover, gave general information about terms its characteristics aggressiveness.
Язык: Английский
Процитировано
150
RSC Advances, Год журнала: 2023, Номер 13(13), С. 8606 - 8629
Опубликована: Янв. 1, 2023
Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.
Язык: Английский
Процитировано
111
Nature Materials, Год журнала: 2023, Номер 22(10), С. 1261 - 1272
Опубликована: Авг. 17, 2023
Язык: Английский
Процитировано
91
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 1469 - 1495
Опубликована: Май 1, 2024
This manuscript offers a comprehensive overview of nanotechnology's impact on the solubility and bioavailability poorly soluble drugs, with focus BCS Class II IV drugs. We explore various nanoscale drug delivery systems (NDDSs), including lipid-based, polymer-based, nanoemulsions, nanogels, inorganic carriers. These offer improved efficacy, targeting, reduced side effects. Emphasizing crucial role nanoparticle size surface modifications, review discusses advancements in NDDSs for enhanced therapeutic outcomes. Challenges such as production cost safety are acknowledged, yet potential transforming methods is highlighted. contribution underscores importance nanotechnology pharmaceutical engineering, suggesting it significant advancement medical applications patient care.
Язык: Английский
Процитировано
64
Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1332 - 1332
Опубликована: Окт. 16, 2024
The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.
Язык: Английский
Процитировано
24
Pathology - Research and Practice, Год журнала: 2024, Номер 254, С. 155136 - 155136
Опубликована: Янв. 15, 2024
Язык: Английский
Процитировано
19
European journal of medical research, Год журнала: 2025, Номер 30(1)
Опубликована: Фев. 4, 2025
Abstract Brain tumor treatment remains a significant challenge due to their high mortality and resistance current therapies. This paper discusses the promising potential of hydrogel-based nanoparticles as innovative drug delivery systems for brain therapy. Extensive characterization techniques reveal ability these Nano-systems demonstrate prolonged blood circulation targeted delivery, leading improved survival rates. Designed with optimized physicochemical characteristics, effectively cross blood–brain barrier, circumventing major impediment brain. By delivering drugs directly bed, enhance therapeutic outcomes minimize adverse effects. In addition, this review investigates characterizing, visualizing, modifying nanoparticles, well standing challenges research avenues clinical application. Further investigations are encouraged by investigate advancements in nanoparticle approaches tumors. includes investigating tailored hydrogels, hybrid systems, computational modeling, integration gene therapy immunotherapy techniques. The study also addresses need enhanced synthesis techniques, stability, scalability, cost-cutting measures overcome obstacles advance use treating Graphical abstract
Язык: Английский
Процитировано
10
Medical Oncology, Год журнала: 2025, Номер 42(2)
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
4
Applied Sciences, Год журнала: 2022, Номер 12(19), С. 9479 - 9479
Опубликована: Сен. 21, 2022
The increase in cancer cases is undoubtedly affecting the development of new therapeutic approaches. Polymeric nanoparticles are great interest. Due to their relatively small size, possibility incorporating into them medicinal substances and ease with which physicochemical properties may be manipulated, they being used as anticancer drug delivery systems. aim this review focus on use nanoscale polymeric particles treatment colorectal cancer, breast ovarian glioblastoma multiforme, consider potential gene therapy. According several reports, polymer carriers promising solid tumors. With application, it possible precisely deliver tumor structure, overcome blood–brain barrier case brain tumors, reduce side effects agents normal cells achieve a effect lower dose. Additionally, number reports indicate that can also combination other methods treatment, mainly radiotherapy.
Язык: Английский
Процитировано
52
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 259, С. 115676 - 115676
Опубликована: Июль 23, 2023
Язык: Английский
Процитировано
44