Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(7), P. 770 - 784
Published: May 8, 2024
The
World
Health
Organization
(WHO)
reported
that
of
all
the
non-communicable
diseases,
cancer
is
considered
second
cause
death
worldwide.
This
has
driven
big
pharma
companies
to
prioritize
anticancer
products
in
their
pipeline.
In
addition,
research
focused
on
exploration
new
molecules
and
design
suitable
dosage
forms
achieve
effective
drug
delivery
tumor
site.
Nanotechnology
a
valuable
tool
build
nano
systems
with
controlled
targeted
release
properties.
Nanoparticles
can
be
fabricated
by
robust,
scalable
economic
techniques
using
various
polymers.
Moreover,
specific
functional
groups
introduced
surface
nanoparticles
enabling
targeting
tissue;
besides,
they
exhibit
versatile
patterns
according
rate
polymer
degradation.
review
outlines
processes
advances
functionalization
employed
for
treatment
breast
cancer.
therapeutic
molecules,
polymers
used
fabricate
nanoparticles,
prepare
have
been
reviewed
focus
functionalize
these
ligands
target
different
types
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1796 - 1796
Published: June 23, 2023
Triple
negative
breast
cancer
(TNBC)
has
a
expression
of
estrogen
receptors
(ER),
progesterone
(PR),
and
human
epidermal
growth
factor
(HER2).
The
survival
rate
for
TNBC
is
generally
worse
than
other
subtypes.
treatment
made
significant
advances,
but
certain
limitations
remain.
Treatment
can
be
challenging
since
the
disease
various
molecular
A
variety
options
are
available,
such
as
chemotherapy,
immunotherapy,
radiotherapy,
surgery.
Chemotherapy
most
common
these
options.
treated
with
systemic
chemotherapy
using
drugs
anthracyclines
taxanes
in
neoadjuvant
or
adjuvant
settings.
Developing
resistance
to
anticancer
off-target
toxicity
primary
hindrances
chemotherapeutic
solutions
cancer.
It
imperative
that
researchers,
clinicians,
pharmaceutical
companies
work
together
develop
effective
TNBC.
Several
studies
have
suggested
nanotechnology
potential
solution
problem
suboptimal
treatment.
In
this
review,
we
summarized
possible
TNBC,
including
targeted
therapy,
combination
nanoparticle-based
some
future.
Moreover,
gave
general
information
about
terms
its
characteristics
aggressiveness.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(13), P. 8606 - 8629
Published: Jan. 1, 2023
Cancer
is
known
as
the
most
dangerous
disease
in
world
terms
of
mortality
and
lack
effective
treatment.
Research
on
cancer
treatment
still
active
great
social
importance.
Since
1930,
chemotherapeutics
have
been
used
to
treat
cancer.
However,
such
conventional
treatments
are
associated
with
pain,
side
effects,
a
targeting.
Nanomedicines
an
emerging
alternative
due
their
targeting,
bioavailability,
low
toxicity.
Nanoparticles
target
cells
via
passive
mechanisms.
FDA
approval
for
Doxil®,
several
nano-therapeutics
developed,
few
received
use
Along
liposomes,
solid
lipid
nanoparticles,
polymeric
nanoemulsions,
even
newer
techniques
involving
extracellular
vesicles
(EVs)
thermal
nanomaterials
now
being
researched
implemented
practice.
This
review
highlights
evolution
current
status
therapy,
focus
clinical/pre-clinical
nanomedicine
studies.
Insight
also
provided
into
prospects
this
regard.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 1469 - 1495
Published: May 1, 2024
This
manuscript
offers
a
comprehensive
overview
of
nanotechnology's
impact
on
the
solubility
and
bioavailability
poorly
soluble
drugs,
with
focus
BCS
Class
II
IV
drugs.
We
explore
various
nanoscale
drug
delivery
systems
(NDDSs),
including
lipid-based,
polymer-based,
nanoemulsions,
nanogels,
inorganic
carriers.
These
offer
improved
efficacy,
targeting,
reduced
side
effects.
Emphasizing
crucial
role
nanoparticle
size
surface
modifications,
review
discusses
advancements
in
NDDSs
for
enhanced
therapeutic
outcomes.
Challenges
such
as
production
cost
safety
are
acknowledged,
yet
potential
transforming
methods
is
highlighted.
contribution
underscores
importance
nanotechnology
pharmaceutical
engineering,
suggesting
it
significant
advancement
medical
applications
patient
care.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1332 - 1332
Published: Oct. 16, 2024
The
remarkable
versatility
of
gold
nanoparticles
(AuNPs)
makes
them
innovative
agents
across
various
fields,
including
drug
delivery,
biosensing,
catalysis,
bioimaging,
and
vaccine
development.
This
paper
provides
a
detailed
review
the
important
role
AuNPs
in
delivery
therapeutics.
We
begin
by
exploring
traditional
systems
(DDS),
highlighting
revolutionizing
techniques.
then
describe
unique
intriguing
properties
that
make
exceptional
for
delivery.
Their
shapes,
functionalization,
drug-loading
bonds,
targeting
mechanisms,
release
therapeutic
effects,
cellular
uptake
methods
are
discussed,
along
with
relevant
examples
from
literature.
Lastly,
we
present
applications
medical
domains,
cancer,
cardiovascular
diseases,
ocular
diabetes,
focus
on
vitro
vivo
cancer
research.
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: Feb. 4, 2025
Abstract
Brain
tumor
treatment
remains
a
significant
challenge
due
to
their
high
mortality
and
resistance
current
therapies.
This
paper
discusses
the
promising
potential
of
hydrogel-based
nanoparticles
as
innovative
drug
delivery
systems
for
brain
therapy.
Extensive
characterization
techniques
reveal
ability
these
Nano-systems
demonstrate
prolonged
blood
circulation
targeted
delivery,
leading
improved
survival
rates.
Designed
with
optimized
physicochemical
characteristics,
effectively
cross
blood–brain
barrier,
circumventing
major
impediment
brain.
By
delivering
drugs
directly
bed,
enhance
therapeutic
outcomes
minimize
adverse
effects.
In
addition,
this
review
investigates
characterizing,
visualizing,
modifying
nanoparticles,
well
standing
challenges
research
avenues
clinical
application.
Further
investigations
are
encouraged
by
investigate
advancements
in
nanoparticle
approaches
tumors.
includes
investigating
tailored
hydrogels,
hybrid
systems,
computational
modeling,
integration
gene
therapy
immunotherapy
techniques.
The
study
also
addresses
need
enhanced
synthesis
techniques,
stability,
scalability,
cost-cutting
measures
overcome
obstacles
advance
use
treating
Graphical
abstract
Applied Sciences,
Journal Year:
2022,
Volume and Issue:
12(19), P. 9479 - 9479
Published: Sept. 21, 2022
The
increase
in
cancer
cases
is
undoubtedly
affecting
the
development
of
new
therapeutic
approaches.
Polymeric
nanoparticles
are
great
interest.
Due
to
their
relatively
small
size,
possibility
incorporating
into
them
medicinal
substances
and
ease
with
which
physicochemical
properties
may
be
manipulated,
they
being
used
as
anticancer
drug
delivery
systems.
aim
this
review
focus
on
use
nanoscale
polymeric
particles
treatment
colorectal
cancer,
breast
ovarian
glioblastoma
multiforme,
consider
potential
gene
therapy.
According
several
reports,
polymer
carriers
promising
solid
tumors.
With
application,
it
possible
precisely
deliver
tumor
structure,
overcome
blood–brain
barrier
case
brain
tumors,
reduce
side
effects
agents
normal
cells
achieve
a
effect
lower
dose.
Additionally,
number
reports
indicate
that
can
also
combination
other
methods
treatment,
mainly
radiotherapy.
