Journal of Pharmaceutical Investigation, Год журнала: 2023, Номер 53(6), С. 781 - 801
Опубликована: Окт. 30, 2023
Язык: Английский
Polymers, Год журнала: 2023, Номер 15(14), С. 3085 - 3085
Опубликована: Июль 18, 2023
Excellent wound dressings should have crucial components, including high porosity, non-toxicity, water absorption, and the ability to retain a humid environment in area facilitate healing. Unfortunately, current hamper healing process, with poor antibacterial, anti-inflammatory, antioxidant activity, frequent dressing changes, low biodegradability, mechanical properties. Hydrogels are crosslinked polymer chains three-dimensional (3D) networks that been applicable as dressings. They could on site, provide protective barrier against pathogenic infections, pain relief. Hydrogel can be obtained from natural, synthetic, or hybrid polymers. Honey is natural substance has demonstrated several therapeutic efficacies, which makes it beneficial for treatment. Honey-based hydrogel excellent characteristics, good biodegradability biocompatibility, stimulated cell proliferation reepithelization, inhibited bacterial growth, accelerated This review aimed demonstrate potential of honey-based applications complement studies accessible regarding implementing
Язык: Английский
Процитировано
20
Journal of Nanomaterials, Год журнала: 2024, Номер 2024, С. 1 - 23
Опубликована: Янв. 8, 2024
Chronic wounds, which include venous leg ulcers, diabetic foot and pressure are a global health issue that affects between 1% 2% of the developed world’s population. wound healing necessitates extensive medical intervention at costly healthcare expenses. Wound care management is mainly dependent on discovery new appropriate chronic dressing materials, it remains focus research in care. Biocompatible metallic nanoparticle-loaded offers novel opportunity for effectively overcoming inherent drawbacks traditional particularly nonhealing wounds due to their clinical complexity, example, infections, irritation, trauma, persistence foreign body or bacterial proteins, ischemia. In this review, we will primarily advancements nanoparticle-based antibacterial antioxidant materials (e.g., hydrogels, electrospun scaffolds, sponges, films) treatment overcome limitations dressings.
Язык: Английский
Процитировано
9
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 18, 2024
Abstract Hybrid structures made of natural-synthetic polymers have been interested due to high biological features combining promising physical–mechanical properties. In this research, a hybrid dressing consisting silk fibroin (SF)/polyvinyl alcohol (PVA) nanofibers and sodium alginate (SA)/gum tragacanth (GT) hydrogel incorporating cardamom extract as an antibacterial agent was prepared. Accordingly, SF extracted from cocoons followed by electrospinning in blend form with PVA (SF/PVA ratio: 1:1) under the voltage 18 kV distances 15 cm. The SEM images confirmed formation uniform, bead free fibers average diameter 199 ± 28 nm. FTIR XRD results revealed successful extraction preparation mixed fibrous mats. Next, oil extract-loaded SA/GT prepared nanofibrous structure placed on surface hydrogel. analysis depicted uniform morphology desirable matching between two layers. TGA showed desired thermal stability. swelling ratio found be 1251% after 24 h for drug released without any initial burst. MTT assay cell attachment favorable biocompatibility proliferation samples containing extract, activity values 85.35% against S. aureus 75% E. coli were obtained well. that engineered nanofibrous-hydrogel film could candidate wound healing applications skin tissue engineering.
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134694 - 134694
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
6
ACS Omega, Год журнала: 2023, Номер 9(1), С. 955 - 969
Опубликована: Дек. 19, 2023
Vaterite, a spherical polymorph of CaCO3, shows potential as carrier for the stable and controlled release silver nanoparticles (AgNPs), preventing their aggregation or loss efficacy during application. Furthermore, embedding CaCO3–Ag in poly(vinyl alcohol) (PVA) matrix helps effectively encapsulate protect microspheres provides mechanical stability better contact with wound surface. This article focuses on fabrication an antimicrobial biocompatible absorbent film embedded precipitated biogenic vaterite microspheres. The impact physical, chemical, nanomechanical, biocompatibility, properties PVA films was investigated. morphology study revealed bilayer structure inactive active surface containing homogeneously distributed CaCO3–Ag. X-ray photoelectron spectroscopy (XPS) analysis spin–orbit splitting Ag 3d5/2 3d3/2 peaks indicated presence both metallic ionic states prior to its incorporation into polymer matrix. However, upon matrix, subsequent transformation solely observed. nanomechanical improved, reduced modulus hardness increased 14.62 ± 5.23 0.64 0.29 GPa, respectively. demonstrate significant activity toward Gram-negative Escherichia coli bacteria. AgNPs studied open closed systems at pH 6, mimicking environment wound, it demonstrated dependency type capping agent used synthesis loading AgNPs. results further biocompatibility prepared human dermal fibroblast cells concentration ≤5 mg/mL, making them applicable functional dressing applications.
Язык: Английский
Процитировано
13
Gels, Год журнала: 2023, Номер 9(2), С. 113 - 113
Опубликована: Янв. 28, 2023
Physical macroporous poly(vinyl alcohol)-based cryogels formed by the freeze-thaw technique without use of any foreign cross-linkers are significant interests for biomedical applications. In present study, such gel materials loaded with antimicrobial substances were prepared and their physicochemical properties evaluated followed an assessment potential to serve as drug carriers that can be used implants treatment infected wounds. The antibiotic Ceftriaxone antimycotic Fluconazole agents. It was shown additives caused up-swelling effects respect cryogel matrix some decrease in its heat endurance but did not result a substantial change strength. With that, release from vehicle occurred diffusion restrictions, which demonstrated both spectrophotometric recording microbiological agar technique. turn, vivo biotesting drug-loaded also showed these able function rather efficient injected artificially model wounds laboratory rabbits. These results confirmed promising similar implants.
Язык: Английский
Процитировано
10
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Авг. 7, 2023
Introduction: Biopolymers, such as pullulan, a natural exopolysaccharide from Aureobasidium pullulans, and their nanocomposites are commonly used in the food, pharmaceutical, medical industries due to unique physical chemical properties. Methods: Pullulan was synthesized by A. pullulans ATCC 201253 strain. Nanocomposite films based on biosynthesized pullulan were prepared loaded with different concentrations of silver nanoparticles (AgNPs) Fusarium culmorum strain JTW1. AgNPs characterized transmission electron microscopy, Zeta potential measurements, Fourier-transform infrared spectroscopy. In turn, produced subjected physico-chemical analyses goniometry, UV shielding capacity, attenuated total reflection-Fourier-transform spectroscopy, scanning X-ray photoelectron mechanical degradation properties assessed. The antibacterial assays nanocomposite against both food-borne reference pathogens, including Listeria monocytogenes, Salmonella infantis, enterica, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, performed using standard methods. Results: small (mean 15.1 nm), spherical, displayed good stability, being coated protein biomolecules. When higher an additive films, they resulted reduced hydrophilicity light for UV-B UV-A lights. Moreover, exhibited smooth surface. Therefore, it can be concluded that addition biogenic did not change morphology texture compared control film. demonstrated remarkable activity bacteria. highest observed L. monocytogenes. Discussion: obtained results suggest novel considered use development products food packaging. this is first report pullulan-based mycogenic applications.
Язык: Английский
Процитировано
9
Gels, Год журнала: 2024, Номер 10(1), С. 39 - 39
Опубликована: Янв. 1, 2024
Gel-based membranes, a fusion of polymer networks and liquid components, have emerged as versatile tools in variety technological domains thanks to their unique structural functional attributes. Historically rooted basic filtration tasks, recent advancements synthetic strategies increased the mechanical strength, selectivity, longevity these membranes. This review summarizes evolution, emphasizing breakthroughs that positioned them at forefront cutting-edge applications. They potential for desalination pollutant removal water treatment processes, delivering efficiency often surpasses conventional counterparts. The biomedical field has embraced drug delivery tissue engineering, capitalizing on biocompatibility tunable properties. Additionally, pivotal role energy storage gel electrolytes batteries fuel cells underscores adaptability. However, despite monumental progress gel-based membrane research, challenges persist, particularly scalability long-term stability. synthesis provides an overview state-of-the-art applications membranes discusses overcome current limitations, laying foundation future innovations this dynamic field.
Язык: Английский
Процитировано
3
Polymers, Год журнала: 2024, Номер 16(5), С. 675 - 675
Опубликована: Март 1, 2024
Poly(vinyl alcohol) (PVA) physical cryogels that contained the additives of o-, m-, and p-bis-phenols or phenol were prepared, their physico-chemical characteristics macroporous morphology solute release dynamics evaluated. These phenolic caused changes in viscosity initial PVA solutions before freeze–thaw processing facilitated growth rigidity resultant cryogels, while heat endurance decreased. The magnitude effects depended on interposition hydroxyls molecules used was stipulated by H-bonding with OH-groups. Subsequent rinsing such “primary” pure water led to lowering rigidity. average size macropores inside these heterophase gels also additive type. It found substances from additive-containing occurred via virtually a free diffusion mechanism; therefore, drug delivery systems as loaded either pyrocatechol, resorcinol, hydroquinone, phenol, upon vitro agar tests, exhibited antibacterial activity typical phenols. promising biomedical potential studied nanocomposite gel materials is supposed.
Язык: Английский
Процитировано
3
Materials, Год журнала: 2025, Номер 18(2), С. 457 - 457
Опубликована: Янв. 20, 2025
Biopolymers represent a significant class of materials with potential applications in skin care due to their beneficial properties. Resveratrol is natural substance that exhibits range biological activities, including the scavenging free radicals and anti-inflammatory anti-aging effects. In this study, chitosan/konjac glucomannan resveratrol-enriched thin films were prepared. The enrichment biomaterials active ingredients common practice, as it allows desired properties be obtained final product. To characterize films, several analyses performed, infrared spectroscopy, imaging samples by SEM AFM techniques, swelling analysis pH 5.5 7.4, mechanical antioxidant assays, contact angle measurements, determination resveratrol release profile under mimicking conditions. incorporation into matrices resulted modifications chemical structure film morphology. characteristics additives found undergo deterioration. sample containing 10% exhibited higher degree than other films. resveratrol-modified demonstrated notable capacity, reduced angle, enhanced wettability. occurred rapidly initially, maximum 84% 56% released depending on type. Thus, proposed formulations have promising properties, particular good high potential, improved wettability, may serve dressings after further investigation.
Язык: Английский
Процитировано
0