Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100764 - 100764
Опубликована: Март 1, 2025
Язык: Английский
Gels, Год журнала: 2024, Номер 10(4), С. 216 - 216
Опубликована: Март 22, 2024
Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.
Язык: Английский
Процитировано
47
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141352 - 141352
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Environmental Research, Год журнала: 2024, Номер 260, С. 119567 - 119567
Опубликована: Июль 17, 2024
Язык: Английский
Процитировано
12
Phytochemistry Reviews, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 2, 2024
Язык: Английский
Процитировано
11
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(7), С. 4193 - 4230
Опубликована: Июль 3, 2024
Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either their pure form or blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various applications by incorporating unique molecular structures targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, functionalization, have been explored control mechanical electrical conductivity, hydrophilicity, degradability, rheological features, stimuli-responsiveness. For instance, custom-made known worldwide tissue engineering, drug/gene delivery, regenerative medicine. Furthermore, remarkable advancements supramolecular engineering chemistry paved way mission-oriented biomaterial synthesis fabrication of customized biomaterials. These materials can synergistically combine benefits biology tackle important questions. Herein, we categorize summarize based on methods, explore main strategies customize chemical structures. We then highlight properties using practical examples. Lastly, thoroughly describe tailor-made PSAs, along current existing challenges potential future directions.
Язык: Английский
Процитировано
10
Food Frontiers, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
Abstract Polysaccharides, also known as glycans, are biological macromolecules consisting of many monosaccharide units. Alongside proteins, nucleic acids, and lipids, they constitute the four fundamental substances crucial for life activities essential growth development living organisms. As natural products with inherent activity, polysaccharides widely available, nontoxic, possess numerous functional properties, holding immense potential advancement in food, medicine, cosmetics. Furthermore, exploration polysaccharide‐based drugs, an alternative to conventional therapies, emerges a promising avenue addressing future disease challenges. This article comprehensively reviews sources, structural characteristics, synthesis, degradation, functions, applications polysaccharides. The pharmacological applications, antitumor, antiaging, antioxidant, hypoglycemic, anti‐inflammatory, antiviral, anticoagulant is summarized. Additionally, role environmental protection discussed. It anticipated that this review will offer innovative strategic insights, serving theoretical foundation inspiration subsequent research on healthcare.
Язык: Английский
Процитировано
10
Foods, Год журнала: 2025, Номер 14(2), С. 173 - 173
Опубликована: Янв. 8, 2025
Korean yams are abundant in bioactive compounds with significant health-promoting properties. This study evaluated the anti-inflammatory potential of ethanol and water extracts from Dioscorea polystachya bulbifera RAW 264.7 macrophage cells. Among extracts, 95% extract exhibited most potent inhibition reactive oxygen species (ROS) nitric oxide (NO) production, warranting further exploration its mechanisms action. Further analysis revealed that modulated key inflammatory signaling pathways, including MAPK NF-κB, contributing to activity. Additionally, mucilage polysaccharides, a component yams, were extracted characterized for their structural functional These polysaccharides demonstrated immune-enhancing effects by reducing ROS NO production while increasing phagocytic activity Their prebiotic was also assessed through microbial growth assays, which showed an enhanced proliferation beneficial bacteria such as Lactobacillus Bifidobacterium. Furthermore, adhesion assays using Caco-2 intestinal epithelial cells these promoted probiotic inhibiting pathogenic bacteria. findings highlight emphasizing promising applications anti-inflammatory, immune-modulating, agents food nutraceutical development.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 335 - 335
Опубликована: Март 5, 2025
Background/Objectives: This study explores the bioactive potential of Bovistella utriformis biomass and its polysaccharides (PsBu) through comprehensive biochemical bioactivity analyses, focusing on their antioxidant, cytotoxic, antihyperglycemic properties. Methods: Elemental analysis determined biomass’s chemical composition. Antioxidant activity was assessed using ABTS DPPH assays. Monosaccharide composition analyzed via gas chromatography-mass spectrometry (GC-MS). In vitro cytotoxicity assays were conducted cancer normal cell lines to determine IC50 values selectivity indices (SI). Zebrafish embryo toxicity evaluated for teratogenic effects, an in vivo performed diabetic rat models. Results: The exhibited high carbon content (around 41%) nitrogen levels, with a balanced C/N ratio nearing 5. Protein exceeded 50%, alongside significant carbohydrate, fiber, ash levels. revealed inhibition rates approximately 89% (ABTS) 64% (DPPH). GC-MS identified glucose as predominant sugar (>80%), followed by galactose mannose. Additionally, HPLC detected photoprotective compound, potentially mycosporin-like amino acid. Cytotoxicity demonstrated PsBu’s selective against colon, lung, melanoma (IC50: 100–500 µg·mL−1), while effects lower (IC50 > 1300 µg·mL−1 HaCaT, >2500 HGF-1), SI approaching 27, supporting targeted anticancer agent. yielded LC50 ranging from 1.4 1.8 mg·mL−1. vivo, PsBu reduced fasting blood levels hyperglycemic rats (approximately 210 mg·dL−1 vs. 230 controls) preserved pancreatic β-cell integrity 80% 65% controls). Conclusions: These findings suggest that B. exhibit strong antioxidant activity, cells, potential, making them promising candidates further biomedical applications.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135564 - 135564
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
8
Molecular Systems Design & Engineering, Год журнала: 2024, Номер 9(10), С. 977 - 999
Опубликована: Янв. 1, 2024
Complex multilayered tissues have been regenerated by extrusion-based 3D bioprinting with biocompatible polymers. Multilayer fabrications tissue-specific bioinks are possible controlling gel properties including interaction between layers.
Язык: Английский
Процитировано
7